289686-69-7

Basic information

• Product Name: 2-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-propionyl chloride
• Synonyms: 2-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-propionyl chloride
• CAS NO: 289686-69-7
• Molecular Weight: 318.646
• Mol File: 289686-69-7.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 2-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-propionyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-propionyl chloride(289686-69-7)
• EPA Substance Registry System: 2-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-propionyl chloride(289686-69-7)

Safety Data

• Hazardous Substances Data: 289686-69-7(Hazardous Substances Data)

Usage

Derivative of propionyl chloride

2-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-propionyl chloride is derived from propionyl chloride by attaching two 3,5-bis-trifluoromethyl-phenyl groups to the second carbon atom.

Reagent in organic synthesis

This compound is commonly used as a reagent in organic synthesis, particularly for the acylation of various substrates.

Physical properties

It is a colorless, volatile liquid with a pungent odor.

Hazardous substance

Due to its corrosive and toxic nature, 2-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-propionyl chloride is considered a hazardous substance.

Highly reactive

This compound is known for its high reactivity, which necessitates careful handling in a controlled laboratory environment.

Upstream product

• 79-37-8 oxalyl dichloride 
• 289686-70-0 α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid 
• 67570-38-1 α,α-dimethyl-3,5-bis(trifluoromethyl)benzenemethanol 
• 328-70-1 3,6-bis(trifluoromethyl)bromobenzene 

Downstream Products

• 290297-26-6 netupitant 
• 401891-53-0 2-(3,5-bis-trifluoromethyl-phenyl)-N-[6-chloro-4-(2-chloro-phenyl)-pyridin-3-yl]-N-methyl-isobutyramide 
• 825643-73-0 2-(3,5-bis(trifluoromethyl)phenyl)-N-(6-chloro-4-(4-fluoro-2-methylphenyl)pyridin-3-yl)-N,2-dimethylpropanamide 

Relevant articles and documents

NEW CHEMICAL PROCESS FOR MAKING 6-CHLORO-4-(4-FLUORO-2-METHYLPHENYL)PYRIDIN-3-AMINE A KEY INTERMEDIATE OF NT-814

The invention relates to a new process for producing compound 2-(3,5-bis(trifluoromethyl)phenyl)-N-(6-chloro-4-(4-fluoro-2-methylphenyl)pyridin-3-yl)-N,2-dimethylpropanamide (Compound IX) which is useful in the manufacture of compound 2-[3,5-Bis(trifluoro

CARBOXYMETHYL PIPERIDINE DERIVATIVE

The present invention provides a new compound which has NK1 receptor antagonist activity, whose CYP3A4 inhibitory activity is reduced compared to aprepitant, and which are useful for the prevention or treatment of cancer-chemotherapy-induced nausea and vomiting. That is, the present invention relates to carboxymethyl piperidine derivatives represented by the following formula (I) or a pharmaceutically acceptable salt thereof. Wherein, ring A is a benzene ring or the like; ring B is a pyridine ring or the like; R1 is C1-6 alkyl or C1-6 alkoxy; R2 and R3 are a hydrogen atom or methyl; and n is an integral number from 0 to 5.

Substituted 4-phenyl pyridines having anti-emetic effect

Disclosed are compounds, compositions and methods for the prevention and/or treatment of diseases which are pathophysiologically mediated by the neurokinin (NK1) receptor. The compounds have the general formula (I):