29126-13-4

Basic information

• Product Name: 3-hydroxymethyl-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid diphenylmethyl ester
• Synonyms: 3-hydroxymethyl-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid diphenylmethyl ester
• CAS NO: 29126-13-4
• Molecular Weight: 520.63
• Mol File: 29126-13-4.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 3-hydroxymethyl-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid diphenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxymethyl-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid diphenylmethyl ester(29126-13-4)
• EPA Substance Registry System: 3-hydroxymethyl-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid diphenylmethyl ester(29126-13-4)

Safety Data

• Hazardous Substances Data: 29126-13-4(Hazardous Substances Data)

Upstream product

• 957-68-6 7-Aminocephalosporanic acid 
• 5935-65-9 Desacetylcephalothin 
• 5350-57-2 benzophenone hydrazone 
• 39098-97-0 2-thienylacetic acid chloride 
• 15690-38-7 (6R,7R)-7-amino-3-hydroxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
• 908093-98-1 diazodiphenylmethane 

Downstream Products

• 41906-86-9 Nitrocefin 
• 30361-56-9 (6R)-3-bromomethyl-8-oxo-7t-(2-thiophen-2-yl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 134479-98-4 benzhydryl 7β-(2-(thien-2-yl)acetamido)-3-<<<(4-nitrophenoxy)carbonyl>oxy>methyl>-2-cephem-4-carboxylate 
• 135508-68-8 3-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid diphenylmethyl ester 
• 1107637-76-2 C₃₄H₂₇N₃O₁₂S₂ 
• 141555-09-1 7-{2-(2-aminothiazol-4-yl)-2-[(Z)-(1-carboxy-1-methylethoxy)imino]acetamido}-3-{[(3-bromo-4,5-dihydroxybenzoyl)oxy]methyl}ceph-3-em-4-carboxylic acid 
• 141613-33-4 (6R,7R)-7-Amino-3-(3,4-diacetoxy-5-bromo-benzoyloxymethyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 141613-43-6 diphenylmethyl 7-<2-(2-aminothiazol-4-yl)-2-<<(Z)-1-(tert-butoxycarbonyl)-1-methylethoxy>imino>acetamido>-3-<<(3-bromo-4,5-diacetoxybenzoyl)oxy>methyl>ceph-3-em-4-carboxylate 
• 141613-44-7 diphenylmethyl 7-<2-(2-aminothiazol-4-yl)-2-<<(Z)-1-(tert-butoxycarbonyl)-1-methylethoxy>imino>acetamido>-3-<<(3,4-diacetoxybenzoyl)oxy>methyl>ceph-3-em-4-carboxylate 
• 118680-12-9 7-<2-(2-aminothiazol-4-yl)-2-<(Z)-(1-carboxy-1-methylethoxy)imino>acetamido>-3-<<(3,4-dihydroxybenzoyl)oxy>methyl>ceph-3-em-4-carboxylic acid 
• 118679-75-7 Diphenylmethyl (6R,7R)-7-amino-3-(3,4-diacetoxybenzoyloxy)methylceph-3-em-4-carboxylate 
• 119733-54-9 7-<2-(2-aminothiazol-4-yl)-2-<(Z)-(1-carboxy-1-methylethoxy)imino>acetamido>-3-<<(3-bromo-4,5-dihydroxybenzoyl)oxy>methyl>ceph-3-em-4-carboxylic acid 
• 142966-79-8 (6R,7R)-3-(Morpholine-4-carbonyloxymethyl)-8-oxo-7-{2-[2-(trityl-amino)-thiazol-4-yl]-2-[(Z)-trityloxyimino]-acetylamino}-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 142966-76-5 (6R,7R)-3-[(Ethyl-methyl-carbamoyloxy)-methyl]-8-oxo-7-{2-[2-(trityl-amino)-thiazol-4-yl]-2-[(Z)-trityloxyimino]-acetylamino}-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 

Relevant articles and documents

FLUOROGENIC BETA-LACTAMASE SUBSTRATE AND ASSOCIATED DETECTION METHOD

This invention relates to probes for the detection of β-lactamase-type enzymatic activity. In particular, the invention relates to novel fluorogenic substrates for detecting the presence of a catalytically active β-lactamase and a detection method using such substrates.

Nitrocefin synthesis method

The invention relates to a nitrocefin synthesis method and belongs to the field of drug synthesis. The invention provides a novel process for preparing nitrocefin from a compound I as a raw material. The compound I is prepared from 7-ACA. The nitrocefin synthesis method can realize synthesis of nitrocefin from 7-ACA as an initial raw material through seven processes. The 7-ACA as an initial raw material is a key intermediate of a cephalosporin, has already been industrialized and has a low market price. The nitrocefin synthesis method has the advantages of simple processes, easy reaction treatment, easy product purification, high yield, easy industrialization and low production cost.

Synthesis of beta-lactamase activated nitric oxide donors

In order to achieve site specific delivery of NO, we designed conjugates of cephalosporin with NO donors. NO donors such as cupferron and SIN-1 were evaluated as potential choices for conjugates. Cephalosporin conjugated with SIN-1 demonstrated promising beta-lactamase dependent NO releasing ability.