2879-20-1

Basic information

• Product Name: 6-Acetyl-1,4-benzodioxane
• Synonyms: AURORA 18707;ASISCHEM D29259;6-ACETYL-1,4-BENZODIOXANE;AKOS BBS-00006494;3',4'-ETHYLENEDIOXYACETOPHENONE;1-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)ETHAN-1-ONE;1-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)ETHANONE;1-(2,3-DIHYDROBENZO[B][1,4]DIOXIN-7-YL)ETHANONE
• CAS NO: 2879-20-1
• Molecular Formula: C₁₀H₁₀O₃
• Molecular Weight: 178.18
• EINECS: 220-726-3
• Product Categories: BenzodioxanesCarbonyl Compounds;Building Blocks;C10;Heterocyclic Building Blocks;Ketones
• Mol File: 2879-20-1.mol
• Article Data: 6

Chemical Properties

• Melting Point: 80-82 °C(lit.)
• Boiling Point: 270.41°C (rough estimate)
• Flash Point: 134.5 °C
• Appearance: Almost white to slightly blue/Fine Crystalline Needles
• Density: 1.1601 (rough estimate)
• Vapor Pressure: 0.000487mmHg at 25°C
• Refractive Index: 1.5370 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• BRN: 164125
• CAS DataBase Reference: 6-Acetyl-1,4-benzodioxane(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Acetyl-1,4-benzodioxane(2879-20-1)
• EPA Substance Registry System: 6-Acetyl-1,4-benzodioxane(2879-20-1)

Safety Data

• Hazard Codes: Xi
• Safety Statements: 24/25-25-24
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 2879-20-1(Hazardous Substances Data)

Usage

Chemical Properties

ALMOST WHITE TO SLIGHTLY BLUE FINE CRYST. NEEDLES

Uses

1,4-Benzodioxan-6-yl methyl ketone may be used in the preparation of acetylenic alcohols.

InChI:InChI=1/C10H10O3/c1-7(11)8-2-3-9-10(6-8)13-5-4-12-9/h2-3,6H,4-5H2,1H3

Upstream product

• 29668-44-8 2,3-dihydro-benzo[1,4]dioxin-6-carbaldehyde 
• 7338-03-6 1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)ethan-1-ol 
• 493-09-4 benzo-1,4-dioxane 
• 108-24-7 acetic anhydride 
• 1197-09-7 1-(3,4-dihydroxyphenyl)ethan-1-one 
• 106-93-4 ethylene dibromide 
• 75-36-5 acetyl chloride 

Downstream Products

• 74604-76-5 enoxamast 
• 17253-11-1 2,3-dihydro-1,4-benzodioxin-6-ylacetic acid 
• 74053-94-4 ethyl 3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-oxopropanoate 
• 105362-06-9 2-amino-4-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-thiazole 
• 4629-54-3 2-bromo-1-(2,3-dihydro-1,4-benzodioxin-6-yl)ethanone 
• 4442-54-0 2,3-dihydro-1,4-benzodioxin-6-carboxylic acid 

Relevant articles and documents

Unusual behaviour of 7-diethylamino-3-(3,4-ethylen-dioxybenzoyl)coumarin towards Group IIA cations: A potential photoactive probe for magnesium

The titled compound showed, upon spectrophotometric titrations with Group II cations, a spectacular bathochromic shift (c.a. 50 nm) with Mg2+ but not with the other cations. This result is - understood in terms of internal charge-transfer species expressly favored by Et2N and ArCO substituents and best matching of ionic diameter and charge density of Mg2+. This finding may lead to new simple photoactive probes.

Design, synthesis and pharmacology of 1,1-bistrifluoromethylcarbinol derivatives as liver X receptor β-selective agonists

A novel series of 1,3-bistrifluoromethylcarbinol derivatives that act as liver X receptor (LXR) β-selective agonists was discovered. Structure-activity relationship studies led to the identification of molecule 62, which was more effective (Emax) and selective toward LXRβ than T0901317 and GW3965. Furthermore, 62 decreased LDL-C without elevating the plasma TG level and significantly suppressed the lipid-accumulation area in the aortic arch in a Bio F1B hamster fed a diet high in fat and cholesterol. We demonstrated that our LXRβ agonist would be potentially useful as a hypolipidemic and anti-atherosclerotic agent. In this manuscript, we report the design, synthesis and pharmacology of 1,3-bistrifluoromethylcarbinol derivatives.

Synthesis and anti-inflammatory activity of rac-2-(2,3-dihydro-1,4-benzodioxin)propionic acid and its R and S enantiomers

Racemic (R,S)-2-(2,3-dihydro-1,4-benzodioxin-6-yl)propionic acid (3) has been prepared from 2,3-dihydro-1,4-benzodioxin. R-(-)-Pantolactone has been used as auxiliary for the synthesis of R-3 and S-3. The anti-inflammatory properties of the new carboxylic acids are described and compared with other anti-inflammatory agents. The highest activity is exhibited by compound S-3.