303-48-0 Usage
Uses
A metabolite of Clomipramine
Biochem/physiol Actions
Tricyclic antidepressant; an active metabolite of clomipramine that preferentially blocks the norepinephrine transporter.
Check Digit Verification of cas no
The CAS Registry Mumber 303-48-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,0 and 3 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 303-48:
(5*3)+(4*0)+(3*3)+(2*4)+(1*8)=40
40 % 10 = 0
So 303-48-0 is a valid CAS Registry Number.
InChI:InChI=1/C18H21ClN2/c1-20-11-4-12-21-17-6-3-2-5-14(17)7-8-15-9-10-16(19)13-18(15)21/h2-3,5-6,9-10,13,20H,4,7-8,11-12H2,1H3
303-48-0Relevant articles and documents
HECT E3 LIGASE INHIBITORS AND USES THEREOF
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Page/Page column 47, (2020/12/29)
The present invention relates to tricyclic derivatives of formula (I), which are useful as inhibitors of HECT-domain-containing E3 ligases, in particular NEDD4. The present invention also refers to pharmaceutical compositions comprising compounds of formu