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3055-99-0

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3055-99-0 Usage

Uses

Nonaethylene Glycol Monododecyl Ether is a nonionic surfactant useful in the formation of emulsions.

General Description

Nonaethylene glycol monododecyl ether [C12H25O(CH2CH2O)9H] (AEO9) is a non-ionic surfactant.

Check Digit Verification of cas no

The CAS Registry Mumber 3055-99-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,0,5 and 5 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 3055-99:
(6*3)+(5*0)+(4*5)+(3*5)+(2*9)+(1*9)=80
80 % 10 = 0
So 3055-99-0 is a valid CAS Registry Number.
InChI:InChI=1/C30H62O10/c1-2-3-4-5-6-7-8-9-10-11-13-32-15-17-34-19-21-36-23-25-38-27-29-40-30-28-39-26-24-37-22-20-35-18-16-33-14-12-31/h31H,2-30H2,1H3

3055-99-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name polidocanol

1.2 Other means of identification

Product number -
Other names 2-[2-[2-[2-[2-[2-[2-[2-(2-dodecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:3055-99-0 SDS

3055-99-0Synthetic route

oxirane
75-21-8

oxirane

1-dodecyl alcohol
112-53-8

1-dodecyl alcohol

polidocanol
3055-99-0

polidocanol

Conditions
ConditionsYield
With K10 clay at 50℃;94%
With potassium hydroxide at 140 - 170℃;
Hexaethylene glycol monododecyl ether
3055-96-7

Hexaethylene glycol monododecyl ether

C6H12O6S

C6H12O6S

polidocanol
3055-99-0

polidocanol

Conditions
ConditionsYield
Stage #1: Hexaethylene glycol monododecyl ether With sodium hydride In tetrahydrofuran; mineral oil for 0.5h; Inert atmosphere;
Stage #2: C6H12O6S In tetrahydrofuran; mineral oil pH=2; Inert atmosphere;
Stage #3: With sulfuric acid In tetrahydrofuran; water; mineral oil at 80℃; for 2h; Inert atmosphere;
77%
Stage #1: Hexaethylene glycol monododecyl ether With sodium hydride In tetrahydrofuran at 0 - 20℃; for 0.5h;
Stage #2: C6H12O6S In tetrahydrofuran at 20℃; for 3h;
Stage #3: With sulfuric acid In tetrahydrofuran; water at 20 - 80℃; for 2h;
77%
1-{2-[2-(2-{2-[2-(2-chloro-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-dodecane
17464-54-9

1-{2-[2-(2-{2-[2-(2-chloro-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-dodecane

2,2'-[1,2-ethanediylbis(oxy)]bisethanol
112-27-6

2,2'-[1,2-ethanediylbis(oxy)]bisethanol

polidocanol
3055-99-0

polidocanol

Conditions
ConditionsYield
With sodium
2,2'-[1,2-ethanediylbis(oxy)]bisethanol
112-27-6

2,2'-[1,2-ethanediylbis(oxy)]bisethanol

polidocanol
3055-99-0

polidocanol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: triethylamine; dmap; thionyl chloride / dichloromethane / 0 - 25 °C
2.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / Inert atmosphere
2.2: pH 2 / Inert atmosphere
2.3: 2 h / 80 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1.1: triethylamine; dmap; thionyl chloride / dichloromethane / 0 - 25 °C
2.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / Inert atmosphere
2.2: pH 2 / Inert atmosphere
2.3: 2 h / 80 °C / Inert atmosphere
3.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / Inert atmosphere
3.2: pH 2 / Inert atmosphere
3.3: 2 h / 80 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1.1: triethylamine; dmap; thionyl chloride / dichloromethane / 0 - 25 °C
2.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / Inert atmosphere
2.2: Inert atmosphere
2.3: 2 h / 80 °C / Inert atmosphere
3.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / Inert atmosphere
3.2: pH 2 / Inert atmosphere
3.3: 2 h / 80 °C / Inert atmosphere
4.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / Inert atmosphere
4.2: pH 2 / Inert atmosphere
4.3: 2 h / 80 °C / Inert atmosphere
View Scheme
C6H12O6S

C6H12O6S

polidocanol
3055-99-0

polidocanol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / Inert atmosphere
1.2: pH 2 / Inert atmosphere
1.3: 2 h / 80 °C / Inert atmosphere
2.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / Inert atmosphere
2.2: pH 2 / Inert atmosphere
2.3: 2 h / 80 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / Inert atmosphere
1.2: Inert atmosphere
1.3: 2 h / 80 °C / Inert atmosphere
2.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / Inert atmosphere
2.2: pH 2 / Inert atmosphere
2.3: 2 h / 80 °C / Inert atmosphere
3.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / Inert atmosphere
3.2: pH 2 / Inert atmosphere
3.3: 2 h / 80 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 - 20 °C
1.2: 3 h / 20 °C
1.3: 2 h / 20 °C
2.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 - 20 °C
2.2: 3 h / 20 °C
2.3: 2 h / 20 - 80 °C
3.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 - 20 °C
3.2: 3 h / 20 °C
3.3: 2 h / 20 - 80 °C
View Scheme
2-[2-(2-Dodecyloxy-ethoxy)-ethoxy]-ethanol
3055-94-5

2-[2-(2-Dodecyloxy-ethoxy)-ethoxy]-ethanol

polidocanol
3055-99-0

polidocanol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / Inert atmosphere
1.2: pH 2 / Inert atmosphere
1.3: 2 h / 80 °C / Inert atmosphere
2.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / Inert atmosphere
2.2: pH 2 / Inert atmosphere
2.3: 2 h / 80 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 - 20 °C
1.2: 3 h / 20 °C
1.3: 2 h / 20 - 80 °C
2.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 - 20 °C
2.2: 3 h / 20 °C
2.3: 2 h / 20 - 80 °C
View Scheme
polidocanol
3055-99-0

polidocanol

methyl iodide
74-88-4

methyl iodide

C31H64O10

C31H64O10

Conditions
ConditionsYield
Stage #1: polidocanol With sodium hydride In tetrahydrofuran; mineral oil for 0.5h; Inert atmosphere;
Stage #2: methyl iodide In tetrahydrofuran; mineral oil Inert atmosphere;
94%
(2,3-Dioxo-2,3-dihydro-1H-indol-1-yl)acetic acid
60705-96-6

(2,3-Dioxo-2,3-dihydro-1H-indol-1-yl)acetic acid

polidocanol
3055-99-0

polidocanol

C40H67NO13

C40H67NO13

Conditions
ConditionsYield
With sulfuric acid In toluene at 150℃; for 35h; Molecular sieve;83.12%
polidocanol
3055-99-0

polidocanol

C6H12O6S

C6H12O6S

laureth-12
3056-00-6

laureth-12

Conditions
ConditionsYield
Stage #1: polidocanol With sodium hydride In tetrahydrofuran; mineral oil for 0.5h; Inert atmosphere;
Stage #2: C6H12O6S In tetrahydrofuran; mineral oil pH=2; Inert atmosphere;
Stage #3: With sulfuric acid In tetrahydrofuran; water; mineral oil at 80℃; for 2h; Inert atmosphere;
59%
ethyl 2-hydroxypropionate
97-64-3, 2676-33-7

ethyl 2-hydroxypropionate

polidocanol
3055-99-0

polidocanol

polidocanol lactate

polidocanol lactate

Conditions
ConditionsYield
With sodium hydrogencarbonate at 62℃; under 15 Torr; for 24h; Enzymatic reaction;38.19 g
polidocanol
3055-99-0

polidocanol

C6H12O6S

C6H12O6S

C37H76O13

C37H76O13

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / Inert atmosphere
1.2: pH 2 / Inert atmosphere
1.3: 2 h / 80 °C / Inert atmosphere
2.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / Inert atmosphere
2.2: Inert atmosphere
View Scheme
polidocanol
3055-99-0

polidocanol

phenyl isocyanate
103-71-9

phenyl isocyanate

C37H67NO11

C37H67NO11

Conditions
ConditionsYield
In methanol; acetonitrile at 70℃; for 1h;
polidocanol
3055-99-0

polidocanol

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

C37H68O12S

C37H68O12S

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 50℃; for 12h;

3055-99-0Downstream Products

3055-99-0Relevant articles and documents

Nonionic Isatin Surfactants: Synthesis, Quantum Chemical Calculations, ADMET and Their Antimicrobial Activities

Hussein, Ahmed M.,Khowdiary, Manal M.

, p. 489 - 501 (2020/02/11)

The most challenge task in the building up of surface-active molecules is maximizing their surface activity with good biological activity. A nonionic surfactant (N-isatin-EOm-Cn where m is 5, 7 and 9 ethylene glycol units and n is 8, 10 and 12) is achieved by first reacting isatin with chloroacetic acid and then with different types of ethoxylated (C8–C12) fatty alcohols that possess 5, 7 and 9 ethylene oxide units. The prepared surfactants were characterized by FTIR and 1H NMR to confirm the structure. The surface activity, biodegradability, antimicrobial, and antifungal activity of the surfactants were evaluated. In addition, quantum chemical calculations and computations of oral bioavailability were performed. The obtained data show that all the synthesized compounds had good surface activity, biodegradability and biological activity.

Preparation method and application of monodisperse nonapolyethylene glycol dodecyl alcohol monoether and sulphate thereof

-

, (2017/08/27)

The invention discloses a preparation method and application of monodisperse nonapolyethylene glycol dodecyl alcohol monoether and sulphate thereof and belongs to the field of pharmaceutical and chemical industry. Starting from dodecyl alcohol, firstly ring-opening reaction is carried out with nonapolyethylene glycol cyclic sulphate once or with multiple oligomeric ethylene glycol cyclic sulphate containing nine ethylene glycol units in total for multiple times in presence of alkali, so that sulphate of nonapolyethylene glycol dodecyl alcohol monoether is obtained; and then hydrolysis is carried out in presence of sulphuric acid, so that the nonapolyethylene glycol dodecyl alcohol monoether is obtained. The preparation method can be applied to preparation of long-chain alkyl monoether of monodisperse polyethylene glycol and sulphate thereof. The preparation method disclosed by the invention has the advantages that single molecular weight polyethylene glycol cyclic sulphate is taken as a raw material, efficient synthesis of more than hexameric alkyl alcohol monoether of ethylene glycol is realized, no protecting group is used during synthesis, steps are simple and convenient, the preparation method is applicable to industrial production, and the obtained product has obvious advantages compared with existing prepared lauromacrogol.

PHOSPHOLIPID-DETERGENT CONJUGATES AND USES THEREOF

-

Page/Page column 79; 80, (2013/03/26)

The invention relates to novel compounds, in particular novel O-substituted phospholipids that are useful for the in vitro and in vivo delivery of drugs as well as nucleic acids into cells. The invention also relates to pharmaceutical compositions and supramolecular complexes comprising said compounds and the use of these compounds in therapeutic treatment, in particular in gene therapy.

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