2927-34-6

Basic information

• Product Name: 3,4-Difluorotoluene
• Synonyms: 3,4-DIFLUOROTOLUENE;3.4-Difluoro methyl benzene;3,4-Difluorobenzene;3,4-Difluorotoluene 99%;3,4-Difluorotoluene99%;3,4-DIFLUOROTOLUENE 98+%;1,2-Difluoro-4-methylbenzene;3.4-difluoro-Trifluoromethoxy
• CAS NO: 2927-34-6
• Molecular Formula: C7H6F2
• Molecular Weight: 128.12
• EINECS: 1533716-785-6
• Product Categories: Fluorin-contained toluene series;Aromatic Hydrocarbons (substituted) & Derivatives;Halogen toluene;Miscellaneous;Aryl;C7;Halogenated Hydrocarbons;Fluorinated benzene series
• Mol File: 2927-34-6.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 110-113 °C(lit.)
• Flash Point: 77 °F
• Appearance: /Liquid
• Density: 1.12 g/mL at 25 °C(lit.)
• Vapor Pressure: 26.7mmHg at 25°C
• Refractive Index: n20/D 1.45(lit.)
• Storage Temp.: Flammables area
• Water Solubility: Insoluble in water.
• CAS DataBase Reference: 3,4-Difluorotoluene(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-Difluorotoluene(2927-34-6)
• EPA Substance Registry System: 3,4-Difluorotoluene(2927-34-6)

Safety Data

• Hazard Codes: F
• Statements: 10
• Safety Statements: 16-29-33
• RIDADR: UN 1993 3/PG 3
• WGK Germany: 3
• HazardClass: 3
• PackingGroup: II
• Hazardous Substances Data: 2927-34-6(Hazardous Substances Data)

Usage

Chemical Properties

colorless to light yellow liqui

Uses

Used as pharmaceutical intermediate.

InChI:InChI=1/C7H6F2/c1-5-2-3-6(8)7(9)4-5/h2-4H,1H3

Upstream product

• 367-11-3 ortho-difluorobenzene 
• 348-61-8 1-bromo-3,4-difluorobenzene 
• 74-88-4 methyl iodide 
• 116850-27-2 2-chloro-1,1,2-trifluoro-3-isopropenylcyclobutane 
• 4265-28-5 2-chloro-1,1,2-trifluoro-3-methyl-3-vinylcyclobutane 
• 79-38-9 Chlorotrifluoroethylene 
• 78-79-5 isoprene 
• 108-88-3 toluene 

Downstream Products

• 34036-07-2 3,4 difluorobenzaldehyde 
• 1003712-18-2 2,3-difluoro-5-methylbenzonitrile 
• 886038-03-5 1,2-difluoro-3-iodo-5-methylbenzene 

Relevant articles and documents

Two-step regioselective synthesis of 1,2-difluorobenzenes from chlorotrifluoroethylene and buta-l,3-dienes

The gas-phase copyrolysis of chlorotrifluoroethylene with buta-1,3-diene, penta-1,3-diene, or isoprene in a flow reactor at 440–480°C gave 4-chloro-4,5,5-trifluorocyclohex-1-enes. The latter treated with aqueous KOH under condition of phase-transfer catalysis were selectively converted into 1,2-difluorobenzene, 2,3-difluorotoluene, or 3,4-difluorotoluene.

LIQUID CRYSTALLINE COMPOUND HAVING DIBENZOTHIOPHENE RING, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY ELEMENT

PROBLEM TO BE SOLVED: To provide a liquid crystalline compound satisfying at least one of physical properties such as high stability to heat or light, a high clear point, a low minimum temperature of a liquid crystal phase, small viscosity, appropriate optical anisotropy, negatively large dielectric anisotropy, an appropriate elastic constant and good compatibility with other liquid crystalline compounds, a liquid crystal composition containing the compound, and a liquid crystal display element containing the composition. SOLUTION: The compound is represented by formula (1), and the liquid crystal composition contains the above compound. In the formula, R1 and R2 represent an alkyl having 1 to 16 carbon atoms, or the like; A1 to A2 represent 1,4-cyclohexylene or the like; Z1 and Z2 represent a single bond or the like; m1 and n1 represent 0, 1 or 2; W represents -S- or the like; X represents H or F; and Y1 to Y4 represent H or a methyl. SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT

Method of preparing fluoroaromatic compounds

The present invention provides a method of preparing ortho-difluorobenzene derivatives, which comprises (a) providing a mixture of cyclohexenes by reacting chlorotrifluoroethylene (CTFE) and 1,3-diene in a flow reactor and distilling the resultant, and (b) dehydrohalogenating the mixture of cyclohexenes with a phase transition catalyst in the presence of alkali metal hydroxide at temperature range of 40 to 150 °C without using any organic solvent. The distillate having low boiling point, which is obtained during distillation of the resultant, is recycled into the flow reactor. The present invention also provides a method of preparing 2-chloro-4,5-difluorobenzoic acid, which comprises (a) providing a mixture of 4-chloro-1-methyl-4,5,5-trifluorocyclohexene and 5-chloro-1-methyl-4,4,5-trifluorocyclohexene by reacting chlorotrifluoroethylene (CTFE) and isoprene and distilling the resultant, (b) dehydrohalogenating said mixture in the presence of alkali metal hydroxide and a phase transition catalyst to form 3,4-difluorotoluene, (c) reacting said 3,4-difluorotoluene with chlorine gas without using any organic solvent to form 2-chloro-4,5-difluorotoluene, (d) photo-reacting said 2-chloro-4,5-difluorotoluene with chlorine gas under a lighting mercury lamp without using any organic solvent to form 2-chloro-4,5-difluorobenzotrichloride, and (e) reacting said 2-chloro-4,5-difluorobenzotrichloride with aqueous acid solution without using any organic solvent. The present invention also provides a method of preparing 2-chloro-4,5-difluorobenzoyl chloride by reacting the 2-chloro-4,5-difluorobenzotrichloride of step (e) above with zinc oxide.