2972-82-9Relevant articles and documents
An Efficient Access to Pyrimidine-based Polyfunctional Heterocycles with Anticipated Antibacterial Activity
Mourad, Asmaa Kamal,Mohammed, Fatehia K.,Tammam, Gamal Hassan,Mohammed, Shimaa Rabie
, p. 2262 - 2273 (2019)
6-Amino-2-thioxotetrahydropyrimidine-5-carbonitrile derivative 2 was synthesized in a good yield via refluxing a mixture of arylidene 1 and thiourea in a highly basic sodium ethoxide solution. Subsequently, the synthesized pyrimidine-2-thione derivative 2 was allowed to interact with diversified nucleophiles and electrophiles under various reaction conditions in order to have a feasible access to further new and assorted fused heterocycles. Finally, the biological activity of the newly synthesized fused pyrimidines was screened in vitro against four different Gram-positive and Gram-negative bacterial strains. All the developed heterocycles were adequately characterized utilizing 1H-NMR, 13C-NMR, Fourier transform infrared, elemental analysis, and electrospray ionization–mass spectrum and tested for their antibacterial activity.
Discovery of Highly Potent Adenosine A1Receptor Agonists: Targeting Positron Emission Tomography Probes
Guo, Min,Bakhoda, Abolghasem,Gao, Zhan-Guo,Ramsey, Joseph M.,Li, Yang,O'Conor, Kelly A.,Kelleher, Andrew C.,Eisenberg, Seth M.,Kang, Yeona,Yan, Xuefeng,Javdan, Cameron,Fowler, Joanna S.,Rice, Kenner C.,Hooker, Jacob M.,Jacobson, Kenneth A.,Kim, Sung Won,Volkow, Nora D.
, (2021/09/27)
Adenosine receptor (AR) radiotracers for positron emission tomography (PET) have provided knowledge on the in vivo biodistribution of ARs in the central nervous system (CNS), which is of therapeutic interest for various neuropsychiatric disorders. Additio
Contemporary development in sequential Knoevenagel, Michael addition multicomponent reaction for the synthesis of 4-Aryl-5-oxo-5H-indeno[1,2-b]pyridine-3-carbonitrile
Patravale, Ajinkya A.,Gore, Anil H.,Patil, Dipti R.,Kolekar, Govind B.,Deshmukh, Madhukar B.,Choudhari, Prafulla B.,Bhatia, Manish S.,Anbhule, Prashant V.
, p. 2919 - 2935 (2016/04/05)
An uncatalyzed efficient synthesis of bioactive pyridine derivatives has been investigated for the first time by a three-component sequential multicomponent reaction tackled with aromatic aldehydes, malononitrile, and 1,3-indandione via Knoevenagel condensation followed by Michael addition. The difference between the domino multicomponent and sequential multicomponent reaction is emphasized by this methodology. The reaction proceeds at ambient temperature without frequently useful N-source like ammonium salt for the construction of N-heterocycles, which makes this protocol a novel synthetic route for the preparation of the indenopyridine skeleton.