299964-43-5

Basic information

• Product Name: (1R)-3-[3-amino-4-(benzyloxy)phenyl]-2-{[(2R)-1-(4-methoxyphenyl)propan-2-yl]amino}ethan-1-ol
• CAS NO: 299964-43-5
• Molecular Weight: 406.525
• Mol File: 299964-43-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1R)-3-[3-amino-4-(benzyloxy)phenyl]-2-{[(2R)-1-(4-methoxyphenyl)propan-2-yl]amino}ethan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (1R)-3-[3-amino-4-(benzyloxy)phenyl]-2-{[(2R)-1-(4-methoxyphenyl)propan-2-yl]amino}ethan-1-ol(299964-43-5)
• EPA Substance Registry System: (1R)-3-[3-amino-4-(benzyloxy)phenyl]-2-{[(2R)-1-(4-methoxyphenyl)propan-2-yl]amino}ethan-1-ol(299964-43-5)

Safety Data

• Hazardous Substances Data: 299964-43-5(Hazardous Substances Data)

Usage

General Description

The chemical "(1R)-3-[3-amino-4-(benzyloxy)phenyl]-2-{[(2R)-1-(4-methoxyphenyl)propan-2-yl]amino}ethan-1-ol" is a complex organic compound with a molecular formula of C27H33N3O3. It consists of a chiral center and contains functional groups such as an amine, phenol, and ether. The compound is a potential drug candidate as it exhibits properties that can interact with biological systems and potentially be used for therapeutic purposes. However, further research and testing are required to fully understand and utilize the chemical's properties and potential applications.

Upstream product

• 299964-37-7 Acetic acid (S)-1-(4-benzyloxy-3-nitro-phenyl)-2-bromo-ethyl ester 
• 86073-42-9 (R)-N-[1-(o-methoxyphenyl)propan-2-yl]ethanamide 
• 188690-82-6 (R)-2-bromo-1-(4-benzyloxy-3-nitrophenyl)ethanol 
• 188730-94-1 (R)-1-(4-benzyloxy-3-nitrophenyl)oxirane 
• 299964-35-5 (+/-)-2-bromo-1-(4-benzyloxy-3-nitrophenyl)ethanol 
• 123-11-5 4-methoxy-benzaldehyde 
• 58993-79-6 (R)-(-)-p-methoxyamphetamine 
• 43229-01-2 4-benzyloxy-3-nitrophenacyl bromide 
• 14347-05-8 4-benzyloxy-3-nitroacetophenone 
• 37629-51-9 1-methoxy-4-((E)-2-nitroprop-1-enyl)benzene 
• 64-13-1 2-amino-1-(4-methyoxyphenyl)propane 
• 245759-61-9 (R)-1-(4-Benzyloxy-3-nitro-phenyl)-2-[(R)-2-(4-methoxy-phenyl)-1-methyl-ethylamino]-ethanol 

Downstream Products

• 73573-87-2 (R,R)-formoterol 
• 408497-91-6 N-(2-Benzyloxy-5-{(R)-1-hydroxy-2-[(R)-2-(4-methoxy-phenyl)-1-methyl-ethylamino]-ethyl}-phenyl)-formamide 

Relevant articles and documents

An efficient enantioselective synthesis of (R,R)-formoterol, a potent bronchodilator, using lipases

The potent β2-adrenergic receptor agonist formoterol (R,R)-1 has been obtained in enantiomerically pure form by a convenient chemoenzymatic approach by coupling of epoxide (R)-6 with the unprotected primary amine (R)-9. Both chiral precursors have been prepared by enantiodifferentiation processes involving Pseudomonas cepacia (lipase PS) and Candida antarctica lipase (CALB), respectively. For the resolution of amine 9, we have found that utilization of triethylamine as non-reactive base enhances the reaction rate and the enantioselectivity of the process. The key coupling reaction of (R)-6 and (R)-9 has been conducted through derivatization of the amine with the labile trimethylsilyl group, which liberates the amino group of the resulting amino alcohol (R,R)-11 upon column chromatography purification. In this way, the overall approach is shorter than others previously described. Copyright (C) 2000 Elsevier Science Ltd.