299928-38-4

Basic information

• Product Name: N-acetyl (2,4-dimethyl phenyl)-glycine
• CAS NO: 299928-38-4
• Molecular Weight: 221.256
• Mol File: 299928-38-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-acetyl (2,4-dimethyl phenyl)-glycine(CAS DataBase Reference)
• NIST Chemistry Reference: N-acetyl (2,4-dimethyl phenyl)-glycine(299928-38-4)
• EPA Substance Registry System: N-acetyl (2,4-dimethyl phenyl)-glycine(299928-38-4)

Safety Data

• Hazardous Substances Data: 299928-38-4(Hazardous Substances Data)

Upstream product

• 66947-32-8 N-(2,4-dimethylphenyl)glycine 
• 108-24-7 acetic anhydride 
• 95-68-1 2,4-Xylidine 

Relevant articles and documents

Identification of a Water-Soluble Indirubin Derivative as Potent Inhibitor of Insulin-like Growth Factor 1 Receptor through Structural Modification of the Parent Natural Molecule

Indirubins have been identified as potent ATP-competitive protein kinase inhibitors. Structural modifications in the 5-and 3′-position have been extensively investigated, but the impact of substituents in 5′-position is not equally well-studied. Here, we report the synthesis of new indirubin 3′-and 5′-derivatives in the search of water-soluble indirubins by introducing basic centers. Antiproliferative activity of all compounds in tumor cells was evaluated along with kinase inhibition of selected compounds. The results show the 3′-position to tolerate large substituents without compromising activity, whereas bulk and rigid substituents in 5′-position appear unfavorable. Screening molecular targets of water-soluble 3′-oxime ethers revealed 6ha as preferential inhibitor of insulin-like growth factor 1 receptor (IGF-1R) in a panel of 22 protein kinases and in cells. Consistently, 6ha inhibited tumor cell growth in the NCI 60 cell line panel and induced apoptosis. The results indicate that the 5′-position provides limited space for chemical modifications and identify 6ha as a potent water-soluble indirubin-based IGF-1R inhibitor.