2883-45-6Relevant articles and documents
-
Kerber,R.C.,Hsu,C.-M.
, p. 3239 - 3245 (1973)
-
Oxa/thiazole-tetrahydropyran triazole-linked hybrids with selective antiproliferative activity against human tumour cells
Valdomir, Guillermo,Fernández,Lagunes, Irene,Padrón, Juan I.,Martín, Víctor S.,Padrón, José M.,Davyt, Danilo
, p. 13784 - 13789 (2018)
Inspired by diverse marine bioactive compounds, the principle of molecular hybridization was applied to produce a series of new compounds combining diverse heterocyclic systems (oxa/thiazoles and tetrahydropyrans) via a triazole ring, attempting to increase the activity of individual building blocks. These new compounds exhibit a highly interesting antiproliferative activity against different human tumour cells and good selectivity when compared to normal cells. The formation of reactive oxygen species and the interaction with P-gp were also evaluated for the lead compounds.
Perfluoroalkylated Calix[4]pyrroles: Fluoride Ion Extraction from an Aqueous Medium
Maji, Sinchan,Mandal, Debaprasad
, p. 2369 - 2373 (2017)
Octaalkenyl calix[4]pyrrole ((CH2=CH(CH2)2)8C4P) is highly useful for the postfunctionalization of different calix[4]pyrroles with desired functionalities. Functionalization with perfluoroalkyl chains [CF3(CF2)n; Rfn] gave perfluoroalkyl calix[4]pyrroles (Rfn(CH2)4)8C4P; n=6, 8), having >60 % fluorine content, which created a hydrophobic environment inside the calix[4]pyrrole cavity and recognized fluoride and chloride ions in solution as well as in the solid state. The fluoride ion is extracted efficiently from aqueous CsF and TBAF solutions by using (Rf6(CH2)4)8C4P, as droplets. The fluorinated chain generated a hydrophobic environment which broke the hydration shell associated with the anion and separated out fluoride ions as droplets from aqueous medium. Furthermore, the fluoride ions competitively replaced chloride ions from the (Rf6(CH2)4)8C4P cavity.
Synthesis of 1,3-Cycloalkadienes from Cycloalkenes: Unprecedented Reactivity of Oxoammonium Salts
Nagasawa, Shota,Sasano, Yusuke,Iwabuchi, Yoshiharu
supporting information, p. 13189 - 13194 (2016/10/30)
Few methods allow for the direct conversion of cycloalkenes into cycloalkadienes with high chemo- and regioselectivity. Herein, we report a convenient one-pot process for this transformation that involves the unprecedented N-preferential group transfer of N-oxoammonium salts to cycloalkenes, followed by Cope elimination, to afford cycloalkadienes at room temperature and pressure.
Synthesis and antiviral evaluation of novel 2′,2′-difluoro 5′-norcarbocyclic phosphonic acid nucleosides as antiviral agents
Shen, Guang Huan,Hong, Joon Hee
, p. 1 - 17 (2014/03/21)
A very efficient synthetic route to novel 2′,2′-difluoro 5′-norcarbocyclic phosphonic acid nucleosides from but-3-en-1-ol 5 is described. The discovery of 2′-fluorinated furanose nucleoside 1 as a potent anti-HIV-1 agent has led to the synthesis and biological evaluation of 2′-modified 5′-norversions of the carbocyclic phosphonate nucleosides. The synthesized nucleoside analogues 18, 19, 23a, 23b, and 24 were tested for anti-HIV activity as well as cytotoxicity. Adenine analogue 19 shows significant anti-HIV-1 activity (EC50 = 13 μM).