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2978-58-7

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2978-58-7 Usage

Chemical Properties

Clear colorless to yellow liquid

Uses

1,1-Dimethylpropargylamine is used as an organic chemical synthesis intermediate.

Purification Methods

Dissolve the amine in Et2O, dry over anhydrous K2CO3, filter, evaporate and distil (preferably under N2). Store it away from CO2. The hydrochloride [2978-59-8] has m 234o (from EtOH/Et2O). The benzoyl derivative has m 152-153o (from EtOH). [Hennion & Teach J Am Chem Soc 75 1653 1953, Hennion & DiGiovanna J Org Chem 30 2645 1965.]

Check Digit Verification of cas no

The CAS Registry Mumber 2978-58-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,9,7 and 8 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 2978-58:
(6*2)+(5*9)+(4*7)+(3*8)+(2*5)+(1*8)=127
127 % 10 = 7
So 2978-58-7 is a valid CAS Registry Number.
InChI:InChI=1/C5H9N/c1-4-5(2,3)6/h1H,6H2,2-3H3

2978-58-7 Well-known Company Product Price

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  • (Code)Product description
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  • Alfa Aesar

  • (H53448)  1,1-Dimethylpropargylamine, 95%   

  • 2978-58-7

  • 5g

  • 880.0CNY

  • Detail
  • Alfa Aesar

  • (H53448)  1,1-Dimethylpropargylamine, 95%   

  • 2978-58-7

  • 25g

  • 3520.0CNY

  • Detail
  • Aldrich

  • (687189)  2-Methyl-3-butyn-2-amine  95%

  • 2978-58-7

  • 687189-5G

  • 733.59CNY

  • Detail

2978-58-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-methylbut-3-yn-2-amine

1.2 Other means of identification

Product number -
Other names 3-amini-3-methyl-1-butyne

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2978-58-7 SDS

2978-58-7Relevant articles and documents

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Engel,P.S.,Bishop,D.J.

, p. 6754 - 6762 (1975)

-

Preparation method for propyzamide

-

, (2018/05/01)

The invention discloses a preparation method for propyzamide. The preparation method comprises the following steps: preparing 3-chloro-3-methylbutyne through a chlorination reaction; then preparing 3-amino-3-methylbutyne through an aminolysis reaction; and then carrying out an amidation reaction so as to prepare high-purity propyzamide. The optimal preparation method for propyzamide is screened out through a large number of experiments; the preparation method is reasonable in the whole process design and simple and efficient in process operation; in particular, optimal reaction conditions arescreened out, optimal raw material composition is determined for the chlorination reaction in the step 1, the aminolysis reaction in the step 2 and the amidation reaction in the step 3, and the proportions of reaction raw materials, reaction temperature, reaction time and the like are optimized, so reaction yield can be greatly increased (wherein the yield can reach 93% or more), side reactions can be reduced, reaction rate can be increased, and production cost can be greatly lowered; so the preparation method has good application prospects.

Cu(I)-catalyzed synthesis of dihydropyrimidin-4-ones toward the preparation of β- And β3-amino acid analogues

Rajagopal, Basker,Chen, Ying-Yu,Chen, Chun-Chi,Liu, Xuan-Yu,Wang, Huei-Ren,Lin, Po-Chiao

supporting information, p. 1254 - 1264 (2014/03/21)

A copper(I)-catalyzed synthesis of substituted dihydropyrimidin-4-ones from propargyl amides via the formation of ketenimine intermediate has been successfully developed; the synthesis afforded good isolated yields (80-95%). The mild reaction conditions at room temperature allow the reaction to proceed to completion in a few hours without altering the stereochemistry. Further, by involving a variety of reactive nucleophiles, the obtained substituted dihydropyrimidin-4-ones were elegantly transformed into the corresponding β- and β3-amino acid analogues.

Preparation of a Series of Highly Hindered Secondary Amines, Including Bis(triethylcarbinyl)amine

Kopka, Ihor E.,Fataftah, Zacharia A.,Rathke, Michael W.

, p. 4616 - 4622 (2007/10/02)

A series of highly branched secondary amines was prepared by coupling propargylamines with propargyl chlorides.Hydrogenation of the resultant dipropargylamines was accomplished with Raney nickel in the presence of potassium hydroxide.The resultant amines, including bis(triethylcarbinyl)amine, are among the most hindered secondary amines reported to date.The pKa values of the conjugate acids of the series of secondary amines exhibit a regular decrease with increasing size of the amine.The bulkier members of the series are inert to methyl iodide.Bis(triethylcarbinyl)amine reacts with boron trifluoride etherate to give a primary amine adduct and 3-ethyl-2-pentene.

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