288-36-8Relevant articles and documents
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Wiley et al.
, p. 190 (1956)
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Method for preparing high-purity 1H-1, 2, 3-triazole
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Paragraph 0028; 0031-0033; 0036-0038; 0041-0042, (2021/07/17)
The invention belongs to the technical field of chemicals, and particularly relates to a method for preparing high-purity 1H-1, 2, 3-triazole, 1H-1, 2, 3-triazole is prepared from the following chemical materials: glyoxal, hydrates, hydroxylamine hydrochloride, ethyl acetate, toluene, acetic anhydride and absolute methanol, wherein the concentration ofglyoxal is 40%, the concentration of the hydrate is 85%, the preparation of the 1H-1, 2, 3-triazole comprises four steps, namely, the first step of synthesis of monooxime hydrazone, the second step of synthesis of oxime acylhydrazone, the third step of synthesis of diacyloxime hydrazone and the fourth step of synthesis of triazole, the preparation method is easy to operate, common chemical experiment operation is adopted, the reaction conditions are simple, control is easy, the concentration of the prepared 1H-1, 2, 3-triazole is high, no pollutant is generated in the preparation process, the environment is not polluted, no danger is generated in the preparation process, no danger is generated in the experiment process, and the method is simple, easy to operate and safe.
Method for continuously synthesizing 1H-1,2,3-triazole by using microchannel reactor
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Paragraph 0020; 0046; 0049-0052; 0055-0058; 0061-0063, (2021/05/19)
The invention relates to a method for continuously synthesizing 1H-1,2,3-triazole through a microchannel reactor, and belongs to the technical field of medicine synthesis. The method comprises the following steps: reacting a hydrazine hydrate aqueous solution and a glyoxal aqueous solution in a micro-channel reactor to prepare a material 1, continuously reacting the material 1 with hydrogen peroxide in the micro-channel reactor to prepare a material 2, and continuously mixing the material 2 with concentrated hydrochloric acid in the micro-channel reactor to obtain a material 3; conducting reaction on the material 3 and a sodium nitrite aqueous solution in the micro-channel reactor, and conducting post-treatment to obtian 1H-1,2,3-triazole. No solvent needs to be added or replaced in the reaction process, manganese dioxide and potassium permanganate which can generate solid waste are prevented from being used, and toxic substances such as toluenesulfonyl chloride and dioxane which are harmful to the environment are not used either; and the 1H-1,2,3-triazole can be safely produced.