30544-47-9 Usage
Chemical Properties
Light Yellow Oil
Originator
Rheumon,Troponwerke,W. Germany,1977
Uses
Different sources of media describe the Uses of 30544-47-9 differently. You can refer to the following data:
1. Medication used to alleviate joint and muscle pain.
2. anti-inflammatory;cyclooxygenase inhibitor
3. As a histamine H1 -receptor antagonist, Etofenamate can be used as anti-inflammatory;cyclooxygenase inhibitor and medication used to alleviate joint and muscle pain.
Manufacturing Process
16.0 g (0.05 mol) of the potassium salt of N-(3-trifluoromethylphenyl)-
anthranilic acid are dissolved in 60 ml of dimethylformamide and heated to
110°C, and 6.2 g (0.05 mol) of 2-(2-chloroethoxy)-ethanol are slowly added.
The reaction mixture is then heated to boiling for 2 hours. The precipitated
potassium chloride is filtered off and the solvent is removed by evaporation.
The residue is separated over a column with 400 g of silica gel (particle size
0.05 to 0.2 mm), using a 1:1 mixture of cyclohexane and glacial acetic acid
as eluting agent. 16.0 g of the 2-(2-hydroxyethoxy)-ethyl ester of N-(3-
trifluoromethylphenyl)-anthranilic acid are obtained in the form of a pale
yellow oil which does not crystallize and cannot be distilled.
Therapeutic Function
Antiinflammatory
Check Digit Verification of cas no
The CAS Registry Mumber 30544-47-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,0,5,4 and 4 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 30544-47:
(7*3)+(6*0)+(5*5)+(4*4)+(3*4)+(2*4)+(1*7)=89
89 % 10 = 9
So 30544-47-9 is a valid CAS Registry Number.
InChI:InChI=1/C18H18F3NO4/c19-18(20,21)13-4-3-5-14(12-13)22-16-7-2-1-6-15(16)17(24)26-11-10-25-9-8-23/h1-7,12,22-23H,8-11H2
30544-47-9Relevant articles and documents
Methods for use of GABAa receptor GABAergic compounds
-
, (2008/06/13)
A method is disclosed for potentiating mammalian GABA A receptor responses to GABA. The receptor responses are potentiated according to the invention by contacting GABA A receptors with GABA and an effective amount of non-steroidal anti-inflammatory agents, in particular, fenamates and structurally related compounds.
On the chemistry of etofenamate, a novel antiinflammatory agent from the series of N arylanthranilic acid derivatives
Boltze,Kreisfeld
, p. 1300 - 1312 (2007/10/08)
2-(2-hydroxyethoxy)ethyl-N-(α,α,α-trifluoro-m-toly)anthranilate (etofenamate) was selected as an antiphlogistic agent for percutaneous therapy. Its characteristic alcohol-ether-ester structure brings about an increase in lipophilia and in its ability to penetrate through the intact skin. Furthermore, its oily consistency renders it ideal for pharmaceutical formulation in gels. The physico-chemical material constants, partition coefficients (R(m) values) as a measure for lipophilia, spectra and molecular models of etofenamate are described. Various methods of synthesis of etofenamate and of its intermediates are described. Structural identification is made of by-products simultaneously obtained in the reaction. Pure etofenamate is obtained through repeated molecular distillation. The synthesis is carried out uniformly with protected reaction components and, after splitting off the protective groups, extremely pure etofenamate is obtained.
