300831-04-3Relevant articles and documents
Practical synthesis of 2-(2-isopropylaminothiazol-4-yl)-7-methoxy-1H- quinolin-4-one: Key intermediate for the synthesis of potent HCV NS3 protease inhibitor BILN 2061
Frutos, Rogelio P.,Haddad, Nizar,Houpis, Ioannis N.,Johnson, Michael,Smith-Keenan, Lana L.,Fuchs, Victor,Yee, Nathan K.,Farina, Vittorio,Faucher, Anne-Marie,Brochu, Christian,Hache, Bruno,Duceppe, Jean-Simon,Beaulieu, Pierre
, p. 2563 - 2567 (2006)
Herein we describe the development of an efficient, safe and practical process for the synthesis of 7-methoxy-2-(2-amino-4-thiazolyl)quinoline. Our new process allowed for a more convergent approach and eliminates the use of potentially dangerous reagents such as diazomethane used in the previous discovery approach. Georg Thieme Verlag Stuttgart.
HCV NS-3 serine protease inhibitors
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, (2008/06/13)
HCV inhibitors, compositions comprising these compounds as active ingredient, as well as processes for preparing these compounds, of formula: wherein A is
HCV NS-3 SERINE PROTEASE INHIBITORS
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Page/Page column 119, (2008/06/13)
Peptidomimetic compounds are described which inhibit the NS3 protease of the hepatitis C virus (HCV). The compounds have the formula where the variable definitions are as provided in the specification. The compounds comprise a carbocyclic P2 unit in conjunction with a novel linkage to those portions of the inhibitor more distal to the nominal cleavage site of the native substrate, which linkage reverses the orientation of peptidic bonds on the distal side relative to those proximal to the cleavage site.
