3024-72-4

Basic information

• Product Name: 3,4-Dichlorobenzoyl chloride
• Synonyms: 3,4-dichloro-benzoylchlorid;3,4-DICHLOROBENZOYL CHLORIDE;3,4-DCOC;Benzoyl chloride, 3,4-dichloro- (6CI,7CI,8CI,9CI);3,4-Dichlorobenzoyl;Benzoyl chloride, 3,4-dichloro-;3,4-DICHLOROBENZOYL CHLORIDE 95+%;3, 4-Dichlorobenzoil chloride
• CAS NO: 3024-72-4
• Molecular Formula: C₇H₃Cl₃O
• Molecular Weight: 209.46
• EINECS: 221-177-2
• Product Categories: ACIDHALIDE;Organics;API intermediates;Acid Halides;Carbonyl Compounds;Organic Building Blocks;Acid Halides;Building Blocks;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks
• Mol File: 3024-72-4.mol
• Article Data: 38

Chemical Properties

• Melting Point: 30-33 °C(lit.)
• Boiling Point: 242 °C(lit.)
• Flash Point: 288 °F
• Appearance: White to yellow/Crystalline Low Melting Solid
• Density: 1.5078 (estimate)
• Vapor Pressure: 0.00223mmHg at 25°C
• Refractive Index: 1.566
• Sensitive: Moisture Sensitive
• BRN: 607485
• CAS DataBase Reference: 3,4-Dichlorobenzoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-Dichlorobenzoyl chloride(3024-72-4)
• EPA Substance Registry System: 3,4-Dichlorobenzoyl chloride(3024-72-4)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-27-28-36/37/39-45
• RIDADR: UN 3261 8/PG 2
• WGK Germany: 3
• F: 10-21-19
• TSCA: Yes
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 3024-72-4(Hazardous Substances Data)

Usage

Chemical Properties

white to yellowish crystalline low melting solid

General Description

3,4-Dichlorobenzoyl chloride was used in the synthesis of 3,4-dichlorophenylacetic acid by Arndt-Eistert method. It is prepared by refluxing 3,4-dichlorobenzoic acid with thionyl chloride.

InChI:InChI=1/C8H5Cl3O/c9-6-2-1-5(3-7(6)10)4-8(11)12/h1-3H,4H2

Upstream product

• 51-44-5 3,4-dichlorbenzoic acid 
• 13014-24-9 3,4-dichloro-1-trichloromethylbenzene 

Downstream Products

• 35455-59-5 5,3',4'-trichloro-2-hydroxy-benzophenone 
• 7506-97-0 3,4-dichloro-N,N-diethylbenzamide 
• 34333-43-2 4-(3,4-dichloro-benzoyl)-2,6-dimethyl-morpholine 
• 141362-96-1 N-(3,4-Dichlorobenzoyl)-2,2-dimethylaziridine 
• 93669-42-2 3,4-Dichloro-N-(2-imidazol-1-yl-ethyl)-benzamide 
• 83167-12-8 4-(3,4-Dichloro-benzoyl)-5-methyl-1,3-dihydro-imidazol-2-one 
• 155635-86-2 3,4-dichlorobenzoyl-1H-pyrrol-2-ylketone 
• 18094-90-1 3,4-dichloro-N-(2-hydroxyphenyl)benzamide 
• 2670-38-4 3,4-dichlorobenzamide 
• 7501-10-2 3,4-dichloro-benzoic acid-(2-chloro-ethyl ester) 
• 106522-45-6 N,N'-bis-(3,4-dichloro-benzoyl)-urea 
• 5452-18-6 3,4-dichloro-benzoic acid-(2-amino-4-oxo-3,4,5,6,7,8-hexahydro-quinazolin-6-ylamide) 
• 28394-59-4 3,4-dichloro-benzoic acid-(2,2,2-trichloro-ethyl ester) 
• 109554-80-5 3,4-dichloro-benzoic acid-(1-phenyl-2-pyrrolidino-ethyl ester); hydrochloride 

Relevant articles and documents

Discovery and Mechanism of Action of Small Molecule Inhibitors of Ceramidases**

Sphingolipid metabolism is tightly controlled by enzymes to regulate essential processes in human physiology. The central metabolite is ceramide, a pro-apoptotic lipid catabolized by ceramidase enzymes to produce pro-proliferative sphingosine-1-phosphate. Alkaline ceramidases are transmembrane enzymes that recently attracted attention for drug development in fatty liver diseases. However, due to their hydrophobic nature, no specific small molecule inhibitors have been reported. We present the discovery and mechanism of action of the first drug-like inhibitors of alkaline ceramidase 3 (ACER3). In particular, we chemically engineered novel fluorescent ceramide substrates enabling screening of large compound libraries and characterized enzyme:inhibitor interactions using mass spectrometry and MD simulations. In addition to revealing a new paradigm for inhibition of lipid metabolising enzymes with non-lipidic small molecules, our data lay the ground for targeting ACER3 in drug discovery efforts.

Benzoyl-containing rupestonic acid methyl ester derivative as well as preparation method and application thereof

The invention relates to a benzoyl-containing rupestonic acid methyl ester derivative as well as a preparation method and application thereof. Rupestonic acid and dimethyl sulfate react to obtain rupestonic acid methyl ester, 2-hydroxyl rupestonic acid methyl ester is prepared under oxidation of camphor sulfonyl acridine, and then the 2-hydroxyl rupestonic acid methyl ester reacts with different substituted benzoyl chloride under the catalysis of DMAP to obtain the 1d-15d benzoyl-containing rupestonic acid methyl ester derivative. The method has the advantages of mild reaction conditions and simple experimental steps. The obtained benzoyl-containing rupestonic acid methyl ester derivative 1d-15d is subjected to an anti-H3N2 influenza A virus activity test in 1d-15d. Experimental results show that the compounds 1d, 2d, 4d, 5d, 7d, 8d, 12d, 13d and 15d can be applied to preparation of drugs for resisting influenza A H3N2 virus.

Preparation method of benzoyl chloride compound

The invention provides a preparation method of a benzoyl chloride compound. The preparation method comprises the following step: with a trichloromethyl benzene compound and a benzoic acid compound as raw materials and ferric oxide as a catalyst, carrying out a catalytic reaction to prepare the benzoyl chloride compound. According to the method disclosed by the invention, the benzoyl chloride compound can be obtained under the condition of not using a solvent, yield is up to 95% or above, atom economy is good, cost is lower, operation is simpler, more convenient and safer, the treatment amount of three wastes is smaller, the three wastes is easier to treat, and the method is more suitable for industrial production.