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29578-83-4

29578-83-4

Identification

  • Product Name:1-bromo-3-methoxy-5-methylbenzene

  • CAS Number: 29578-83-4

  • EINECS:

  • Molecular Weight:201.063

  • Molecular Formula: C8H9BrO

  • HS Code:2909309090

  • Mol File:29578-83-4.mol

Synonyms:Anisole,3-bromo-5-methyl- (8CI);1-Bromo-3-methoxy-5-methylbenzene;1-Bromo-5-methoxy-3-methylbenzene;3-Bromo-5-methoxytoluene;3-Bromo-5-methylanisole;3-Methyl-5-methoxyphenyl bromide;5-Bromo-3-methoxytoluene;

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Safety information and MSDS view more

  • Pictogram(s):Xn

  • Hazard Codes:Xn

  • Signal Word:Warning

  • Hazard Statement:H315 Causes skin irritationH319 Causes serious eye irritation H335 May cause respiratory irritation

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

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  • Product Description
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  • Purchase
  • Manufacture/Brand:TRC
  • Product Description:3-Bromo-5-methylanisole
  • Packaging:10g
  • Price:$ 325
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:TRC
  • Product Description:3-Bromo-5-methylanisole
  • Packaging:25g
  • Price:$ 745
  • Delivery:In stock
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  • Manufacture/Brand:TRC
  • Product Description:3-Bromo-5-methylanisole
  • Packaging:1g
  • Price:$ 110
  • Delivery:In stock
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  • Manufacture/Brand:TRC
  • Product Description:3-Bromo-5-methylanisole
  • Packaging:500mg
  • Price:$ 85
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:3-Bromo-5-methoxytoluene >98.0%(GC)
  • Packaging:1g
  • Price:$ 16
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:3-Bromo-5-methoxytoluene >98.0%(GC)
  • Packaging:5g
  • Price:$ 40
  • Delivery:In stock
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  • Manufacture/Brand:Medical Isotopes, Inc.
  • Product Description:3-Bromo-5-methylanisole
  • Packaging:5 g
  • Price:$ 1880
  • Delivery:In stock
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  • Manufacture/Brand:Labseeker
  • Product Description:1-BROMO-3-METHOXY-5-METHYLBENZENE 95
  • Packaging:500g
  • Price:$ 692
  • Delivery:In stock
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  • Manufacture/Brand:Crysdot
  • Product Description:1-Bromo-3-methoxy-5-methylbenzene 97%
  • Packaging:100g
  • Price:$ 356
  • Delivery:In stock
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  • Manufacture/Brand:Chemenu
  • Product Description:1-Bromo-3-methoxy-5-methylbenzene 95+%
  • Packaging:25g
  • Price:$ 122
  • Delivery:In stock
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Relevant articles and documentsAll total 13 Articles be found

Preparation process for 3-methyl-5-methoxybenzenesulfonyl chloride

-

, (2018/01/12)

The invention discloses a preparation process for 3-methyl-5-methoxybenzenesulfonyl chloride. The process comprises the following steps: 3,5-dibromotoluene is used as an initial raw material, the 3,5-dibromotoluene is subjected to a boronic acidification reaction, thus 3-methyl-5-bromophenylboronic acid is obtained, the 3-methyl-5-bromophenylboronic acid is subjected to an oxidation reaction, thus 3-methyl-5-bromophenol is obtained, the 3-methyl-5-bromophenol is subjected to a substitution reaction, thus 3-methyl-5-bromoanisoles is obtained, the 3-methyl-5-bromoanisoles is subjected to sulfonation, thus 3-methyl-5-methoxybenzenesulfonate is obtained, the 3-methyl-5-methoxybenzenesulfonate is subjected to a substitution reaction, and therefore the objective compound 3-methyl-5-methoxybenzenesulfonyl chloride is obtained. According to the above route, the raw materials are easy to obtain, post-treatment is simple, convenient and easy to implement, a yield is relatively high, and the process has relatively-good application value.

HETEROCYCLIC CARBOXYLIC ACIDS AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE

-

Paragraph 0324-0325, (2016/02/18)

The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R5, R6, R7, R8, R9, B, V, W, X, Y, Z and m are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

ALKOXY PYRAZOLES AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS

-

Paragraph 0297; 0313, (2014/03/25)

The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6 and R7 are as defined herein. The inventi

17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS FOR THE TREATMENT OF HORMONE-RELATED DISEASES

-

Page/Page column 13-14, (2010/08/18)

The invention relates to the use of non-steroidal 17beta-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment and prophylaxis of hormone-dependent, particularly estrogen-dependent, diseases.The invention further relates to suitable inhibitors and to a method for the production thereof.

NOVEL HIV REVERSE TRANSCRIPTASE INHIBITORS

-

Page/Page column 423, (2009/03/07)

The invention is related to compounds of Formula (I) or a pharmaceutically acceptable salt, solvate, ester, and/ or phosphonate thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.

Process route upstream and downstream products

Process route

4-bromo-2-methoxy-6-methyl-phenylamine
348169-39-1

4-bromo-2-methoxy-6-methyl-phenylamine

3-bromo-5-methoxytoluene
29578-83-4

3-bromo-5-methoxytoluene

Conditions
Conditions Yield
4-bromo-2-methoxy-6-methyl-phenylamine; With hydrogenchloride; sodium nitrite; In water; acetic acid; at 0 ℃; for 0.5h;
With hypophosphorous acid; In water; acetic acid; at 0 - 20 ℃;
95%
4-bromo-2-methoxy-6-methyl-phenylamine; With hydrogenchloride; acetic acid; sodium nitrite; In water; for 0.5h; Cooling with ice;
With hypophosphorous acid; In water; at 0 - 20 ℃;
90%
4-bromo-2-methoxy-6-methyl-phenylamine; With hydrogenchloride; sodium nitrite; In acetic acid; at 0 ℃; for 0.75h;
With hypophosphorous acid; at 0 - 20 ℃;
85%
4-bromo-2-methoxy-6-methyl-phenylamine; With hydrogenchloride; acetic acid; sodium nitrite; for 0.5h;
With hypophosphorous acid; at 0 ℃; for 8h;
80%
4-bromo-2-methoxy-6-methyl-phenylamine; With hydrogenchloride; acetic acid; sodium nitrite; for 0.5h;
at 0 ℃; for 8h; Further stages.;
80%
4-bromo-2-methoxy-6-methyl-phenylamine; With hydrogenchloride; sodium nitrite; In water; acetic acid; at 0 ℃; for 0.5h;
With hypophosphorous acid; In water; acetic acid; at 0 - 20 ℃; for 56h;
4-bromo-2-methoxy-6-methyl-phenylamine; With hydrogenchloride; acetic acid; sodium nitrite; In water; at 0 ℃; for 0.5h;
With hypophosphorous acid; In water; at 0 - 20 ℃; for 56h;
Multi-step reaction with 2 steps
1: hydrogenchloride; sodium nitrite
2: hypophosphorous acid
With hydrogenchloride; hypophosphorous acid; sodium nitrite;
3-bromo-5-methylphenol
74204-00-5

3-bromo-5-methylphenol

methyl iodide
74-88-4

methyl iodide

3-bromo-5-methoxytoluene
29578-83-4

3-bromo-5-methoxytoluene

Conditions
Conditions Yield
With potassium carbonate; In acetone; at 40 ℃; for 16h; Temperature;
100%
With potassium carbonate; In acetonitrile; for 3h; Solvent; Reagent/catalyst; Reflux;
85.8%
With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 24h; Solvent; Temperature; Time;
52%
3,5-dibromoanisole
74137-36-3

3,5-dibromoanisole

methyl iodide
74-88-4

methyl iodide

3-bromo-5-methoxytoluene
29578-83-4

3-bromo-5-methoxytoluene

Conditions
Conditions Yield
3,5-dibromoanisole; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.25h;
methyl iodide; In tetrahydrofuran; at -20 ℃; for 2h;
3-bromo-5-methylphenol
74204-00-5

3-bromo-5-methylphenol

3-bromo-5-methoxytoluene
29578-83-4

3-bromo-5-methoxytoluene

Conditions
Conditions Yield
With sodium hydroxide; dimethyl sulfate; In water;
2-methoxy-6-methylbenzeneamine
50868-73-0

2-methoxy-6-methylbenzeneamine

3-bromo-5-methoxytoluene
29578-83-4

3-bromo-5-methoxytoluene

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1.1: 80 percent / Br2; AcOH / methanol / 2 h
2.1: NaNO2; AcOH; aq. HCl / 0.5 h
2.2: 80 percent / 50percent aq. H3PO2 / 8 h / 0 °C
With hydrogenchloride; bromine; acetic acid; sodium nitrite; In methanol;
Multi-step reaction with 2 steps
1.1: 87 percent / Br2; glacial acetic acid / methanol / 2 h / cooling
2.1: NaNO2; aq. HCl / acetic acid / 0.75 h / 0 °C
2.2: 85 percent / aq. hypophosphorous acid / 0 - 20 °C
With hydrogenchloride; bromine; acetic acid; sodium nitrite; In methanol; acetic acid;
Multi-step reaction with 2 steps
1.1: 80 percent / Br2; AcOH / methanol / 2 h
2.1: NaNO2; AcOH; aq. HCl / 0.5 h
2.2: 80 percent / 50 percent aq. H3PO2 / 8 h / 0 °C
With hydrogenchloride; bromine; acetic acid; sodium nitrite; In methanol;
Multi-step reaction with 3 steps
1: bromine; acetic acid
2: hydrogenchloride; sodium nitrite
3: hypophosphorous acid
With hydrogenchloride; bromine; hypophosphorous acid; acetic acid; sodium nitrite;
Multi-step reaction with 2 steps
1.1: bromine; acetic acid / methanol / 2 h / 20 °C
2.1: hydrogenchloride; acetic acid; sodium nitrite / water / 0.5 h / 0 °C
2.2: 56 h / 0 - 20 °C
With hydrogenchloride; bromine; acetic acid; sodium nitrite; In methanol; water;
3-bromo-5-methylphenol
74204-00-5

3-bromo-5-methylphenol

dimethyl sulfate
77-78-1

dimethyl sulfate

3-bromo-5-methoxytoluene
29578-83-4

3-bromo-5-methoxytoluene

Conditions
Conditions Yield
With potassium carbonate; In acetone; for 4h; Heating;
99%
With sodium hydroxide;
C<sub>8</sub>H<sub>8</sub>BrN<sub>2</sub>O<sup>(1+)</sup>*Cl<sup>(1-)</sup>
1357103-83-3

C8H8BrN2O(1+)*Cl(1-)

3-bromo-5-methoxytoluene
29578-83-4

3-bromo-5-methoxytoluene

Conditions
Conditions Yield
With hypophosphorous acid;
2,3,4,6-tetrabromo-5-methyl-phenol
58169-99-6

2,3,4,6-tetrabromo-5-methyl-phenol

3-bromo-5-methoxytoluene
29578-83-4

3-bromo-5-methoxytoluene

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: 83 percent / aluminium chloride / benzene / 0.5 h / Heating
2: 99 percent / potassium carbonate / acetone / 4 h / Heating
With aluminium trichloride; potassium carbonate; In acetone; benzene;
3-methyl-phenol
108-39-4

3-methyl-phenol

3-bromo-5-methoxytoluene
29578-83-4

3-bromo-5-methoxytoluene

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: 77 percent / bromine, aluminium powder
2: 83 percent / aluminium chloride / benzene / 0.5 h / Heating
3: 99 percent / potassium carbonate / acetone / 4 h / Heating
With aluminium trichloride; bromine; potassium carbonate; aluminium; In acetone; benzene;
3,5-dibromotoluene
1611-92-3

3,5-dibromotoluene

3-bromo-5-methoxytoluene
29578-83-4

3-bromo-5-methoxytoluene

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: n-butyllithium / tetrahydrofuran / 2.5 h / -78 °C / Inert atmosphere
2: potassium hydroxide; dihydrogen peroxide / water / 0.33 h / 20 °C
3: potassium carbonate / acetonitrile / 3 h / Reflux
With n-butyllithium; dihydrogen peroxide; potassium carbonate; potassium hydroxide; In tetrahydrofuran; water; acetonitrile;

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  • Chemwill Asia Co., Ltd.
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  • Win-Win chemical Co.Ltd
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