30093-99-3Relevant articles and documents
Retro-Ene Reactions in Heterocyclic Synthesis. III. A New Route to 4,5-Dihydrooxazoles and 5,6-Dihydro-4H-1,3-oxazines
Ito, Kunio,Miyajima, Shingo
, p. 501 - 503 (1997)
Methyl (E)-4,4-dimethyl-5-oxo-2-pentenoate (1, X = O) reacted with 1,2- or 1,3-aminoalcohols 3 to yield oxazolidines 4a-c or tetrahydro-1,3-oxazines 4d,e. The corresponding imino ester 1 (X = NBu-t) also gave 4 on reaction with 3. Compounds 4 on heating at 230° yielded 4,5-dihydrooxazoles 5a-c or 5,6-dihydro-4H-1,3-oxazines 5d,e along with methyl 4-methyl-3-pentenoale (6).
SYNTHESIS OF ISOTHIOCYANATES FROM NON-AROMATIC NITROGEN-CONTAINING HETEROCYCLES
Gonda, Jozef,Kristian, Pavol,Mikler, Lubomir
, p. 112 - 117 (2007/10/02)
Investigation of the reaction of thiophosgene with Δ2-oxazolines I, Δ3-thiazolines II, 4H-benzothiazines III, 2-methoxypentahydro-Δ1-azepine IV, theophylline and caffeine showed that only compounds I and IV reacted to give 2-acyloxyethyl isothiocyanates and methyl 6-isothiocyanatohexanoate.The structure of these products was corroborated by IR, 1H NMR, 13C NMR and mass spectral methods.The suitability of the above-mentioned compounds to react is discussed.