2878-14-0

Basic information

• Product Name: 2-Methylallylamine
• Synonyms: CH2=C(CH3)CH2NH2;METHALLYLAMINE;2-METHYLALLYLAMINE;2-METHYL-2-PROPEN-1-AMINE;3-(METHYLAMINO)-1-PROPEN;AKOS 91389;2-methylprop-2-en-1-ylamine;2-methylallylamine, 98 %
• CAS NO: 2878-14-0
• Molecular Formula: C₄H₉N
• Molecular Weight: 71.12
• EINECS: 220-724-2
• Mol File: 2878-14-0.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 78 °C
• Flash Point: -28 °C
• Appearance: Clear colorless/Liquid
• Density: 0.78
• Vapor Pressure: 75.3mmHg at 25°C
• Refractive Index: 1.429-1.432
• Storage Temp.: 0-6°C
• PKA: 9.45±0.29(Predicted)
• CAS DataBase Reference: 2-Methylallylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methylallylamine(2878-14-0)
• EPA Substance Registry System: 2-Methylallylamine(2878-14-0)

Safety Data

• Hazard Codes: Xi-F,F,Xi,C,Xn
• Statements: 36/37/38-11-36-22
• Safety Statements: 37/39-26-16
• RIDADR: 1992
• WGK Germany: 3
• HazardClass: FLAMMABLE, CORROSIVE
• PackingGroup: II
• Hazardous Substances Data: 2878-14-0(Hazardous Substances Data)

Usage

Chemical Properties

clear colorless liquid

Uses

2-Methylallylamine is an intermediate used in the synthesis of urea-containing FK506 binding protein inhibitors. It is also used to prepare benzothiazepine dioxides with HIV-1 protease inhibitory activities.

InChI:InChI=1/C4H9N/c1-4(2)3-5/h1,3,5H2,2H3/p+1

Upstream product

• 2658-24-4 2,2-dimethylaziridine 
• 108-22-5 Isopropenyl acetate 
• 2854-16-2 1-Amino-2-methyl-propan-2-ol 
• 67-56-1 methanol 
• 18292-39-2 (2-methyl-1-propen-1-yl)trimethylsilane 
• 104131-54-6 2-methyl-2-propenyl azide 
• 91989-82-1 N-methallyltrichloroacetamide 
• 1203-15-2 N-(2-methyl-2-propenyl)benzenesulfonamide 
• 126-98-7 methacrylonitrile 
• 563-47-3 3-Chloro-2-methylpropene 

Downstream Products

• 709-25-1 N-(2-methylallyl)benzamide 
• 25913-68-2 N-(2-methylprop-2-en-1-yl)-N'-phenylthiourea 
• 73286-67-6 N-(2-methyl-2-propenyl)acetamide 
• 102066-10-4 2-cyclohex-2-enone 
• 91230-06-7 3--2-methylprop-1-ene 
• 934667-58-0 2-(4-chloro-phenyl)-N-isopropyl-2-[[(7-methoxy-2-oxo-2H-chromen-4-yl)-acetyl]-(2-methyl-allyl)-amino]-acetamide 
• 65755-34-2 C₁₁H₁₃N 
• 695-98-7 2,3,5-trimethyl-pyridine 
• 141883-60-5 2-cyano-N-(2-methylprop-2-enyl)benzenamine 
• 1021537-66-5 2-fluoro-6-{2-[(4aS,5R)-1-(4-fluorophenyl)-5-hydroxy-4a-methyl-1,4,4a,5,6,7-hexahydrocyclopenta[f]indazol-5-yl]ethyl}-N-(2-methylprop-2-en-1-yl)benzamide 
• 1301768-16-0 2-bromo-4-methoxy-N-(2-methylallyl)benzenesulfonamide 

Relevant articles and documents

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A facile approach to α,β-unsaturated lactams by ring-closing metathesis

[MediaObject not available: see fulltext.]A facile and efficient strategy for the synthesis of α,β-unsaturated lactams through ring-closing metathesis of easily prepared diene amides is being reported here. Reaction conditions were optimized for metathetic cyclization of diene amides to obtain five- to sevenmembered unsubstituted and β-substituted α,β-unsaturated lactams in good to excellent yield.

SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS INHIBITORS

The use of a compound of formula (I) 1 or a salt, ester or amide thereof; where X is O, or S, S(O) or S(O)2, or NR6 where R6 is hydrogen or C1-6 alkyl,; R5 is an optionally substituted 5-membered heteroaromatic ring, R1, R2 ,R3, R4 are independently selected from various specified moieties, in the preparation of a medicament for use in the inhibition of aurora 2 kinase. Certain compounds are novel and these, together with pharmaceutical compositions containing them are also described and claimed