304-47-2Relevant articles and documents
Bioinspired Syntheses of the Pyridoacridine Marine Alkaloids Demethyldeoxyamphimedine, Deoxyamphimedine, and Amphimedine
Khalil, Iman M.,Barker, David,Copp, Brent R.
, p. 282 - 289 (2016/01/15)
Efficient bioinspired syntheses of the biologically active pyridoacridine marine alkaloids demethyldeoxyamphimedine, deoxyamphimedine, and amphimedine are reported. Reaction of styelsamine D, prepared via an optimized route starting from Boc-dopamine, wit
Synthesis, DNA binding and antitumor evaluation of styelsamine and cystodytin analogues
Fong, Hugo K.H.,Copp, Brent R.
, p. 274 - 299 (2013/05/21)
A series of N-14 sidechain substituted analogues of styelsamine (pyrido[4,3,2-mn]acridine) and cystodytin (pyrido[4,3,2-mn]acridin-4-one) alkaloids have been prepared and evaluated for their DNA binding affinity and antiproliferative activity towards a pa
A simple biomimetic synthesis of styelsamine B.
Skyler,Heathcock
, p. 4323 - 4324 (2007/10/03)
An extremely rapid, low cost, and environmentally friendly entry into the pyridoacridine family of alkaloids has been devised, as demonstrated here by the first total synthesis of styelsamine B (3) and its oxidation to the quinoneimine cystodytin J (4). T