303-48-0

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Basic information

Product Name: N-DESMETHYLCLOMIPRAMINE HYDROCHLORIDE
Synonyms: NORCLOMIPRAMINE HYDROCHLORIDE;desmethylclomipramine;5H-Dibenzb,fazepine-5-propanamine, 3-chloro-10,11-dihydro-N-methyl-;n-desmethylclomipramine;N-DESMETHYLCLOMIPRAMINE,1.0MG/MLINMETHANOL;3-Chloro-10,11-dihydro-N-methyl-5H-dibenz[b,f]azepine-5-propanamine Hydrochloride;Chlordesipramine Hydrochloride;Demethylchlorimipramine Hydrochloride
CAS NO:303-48-0
Molecular Formula: C18H22Cl2N2
Molecular Weight: 337.29
EINECS: N/A
Product Categories: Heterocyclic Compounds;Various Metabolites and Impurities;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
Mol File: 303-48-0.mol
Article Data: 2

Chemical Properties

Melting Point: N/A
Boiling Point: 439.5°Cat760mmHg
Flash Point: 219.6°C
Appearance: white/powder
Density: 1.129g/cm³
Vapor Pressure: 6.34E-08mmHg at 25°C
Refractive Index: 1.583
Storage Temp.: N/A
Solubility: N/A
PKA: 10.37±0.10(Predicted)
CAS DataBase Reference: N-DESMETHYLCLOMIPRAMINE HYDROCHLORIDE(CAS DataBase Reference)
NIST Chemistry Reference: N-DESMETHYLCLOMIPRAMINE HYDROCHLORIDE(303-48-0)
EPA Substance Registry System: N-DESMETHYLCLOMIPRAMINE HYDROCHLORIDE(303-48-0)

Safety Data

Hazard Codes: Xn
Statements: 20/21/22
Safety Statements: 36
WGK Germany: 3
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 303-48-0(Hazardous Substances Data)

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Cas No: 303-48-0
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Zhuozhou Wenxi import and Export Co., Ltd
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N-DESMETHYLCLOMIPRAMINE HYDROCHLORIDE
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Hangzhou Keyingchem Co.,Ltd
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N-DESMETHYLCLOMIPRAMINE HYDROCHLORIDE
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Henan Allgreen Chemical Co.,Ltd
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N-DESMETHYLCLOMIPRAMINE HYDROCHLORIDE
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Henan Tianfu Chemical Co., Ltd.
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N-DESMETHYLCLOMIPRAMINE HYDROCHLORIDE
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Shanghai Yuanye Bio-Technology Co., Ltd.
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N-DESMETHYLCLOMIPRAMINE HYDROCHLORIDE
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ZHEJIANG JIUZHOU CHEM CO.,LTD
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5H-Dibenz[b,f]azepine-5-propanamine,3-chloro-10,11-dihydro-N-methyl-
Cas No: 303-48-0
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Shanghai united Scientific Co.,Ltd.
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[2H6]-N-Desmethylclomipramine
Cas No: 303-48-0
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SHANGHAI ZZBIO CO., LTD.
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5H-Dibenz[b,f]azepine-5-propanamine,3-chloro-10,11-dihydro-N-methyl-
Cas No: 303-48-0
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Chemical Co.Ltd
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Norclomipramine hydrochloride
Cas No: 303-48-0
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Sigma-Aldrich Chemie GmbH
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303-48-0 Usage

Uses

A metabolite of Clomipramine

Biochem/physiol Actions

Tricyclic antidepressant; an active metabolite of clomipramine that preferentially blocks the norepinephrine transporter.

Check Digit Verification of cas no

The CAS Registry Mumber 303-48-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,0 and 3 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 303-48:
(5*3)+(4*0)+(3*3)+(2*4)+(1*8)=40
40 % 10 = 0
So 303-48-0 is a valid CAS Registry Number.

InChI:InChI=1/C18H21ClN2/c1-20-11-4-12-21-17-6-3-2-5-14(17)7-8-15-9-10-16(19)13-18(15)21/h2-3,5-6,9-10,13,20H,4,7-8,11-12H2,1H3

303-48-0 Well-known Company Product Price

Brand
(Code)Product description
CAS number
Packaging
Price
Detail

Aldrich
(N1280) Norclomipraminehydrochloride ~99% (TLC), powder
303-48-0
N1280-10MG
1,427.40CNY
Detail

Aldrich
(N1280) Norclomipraminehydrochloride ~99% (TLC), powder
303-48-0
N1280-25MG
2,861.82CNY
Detail

303-48-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name	N-DESMETHYLCLOMIPRAMINE HYDROCHLORIDE

1.2 Other means of identification

Product number	-
Other names	Demethylchlorimipramine

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:303-48-0 SDS

303-48-0Upstream product

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303-48-0Relevant articles and documents

HECT E3 LIGASE INHIBITORS AND USES THEREOF

-

Page/Page column 47, (2020/12/29)

The present invention relates to tricyclic derivatives of formula (I), which are useful as inhibitors of HECT-domain-containing E3 ligases, in particular NEDD4. The present invention also refers to pharmaceutical compositions comprising compounds of formu

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