30148-21-1

Basic information

• Product Name: ETHYL 1-METHYL-1H-IMIDAZOLE-2-CARBOXYLATE
• Synonyms: ETHYL 1-METHYLIMIDAZOLE-2-CARBOXYLATE;ETHYL 1-METHYL-1H-IMIDAZOLE-2-CARBOXYLATE;RARECHEM AL BI 0638;Ethyl 1-methyl-1H-imidazole-2-carboxylate ,97%;1-Methyl-1H-iMidazole-2-carboxylic Acid Ethyl Ester;RGW 811;2-(Ethoxycarbonyl)-1-methyl-1H-imidazole;1--1H--2-MethyliMidazoleethyl forMate
• CAS NO: 30148-21-1
• Molecular Formula: C₇H₁₀N₂O₂
• Molecular Weight: 154.17
• Product Categories: Miscellaneous Reagents
• Mol File: 30148-21-1.mol
• Article Data: 19

Chemical Properties

• Melting Point: 29-31°C
• Boiling Point: 110-111°C/ 0.5 mmHg
• Flash Point: 107.9 °C
• Appearance: /Solid
• Density: 1.14 g/cm³
• Vapor Pressure: 0.0169mmHg at 25°C
• Refractive Index: 1.525
• Storage Temp.: 2-8°C
• Solubility: Soluble in dichloromethane, ether, ethyl acetate and methanol.
• PKA: 4.00±0.25(Predicted)
• CAS DataBase Reference: ETHYL 1-METHYL-1H-IMIDAZOLE-2-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 1-METHYL-1H-IMIDAZOLE-2-CARBOXYLATE(30148-21-1)
• EPA Substance Registry System: ETHYL 1-METHYL-1H-IMIDAZOLE-2-CARBOXYLATE(30148-21-1)

Safety Data

• Hazard Codes: T
• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 30148-21-1(Hazardous Substances Data)

Usage

Chemical Properties

White Crystalline Solid

Uses

Different sources of media describe the Uses of 30148-21-1 differently. You can refer to the following data:
1. Ethyl 1-methyl-1H-imidazole-2-carboxylate is a useful synthetic intermediate for solid phase synthesis of polyamides containing imidazole.
2. Ethyl 1-methylimidazole-2-carboxylate is used as a synthetic intermediate for solid phase synthesis of polyamides containing imidazole.

InChI:InChI=1/C7H10N2O2/c1-3-11-7(10)6-8-4-5-9(6)2/h4-5H,3H2,1-2H3

Upstream product

• 33543-78-1 ethyl 1H-imidazole-2-carboxylate 
• 74-88-4 methyl iodide 
• 616-47-7 1-methyl-1H-imidazole 
• 109-94-4 formic acid ethyl ester 
• 541-41-3 chloroformic acid ethyl ester 
• 35342-89-3 1-methyl-2-(trimethylsilyl)-1H-imidazole 

Downstream Products

• 616-47-7 1-methyl-1H-imidazole 
• 17334-08-6 1-methyl-2-hydroxymethylimidazole 
• 33543-79-2 1-methyl-1H-imidazole-2-carboxylic acid hydrazide 
• 62366-40-9 bis(N-methylimidazol-2-yl)ketone 
• 111931-14-7 Dicyclohexyl-(1-methyl-1H-imidazol-2-yl)-methanol 
• 111931-15-8 3-(1-Methyl-1H-imidazol-2-yl)-1,5-diphenyl-pentan-3-ol 
• 111931-16-9 3-(1-Methyl-1H-imidazol-2-yl)-1,5-diphenyl-penta-1,4-diyn-3-ol 
• 20062-51-5 1-methyl-1H-imidazole-2-carboxamide 
• 109012-23-9 ethyl 1-methyl-4-nitroimidazole-2-carboxylate 
• 109012-22-8 ethyl 1-methyl-4,5-dinitroimidazole-2-carboxylate 
• 1564-49-4 ethyl 1-methyl-5-nitro-1H-imidazole-2-carboxylate 
• 1229426-30-5 ethyl 3-(1-methyl-1H-imidazol-2-yl)-3-oxopropanoate 
• 1260672-33-0 ethyl 4-bromo-1-methyl-1H-imidazole-2-carboxylate 
• 1441045-97-1 (S)-[2-(methoxydiphenylmethyl)pyrrolidin-1-yl](1-methyl-1H-imidazol-2-yl)methanone 

Relevant articles and documents

CYCLIC AMINE DERIVATIVE AS AGENT FOR PROMOTING ADVILLIN FUNCTION, AND NOVEL CYCLIC AMINE DERIVATIVE AND PHARMACEUTICAL USE THEREOF

An object of the present invention is to provide an agent for promoting advillin function that comprises a low molecular weight compound, and is useful for treatment of axonal injury. The present invention provides an agent for promoting advillin function, comprising a cyclic amine derivative typically represented by the following chemical formula, or a pharmacologically acceptable salt thereof as an active ingredient.

Photocatalytic acyl azolium-promoted alkoxycarbonylation of trifluoroborates

Despite recent advancements in the selective generation and coupling of organic radical species, the alkoxycarbonyl radical remains underexplored relative to other carbon-containing radical species. Drawing inspiration from new strategies for generating acyl radical equivalents utilizing dual N-heterocyclic carbene catalysis and photocatalysis, we have prepared dimethylimidazolium esters that can function as an alkoxycarbonyl radical surrogate under photocatalytic conditions. We demonstrate the synthetic utility of these azolium-based partners through the preparation of esters arising from the coupling of this radical surrogate with an oxidatively generated alkyl radical.

Application of 1-substituted-1H-imidazole-2-carboxylic acid compounds in preparation of metal beta-lactamase inhibitors

The invention relates to application of 1-substituted-1H-imidazole-2-carboxylic acid compounds in preparation of metal beta-lactamase inhibitors, and particularly discloses application of compounds shown in a formula I in preparation of metal beta-lactamase inhibitors or antibacterial combined medicines. Experiments prove that the compounds provided by the invention can be used for effectively inhibiting the activity of various MBL enzymes including VIM-2, NDM-1, IMP-1, VIM-1 and VIM-5; the compounds, especially the compounds 11, 13, 14, 29, 30, 34, 37 and 40, have an IC50 value of 2.13 [mu] Mor less on the VIM-2 type MBL enzymes, have a more significant inhibition effect than positive control drugs, and have very good potential in the preparation of MBL enzyme inhibitors. Meanwhile, thecompounds disclosed by the invention are combined with beta-lactam antibiotics, so that metal beta-lactamase generated by drug-resistant bacteria can be effectively inhibited, the antibacterial activity of the antibiotics is enhanced, and the compounds have a very good application prospect in preparation of antibacterial combined medicines.