303-54-8

Basic information

• Product Name: Depramine
• Synonyms: Depramine;5-[3-(Dimethylamino)propyl]-5H-dibenz[b,f]azepine;5-[3-(Dimethylamino)propyl-5H-dibenz[b,f]azepine;Balipramine;Dehydroimipramine;GP31406;3-benzo[b][1]benzazepin-11-yl-N,N-dimethylpropan-1-amine
• CAS NO: 303-54-8
• Molecular Formula: C19H22 N2
• Molecular Weight: 278.43
• Mol File: 303-54-8.mol
• Article Data: 3

Chemical Properties

• Melting Point: 56-57 °C(Solv: pentane (109-66-0))
• Boiling Point: 411.21°C (rough estimate)
• Flash Point: 185.9°C
• Appearance: /
• Density: 0.9702 (rough estimate)
• Vapor Pressure: 4.64E-07mmHg at 25°C
• Refractive Index: 1.8676 (estimate)
• PKA: 9.47±0.28(Predicted)
• CAS DataBase Reference: Depramine(CAS DataBase Reference)
• NIST Chemistry Reference: Depramine(303-54-8)
• EPA Substance Registry System: Depramine(303-54-8)

Safety Data

• Hazardous Substances Data: 303-54-8(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 303-54-8 differently. You can refer to the following data:
1. [Name previously used: Balipramine.
2. Depramine is an antidepressant.

InChI:InChI=1/C19H22N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-13H,7,14-15H2,1-2H3

Upstream product

• 50-00-0 formaldehyd 
• 2064-34-8 3-(5H-dibenzo[b,f]azepin-5-yl)propan-1-amine 
• 256-96-2 dibenzoazepine 
• 109-54-6 3-(Dimethylamino)propyl chloride 

Relevant articles and documents

Determination of imipramine in plasma by high pressure liquid chromatography and field ionization mass spectrometry: Increased sensitivity in comparison with gas chromatography mass spectrometry

A quantitative method is reported for the determination of imipramine in plasma samples in the low nanogram and subnanogram range. The sensitivity and precision of the technique, which involves high pressure liquid chromatography and direct probe field ionization mass spectrometry, are approximately an order of magnitude greater than are offered by gas chromatography mass spectrometry with selected ion monitoring using deuterated or other types of internal standards. [3H6] Imipramine, labeled in the ethylene bridge and in the aromatic rings, serves as the isotopic diluent. The method has been used for the determination of the comparative bioavailabilities of two different commercial preparations of imipramine. In these tests, subjects ingested a 25 mg tablet of one or the other drug preparation together with a solution containing an equivalent amount of imipramine deuterated in the ethylene bridge ([2H2]imipramine). The latter served as an internal check for intrasubject variability in absorption of the imipramine tablets. Typical results from one of the subjects are presented.

N-Dimethylaminopropylation in a solid-liquid two phase system: Synthesis of chlorpromazine, its analogs, and related compounds

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