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2868-37-3

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2868-37-3 Usage

Chemical Properties

CLEAR COLOURLESS LIQUID

Uses

Different sources of media describe the Uses of 2868-37-3 differently. You can refer to the following data:
1. Methyl cyclopropane carboxylate is used as a reagent in the synthesis of N’thiazole and N-pyrazole based inhibitors of MAP kinase p38α.
2. It is primarily used an intermediate in the manufacture of pharmaceutical and agrochemical products. Methyl cyclopropane carboxylate is used as a reagent in the synthesis of N?-thiazole and N-pyrazole based inhibitors of MAP kinase p38α.

Synthesis Reference(s)

Tetrahedron Letters, 9, p. 4545, 1968 DOI: 10.1016/S0040-4039(01)99181-6

Check Digit Verification of cas no

The CAS Registry Mumber 2868-37-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,8,6 and 8 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 2868-37:
(6*2)+(5*8)+(4*6)+(3*8)+(2*3)+(1*7)=113
113 % 10 = 3
So 2868-37-3 is a valid CAS Registry Number.
InChI:InChI=1/C5H8O2/c1-7-5(6)4-2-3-4/h4H,2-3H2,1H3

2868-37-3 Well-known Company Product Price

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  • Alfa Aesar

  • (B20853)  Methyl cyclopropanecarboxylate, 98%   

  • 2868-37-3

  • 25g

  • 261.0CNY

  • Detail
  • Alfa Aesar

  • (B20853)  Methyl cyclopropanecarboxylate, 98%   

  • 2868-37-3

  • 100g

  • 748.0CNY

  • Detail
  • Alfa Aesar

  • (B20853)  Methyl cyclopropanecarboxylate, 98%   

  • 2868-37-3

  • 500g

  • 2806.0CNY

  • Detail

2868-37-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name Methyl cyclopropane carboxylate

1.2 Other means of identification

Product number -
Other names Methyl cyclopropylcarboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2868-37-3 SDS

2868-37-3Synthetic route

methyl 4-((methoxysulfonyl)oxy)butyrate

methyl 4-((methoxysulfonyl)oxy)butyrate

methyl cyclopropylcarboxylate
2868-37-3

methyl cyclopropylcarboxylate

Conditions
ConditionsYield
With sodium methylate In methanol at 105 - 110℃; for 3.5h; Temperature;95.83%
acetic acid methyl ester
79-20-9

acetic acid methyl ester

ethylene dibromide
106-93-4

ethylene dibromide

methyl cyclopropylcarboxylate
2868-37-3

methyl cyclopropylcarboxylate

Conditions
ConditionsYield
With potassium carbonate; 1-butyl-3-methylimidazolium Tetrafluoroborate In N,N-dimethyl-formamide at 25℃; for 6h; Temperature; Concentration;94%
acrylic acid methyl ester
292638-85-8

acrylic acid methyl ester

1,1-dibromomethane
74-95-3

1,1-dibromomethane

methyl cyclopropylcarboxylate
2868-37-3

methyl cyclopropylcarboxylate

Conditions
ConditionsYield
With sodium iodide; nickel dibromide; zinc In tetrahydrofuran at 0℃; for 24h;90%
With tetrakis(triphenylphosphine)nickel(0); zinc dibromide; zinc In tetrahydrofuran for 46h; Product distribution; Mechanism; Ambient temperature; other olefins, other catalytic systems, var. time, var. temp., var. conc., var. solvents;86%
sodium ethylene

sodium ethylene

methyl 2-chlorobutanoate
26464-32-4, 149948-70-9, 149948-80-1

methyl 2-chlorobutanoate

A

2-ethyl-1-hexyl ester

2-ethyl-1-hexyl ester

B

methyl cyclopropylcarboxylate
2868-37-3

methyl cyclopropylcarboxylate

Conditions
ConditionsYield
In methanol; water; ethylene glycolA n/a
B 82%
cyclopropanecarboxylic acid
1759-53-1

cyclopropanecarboxylic acid

methyl cyclopropylcarboxylate
2868-37-3

methyl cyclopropylcarboxylate

Conditions
ConditionsYield
70%
Methyl 4-bromobutyrate
4897-84-1

Methyl 4-bromobutyrate

propargyl alcohol
107-19-7

propargyl alcohol

methyl cyclopropylcarboxylate
2868-37-3

methyl cyclopropylcarboxylate

Conditions
ConditionsYield
With n-butyllithium; triphenylmethane In tetrahydrofuran; hexane at 0℃; for 1h;61%
Methyl 4-bromobutyrate
4897-84-1

Methyl 4-bromobutyrate

propargyl alcohol
107-19-7

propargyl alcohol

A

methyl cyclopropylcarboxylate
2868-37-3

methyl cyclopropylcarboxylate

B

cyclopropanecarboxylic acid
1759-53-1

cyclopropanecarboxylic acid

Conditions
ConditionsYield
With lithium amide In diethyl ether for 4h; Heating;A 20%
B n/a
methanol
67-56-1

methanol

cyclopropanecarboxylic acid chloride
4023-34-1

cyclopropanecarboxylic acid chloride

methyl cyclopropylcarboxylate
2868-37-3

methyl cyclopropylcarboxylate

methanol
67-56-1

methanol

cyclopropanecarboxylic acid
1759-53-1

cyclopropanecarboxylic acid

methyl cyclopropylcarboxylate
2868-37-3

methyl cyclopropylcarboxylate

Conditions
ConditionsYield
With sulfuric acid
With chloro-trimethyl-silane at 80℃; for 1h; Inert atmosphere;83.3 %Chromat.
With thionyl chloride at 80℃;
methyl 4-chlorobutyrate
3153-37-5

methyl 4-chlorobutyrate

methyl cyclopropylcarboxylate
2868-37-3

methyl cyclopropylcarboxylate

Conditions
ConditionsYield
With copper(I) oxide; Cyclohexyl isocyanide
With calcium methylate at 100℃; Temperature; Autoclave; Green chemistry;170.3 g
sodium methylate
124-41-4

sodium methylate

Cyclopropanecarboxaldehyde
1489-69-6

Cyclopropanecarboxaldehyde

methyl cyclopropylcarboxylate
2868-37-3

methyl cyclopropylcarboxylate

Conditions
ConditionsYield
In methanol
trimethyl orthocyclopropanecarboxylate
54917-76-9

trimethyl orthocyclopropanecarboxylate

A

methanol
67-56-1

methanol

B

methyl cyclopropylcarboxylate
2868-37-3

methyl cyclopropylcarboxylate

Conditions
ConditionsYield
With hydrogenchloride; water at 25.1℃; Rate constant; rate constant for the hydronium ion catalyzed hydrolysis;
With water at 25.1℃; Rate constant; rate constant for the hydrolysis maesured in buffer solutions (H2PO4-/HPO42-, Tris*H+/Tris); pH 6.5-8.2;
2-cyclopropyl-2-methoxy-5,5-dimethyl-Δ3-1,3,4-oxadiazoline
119393-21-4

2-cyclopropyl-2-methoxy-5,5-dimethyl-Δ3-1,3,4-oxadiazoline

dimethyl acetylenedicarboxylate
762-42-5

dimethyl acetylenedicarboxylate

A

methyl cyclopropylcarboxylate
2868-37-3

methyl cyclopropylcarboxylate

B

dimethyl 3,3-dimethyl-3H-pyrazole-4,5-dicarboxylate
13566-26-2

dimethyl 3,3-dimethyl-3H-pyrazole-4,5-dicarboxylate

Conditions
ConditionsYield
In benzene for 5h; Ambient temperature; Irradiation;
cyclopropylmethyl methyl ether
1003-13-0

cyclopropylmethyl methyl ether

A

methyl cyclopropylcarboxylate
2868-37-3

methyl cyclopropylcarboxylate

B

cyclopropanecarboxylic acid
1759-53-1

cyclopropanecarboxylic acid

Conditions
ConditionsYield
With ruthenium tetroxide In water; acetone at 30℃;
methyl iodide
74-88-4

methyl iodide

silver salt of/the/ cyclopropane-carboxylic acid

silver salt of/the/ cyclopropane-carboxylic acid

methyl cyclopropylcarboxylate
2868-37-3

methyl cyclopropylcarboxylate

trifluoro-methanesulfonic acid 2,2-dimethoxy-cyclobutyl ester

trifluoro-methanesulfonic acid 2,2-dimethoxy-cyclobutyl ester

methyl cyclopropylcarboxylate
2868-37-3

methyl cyclopropylcarboxylate

Conditions
ConditionsYield
With 2,6-dimethylpyridine In various solvent(s) at 25℃; Kinetics;
cyclopropanecarboxylic acid
1759-53-1

cyclopropanecarboxylic acid

methyl cyclopropylcarboxylate
2868-37-3

methyl cyclopropylcarboxylate

Conditions
ConditionsYield
With sulfuric acid In methanol
cyclopropane-1,1-dicarboxylic acid
598-10-7

cyclopropane-1,1-dicarboxylic acid

methyl cyclopropylcarboxylate
2868-37-3

methyl cyclopropylcarboxylate

Conditions
ConditionsYield
at 60℃;
Methyl 4-methoxybutyrate
29006-01-7

Methyl 4-methoxybutyrate

methyl cyclopropylcarboxylate
2868-37-3

methyl cyclopropylcarboxylate

Conditions
ConditionsYield
With sodium methylate In methanol at 100℃; for 5h; Temperature; Time;768.32 g
2-methylthio-4-methylpyrimidine
14001-63-9

2-methylthio-4-methylpyrimidine

methyl cyclopropylcarboxylate
2868-37-3

methyl cyclopropylcarboxylate

1-cyclopropyl-2-(2-methylsulfanyl-pyrimidin-4-yl)-ethanone
1256963-04-8

1-cyclopropyl-2-(2-methylsulfanyl-pyrimidin-4-yl)-ethanone

Conditions
ConditionsYield
Stage #1: 2-methylthio-4-methylpyrimidine With lithium hexamethyldisilazane In tetrahydrofuran at 0℃; for 0.0833333h;
Stage #2: methyl cyclopropylcarboxylate In tetrahydrofuran at 20℃; for 0.5h;
100%
methyl cyclopropylcarboxylate
2868-37-3

methyl cyclopropylcarboxylate

ethylmagnesium bromide
925-90-6

ethylmagnesium bromide

hydroxy-1 cyclopropyl-1 cyclopropane
54251-80-8

hydroxy-1 cyclopropyl-1 cyclopropane

Conditions
ConditionsYield
With titanium(IV) isopropylate In diethyl ether at 20℃; for 3h;99%
With titanium(IV) isopropylate In 2-methyltetrahydrofuran at 15 - 20℃; for 4h; Solvent; Temperature;91%
With titanium(IV) isopropylate In tetrahydrofuran at -10 - 20℃;55%
Cyclopropyl methyl ketone
765-43-5

Cyclopropyl methyl ketone

methyl cyclopropylcarboxylate
2868-37-3

methyl cyclopropylcarboxylate

1,3-dicyclopropyl-1,3-propanedione
30923-64-9

1,3-dicyclopropyl-1,3-propanedione

Conditions
ConditionsYield
Stage #1: Cyclopropyl methyl ketone; methyl cyclopropylcarboxylate With ethanol; sodium hydride In tetrahydrofuran at 20℃; Inert atmosphere;
Stage #2: With 18-crown-6 ether at 40℃; for 3h;
99%
With sodium methylate In dimethyl sulfoxide at 55℃; for 8h;78%
With sodium methylate In dimethyl sulfoxide at 55℃; for 8h;78%
methyl cyclopropylcarboxylate
2868-37-3

methyl cyclopropylcarboxylate

3-Bromobenzenesulfonyl chloride
2905-24-0

3-Bromobenzenesulfonyl chloride

(S)-methyl 2-(3-bromophenylsulfonamido)cyclopropionate

(S)-methyl 2-(3-bromophenylsulfonamido)cyclopropionate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 3h;97%
methyl cyclopropylcarboxylate
2868-37-3

methyl cyclopropylcarboxylate

acetonitrile
75-05-8

acetonitrile

3-cyclopropyl-3-oxo-propionitrile
118431-88-2

3-cyclopropyl-3-oxo-propionitrile

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran at 70℃; for 16h;96%
With n-butyllithium In tetrahydrofuran; hexane at -60 - 20℃;46%
With sodium hydride In 1,4-dioxane
With potassium 2-methylbutan-2-olate In tetrahydrofuran; toluene at 0 - 20℃; for 78h;
methyl cyclopropylcarboxylate
2868-37-3

methyl cyclopropylcarboxylate

methylmagnesium bromide
75-16-1

methylmagnesium bromide

2-cyclopropyl-2-propanol
930-39-2

2-cyclopropyl-2-propanol

Conditions
ConditionsYield
In tetrahydrofuran92%
methyl cyclopropylcarboxylate
2868-37-3

methyl cyclopropylcarboxylate

propyl bromide
106-94-5

propyl bromide

4-cyclopropylheptan-4-ol
57583-50-3

4-cyclopropylheptan-4-ol

Conditions
ConditionsYield
Stage #1: propyl bromide With magnesium In tetrahydrofuran for 3.5h; Reflux;
Stage #2: methyl cyclopropylcarboxylate In tetrahydrofuran at 24 - 28℃; for 8h; Temperature;
91%
Stage #1: propyl bromide With magnesium In tetrahydrofuran for 3.5h; Reflux;
Stage #2: methyl cyclopropylcarboxylate In tetrahydrofuran at 0 - 28℃; for 8h; Temperature;
91%
Stage #1: propyl bromide With magnesium In tetrahydrofuran for 3.5h; Reflux;
Stage #2: methyl cyclopropylcarboxylate In tetrahydrofuran at 0 - 28℃; for 8h; Temperature;
91%
Dimethyl ether
115-10-6

Dimethyl ether

methyl cyclopropylcarboxylate
2868-37-3

methyl cyclopropylcarboxylate

trimethyl orthocyclopropanecarboxylate
54917-76-9

trimethyl orthocyclopropanecarboxylate

Conditions
ConditionsYield
With boron trifluoride In Hexadecane at 110℃; for 12h; Autoclave;91%
methyl cyclopropylcarboxylate
2868-37-3

methyl cyclopropylcarboxylate

cyclopropylmethanol-α,α-d2
90568-07-3

cyclopropylmethanol-α,α-d2

Conditions
ConditionsYield
With lithium aluminium deuteride In diethyl ether for 10h; Heating;90%
With lithium aluminium deuteride In tetrahydrofuran at -10 - 0℃; for 1h; Inert atmosphere;76.1%
With lithium aluminium deuteride In diethyl ether
With lithium aluminium deuteride In diethyl ether for 12h; Heating;
With lithium aluminium deuteride In diethyl ether at 0 - 20℃; for 12h;
methyl cyclopropylcarboxylate
2868-37-3

methyl cyclopropylcarboxylate

acetylacetone
123-54-6

acetylacetone

2-cyclopropyl-6-methyl-pyridin-4-ol

2-cyclopropyl-6-methyl-pyridin-4-ol

Conditions
ConditionsYield
Stage #1: methyl cyclopropylcarboxylate; acetylacetone With sodium hydride In 1,2-dimethoxyethane; mineral oil at 110℃; for 4.66667h;
Stage #2: With ammonium hydroxide for 3h; Reflux;
90%
methyl cyclopropylcarboxylate
2868-37-3

methyl cyclopropylcarboxylate

4-(4,5-dihydro-1H-imidazol-2-yl)-N'-hydroxybenzimidamide

4-(4,5-dihydro-1H-imidazol-2-yl)-N'-hydroxybenzimidamide

5-cyclopropyl-3-(4-(4,5-dihydro-1H-imidazol-2-yl)phenyl)-1,2,4-oxadiazole

5-cyclopropyl-3-(4-(4,5-dihydro-1H-imidazol-2-yl)phenyl)-1,2,4-oxadiazole

Conditions
ConditionsYield
With sodium hydroxide In dimethyl sulfoxide at 20℃;89%
With sodium hydroxide In dimethyl sulfoxide at 20℃;
methyl cyclopropylcarboxylate
2868-37-3

methyl cyclopropylcarboxylate

Cyclopropylmethanol
2516-33-8

Cyclopropylmethanol

Conditions
ConditionsYield
With sodium In methanol at 45 - 65℃; for 2h; Inert atmosphere; Large scale;88%
With lithium aluminium tetrahydride In diethyl ether at 0℃; for 1h;85%
Stage #1: methyl cyclopropylcarboxylate With methanol; aluminum (III) chloride; sodium tetrahydroborate at 2℃;
Stage #2: With ammonium chloride In water Temperature; Reagent/catalyst;
74.3%
methyl cyclopropylcarboxylate
2868-37-3

methyl cyclopropylcarboxylate

acetonitrile
75-05-8

acetonitrile

3-cyclopropyl-3-ketopropionitrile sodium salt

3-cyclopropyl-3-ketopropionitrile sodium salt

Conditions
ConditionsYield
With sodium methylate at 63 - 95℃; Product distribution / selectivity;86%
With sodium methylate at 82℃; for 6h; Product distribution / selectivity; Heating / reflux;
With sodium methylate In N,N-dimethylimidazolidin-2-one at 82℃; for 6h; Product distribution / selectivity; Heating / reflux;
With sodium methylate In dimethyl sulfoxide at 82℃; for 6h; Product distribution / selectivity; Heating / reflux;
methyl cyclopropylcarboxylate
2868-37-3

methyl cyclopropylcarboxylate

acetophenone
98-86-2

acetophenone

1-cyclopropyl-3-phenyl-1,3-propanedione
30923-65-0

1-cyclopropyl-3-phenyl-1,3-propanedione

Conditions
ConditionsYield
With hydrogenchloride; sodium methylate In n-heptane; water; dimethyl sulfoxide86%
With hydrogenchloride; sodium methylate In n-heptane; water; dimethyl sulfoxide86%
methyl cyclopropylcarboxylate
2868-37-3

methyl cyclopropylcarboxylate

1-(5-bromo-2-methylphenyl)ethan-1-one
90326-54-8

1-(5-bromo-2-methylphenyl)ethan-1-one

1-(5-bromo-2-methylphenyl)-3-cyclopropylpropane-1,3-dione

1-(5-bromo-2-methylphenyl)-3-cyclopropylpropane-1,3-dione

Conditions
ConditionsYield
With sodium methylate In dimethyl sulfoxide at 50℃; for 5h;80%
methyl cyclopropylcarboxylate
2868-37-3

methyl cyclopropylcarboxylate

1-(benzotriazol-1-yl)propargyl ethyl ether
171815-69-3

1-(benzotriazol-1-yl)propargyl ethyl ether

C21H19N3O2

C21H19N3O2

Conditions
ConditionsYield
Stage #1: 1-(benzotriazol-1-yl)propargyl ethyl ether With n-butyllithium In tetrahydrofuran at -78℃;
Stage #2: methyl cyclopropylcarboxylate In tetrahydrofuran at -78℃;
80%
methyl cyclopropylcarboxylate
2868-37-3

methyl cyclopropylcarboxylate

ethylmagnesium bromide
925-90-6

ethylmagnesium bromide

cyclopropyldiethylcarbinol
4364-55-0

cyclopropyldiethylcarbinol

Conditions
ConditionsYield
75%
methyl cyclopropylcarboxylate
2868-37-3

methyl cyclopropylcarboxylate

aniline
62-53-3

aniline

N-phenylcyclopropanecarboxamide
2759-52-6

N-phenylcyclopropanecarboxamide

Conditions
ConditionsYield
With sodium t-butanolate In neat (no solvent) at 20℃; for 1h; Inert atmosphere; Schlenk technique; Green chemistry;73%
methyl cyclopropylcarboxylate
2868-37-3

methyl cyclopropylcarboxylate

p-toluamidoxime
19227-13-5

p-toluamidoxime

3-(4-methylphenyl)-5-cyclopropyl-1,2,4-oxadiazole

3-(4-methylphenyl)-5-cyclopropyl-1,2,4-oxadiazole

Conditions
ConditionsYield
With sodium hydroxide In dimethyl sulfoxide at 20℃; for 4h;72%
methanol
67-56-1

methanol

methyl cyclopropylcarboxylate
2868-37-3

methyl cyclopropylcarboxylate

methyl (2R)-2-hydroxy-3-methoxypropanoate

methyl (2R)-2-hydroxy-3-methoxypropanoate

Conditions
ConditionsYield
With Mg2(SO3CF3)2 at 40℃; for 16h;69%
1-benzyl-2-pyrrolidone
5291-77-0

1-benzyl-2-pyrrolidone

methyl cyclopropylcarboxylate
2868-37-3

methyl cyclopropylcarboxylate

1-benzyl-3-(cyclopropanecarbonyl)pyrrolidin-2-one

1-benzyl-3-(cyclopropanecarbonyl)pyrrolidin-2-one

Conditions
ConditionsYield
Stage #1: 1-benzyl-2-pyrrolidone With lithium diisopropyl amide In tetrahydrofuran; hexane at -75 - -60℃; for 1.16667h;
Stage #2: methyl cyclopropylcarboxylate In tetrahydrofuran; hexane at -75 - -60℃; for 1.33333h;
66%
methyl cyclopropylcarboxylate
2868-37-3

methyl cyclopropylcarboxylate

1,2-bicyclopropylacetylene
27998-49-8

1,2-bicyclopropylacetylene

1,2,3,4,5-pentacyclopropylcyclopentadiene

1,2,3,4,5-pentacyclopropylcyclopentadiene

Conditions
ConditionsYield
Stage #1: 1,2-bicyclopropylacetylene With isobutylmagnesium bromide; titanocene dichloride In diethyl ether at 20℃; for 0.5h;
Stage #2: With cerium(III) chloride In tetrahydrofuran; diethyl ether at 20℃; for 1h;
Stage #3: methyl cyclopropylcarboxylate In tetrahydrofuran; diethyl ether at 20℃; for 1h;
64%
vinylcaprolactam
2235-00-9

vinylcaprolactam

methyl cyclopropylcarboxylate
2868-37-3

methyl cyclopropylcarboxylate

3-cyclopropanecarbonyl-1-vinyl-azepan-2-one

3-cyclopropanecarbonyl-1-vinyl-azepan-2-one

Conditions
ConditionsYield
Stage #1: vinylcaprolactam With methanol; sodium hydride In toluene Heating;
Stage #2: methyl cyclopropylcarboxylate In toluene for 10h; Claisen condensation; Heating;
64%
methyl cyclopropylcarboxylate
2868-37-3

methyl cyclopropylcarboxylate

N-hydroxy-3-(4-methoxy-phenyl)-1-methyl-6-oxo-1,6-dihydro-[2,4']bipyridinyl-5-carboxamidine

N-hydroxy-3-(4-methoxy-phenyl)-1-methyl-6-oxo-1,6-dihydro-[2,4']bipyridinyl-5-carboxamidine

5-(5-cyclopropyl-[1,2,4]oxadiazol-3-yl)-3-(4-methoxy-phenyl)-1-methyl-1H-[2,4']bipyridinyl-6-one

5-(5-cyclopropyl-[1,2,4]oxadiazol-3-yl)-3-(4-methoxy-phenyl)-1-methyl-1H-[2,4']bipyridinyl-6-one

Conditions
ConditionsYield
Stage #1: N-hydroxy-3-(4-methoxy-phenyl)-1-methyl-6-oxo-1,6-dihydro-[2,4']bipyridinyl-5-carboxamidine With 4 A molecular sieve; sodium hydride for 0.5h;
Stage #2: methyl cyclopropylcarboxylate In N,N-dimethyl-formamide at 80℃; for 2h; Further stages.;
63%
methyl cyclopropylcarboxylate
2868-37-3

methyl cyclopropylcarboxylate

diphenylmethyllithium
881-42-5

diphenylmethyllithium

2,2-diphenyl-1-cyclopropylethan-1-one
52692-22-5

2,2-diphenyl-1-cyclopropylethan-1-one

Conditions
ConditionsYield
In tetrahydrofuran; hexane for 0.166667h; Heating;61.6%

2868-37-3Relevant articles and documents

Mc Greer

, p. 852 (1960)

Direct quantitation of fatty acids present in bacteria and fungi: Stability of the cyclopropane ring to chlorotrimethylsilane

Eras, Jordi,Oro, Robert,Torres, Merce,Canela, Ramon

, p. 4923 - 4927 (2008)

The stability of the cyclopropane ring and the fatty acid composition of microbial cells were determined using chlorotrimethylsilane as reagent with three different conditions 80°C for 1 h, 60°C for 1 h, and 60°C for 2 h. Chlorotrimethylsilane permits a simultaneous extraction and derivatization of fatty acids. A basic method was used as reference. The bacteria, Escherichia coli, Burkholderia cepacia, and Lactobacillus brevis, and fungi Aspergillus niger and Gibberella fujikuroi were used. The stability of the cyclopropane ring on acidic conditions was tested using the cyclopropanecarboxylic acid and a commercial mixture of bacteria fatty acid methyl esters (BAME). Fisher's least significant difference test showed significant differences among the methods. The method using chlorotrimethylsilane and 1-pentanol for 1 h at 80°C gave the best results in cyclopropane, hydroxyl, and total fatty acid recoveries. This procedure allows the fast and easy one-step direct extraction derivatization.

Preparation method of cyclopropylamine intermediate cyclopropanecarboxylic acid methyl ester

-

Paragraph 0020-0048, (2021/05/15)

The invention relates to a preparation method of a cyclopropylamine intermediate methyl cyclopropanecarboxylate, and solves the technical problems that an existing preparation method is unreasonable, high in requirements on reaction equipment, complicated to operate, low in yield and unsuitable for industrial production. With methyl acetate and 1,2-dihaloethane as raw materials, and under the action of potassium carbonate and a phase transfer catalyst, alkylation reaction is carried out to obtain methyl cyclopropanecarboxylate. The method can be widely applied to the technical field of synthesis of medical intermediates.

Preparation method of methyl cyclopropanecarboxylate

-

Paragraph 0022-0060, (2020/08/22)

The invention relates to a preparation method of methyl cyclopropanecarboxylate. The technical problems that an existing preparation method is unreasonable, by-products are unsalable, the requirementfor air tightness of a production device is high, and the existing preparation method is not suitable for industrial production are solved. According to the method, gamma-butyrolactone is used as a starting raw material, dimethyl sulfate and gamma-butyrolactone are subjected to transesterification ring opening under the action of a catalyst potassium carbonate, and cyclization is performed under the strong alkaline condition to generate methyl cyclopropanecarboxylate. The method can be widely applied to the technical field of medical intermediate synthesis.

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