296250-53-8Relevant articles and documents
Substituted pyrazolopyridopyridazines as orally bioavailable potent and selective PDE5 inhibitors: Potential agents for treatment of erectile dysfunction
Yu, Guixue,Mason, Helen,Wu, Ximao,Wang, Jian,Chong, Saeho,Beyer, Bruce,Henwood, Andrew,Pongrac, Ronald,Seliger, Laurie,He, Bin,Normandin, Diane,Ferrer, Pam,Zhang, Rongan,Adam, Leonard,Humphrey, William G.,Krupinski, John,Macor, John E.
, p. 457 - 460 (2003)
Novel pyrazolopyridopyridazine derivatives have been prepared as potent and selective PDE5 inhibitors. Compound 6 has been identified as a more potent and selective PDE5 inhibitor than sildenafil (1). It is as efficacious as sildenafil in in vitro and in
Fused pyridopyridazine inhibitors of cGMP phosphodiesterase
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, (2008/06/13)
Compounds of the formula are useful as inhibitors of cGMP PDE especially Type 5.