2868-37-3Relevant articles and documents
Mc Greer
, p. 852 (1960)
Direct quantitation of fatty acids present in bacteria and fungi: Stability of the cyclopropane ring to chlorotrimethylsilane
Eras, Jordi,Oro, Robert,Torres, Merce,Canela, Ramon
, p. 4923 - 4927 (2008)
The stability of the cyclopropane ring and the fatty acid composition of microbial cells were determined using chlorotrimethylsilane as reagent with three different conditions 80°C for 1 h, 60°C for 1 h, and 60°C for 2 h. Chlorotrimethylsilane permits a simultaneous extraction and derivatization of fatty acids. A basic method was used as reference. The bacteria, Escherichia coli, Burkholderia cepacia, and Lactobacillus brevis, and fungi Aspergillus niger and Gibberella fujikuroi were used. The stability of the cyclopropane ring on acidic conditions was tested using the cyclopropanecarboxylic acid and a commercial mixture of bacteria fatty acid methyl esters (BAME). Fisher's least significant difference test showed significant differences among the methods. The method using chlorotrimethylsilane and 1-pentanol for 1 h at 80°C gave the best results in cyclopropane, hydroxyl, and total fatty acid recoveries. This procedure allows the fast and easy one-step direct extraction derivatization.
Preparation method of cyclopropylamine intermediate cyclopropanecarboxylic acid methyl ester
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Paragraph 0020-0048, (2021/05/15)
The invention relates to a preparation method of a cyclopropylamine intermediate methyl cyclopropanecarboxylate, and solves the technical problems that an existing preparation method is unreasonable, high in requirements on reaction equipment, complicated to operate, low in yield and unsuitable for industrial production. With methyl acetate and 1,2-dihaloethane as raw materials, and under the action of potassium carbonate and a phase transfer catalyst, alkylation reaction is carried out to obtain methyl cyclopropanecarboxylate. The method can be widely applied to the technical field of synthesis of medical intermediates.
Preparation method of methyl cyclopropanecarboxylate
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Paragraph 0022-0060, (2020/08/22)
The invention relates to a preparation method of methyl cyclopropanecarboxylate. The technical problems that an existing preparation method is unreasonable, by-products are unsalable, the requirementfor air tightness of a production device is high, and the existing preparation method is not suitable for industrial production are solved. According to the method, gamma-butyrolactone is used as a starting raw material, dimethyl sulfate and gamma-butyrolactone are subjected to transesterification ring opening under the action of a catalyst potassium carbonate, and cyclization is performed under the strong alkaline condition to generate methyl cyclopropanecarboxylate. The method can be widely applied to the technical field of medical intermediate synthesis.