30608-62-9

Basic information

• Product Name: (S)-(-)-1,2-Epoxybutane
• Synonyms: (S)-(-)-1,2-EPOXYBUTANE;(S)-1,2-EPOXYBUTANE;2S-ETHYLOXIRANE;(S)-1-Butene oxide;(S)-Ethyloxirane;(S)-()-1,2-Epoxybutane,(2S)-Ethyloxirane;(S)-1,2-Butylene oxide;(2S)-(-)-1,2-Epoxybutane, (2S)-(-)-3-Methyl-1,2-propenoxide
• CAS NO: 30608-62-9
• Molecular Formula: C₄H₈O
• Molecular Weight: 72.11
• Product Categories: Chiral Compounds;Epoxides
• Mol File: 30608-62-9.mol
• Article Data: 29

Chemical Properties

• Boiling Point: 63 °C(lit.)
• Flash Point: 10 °F
• Appearance: /
• Density: 0.837 g/mL at 25 °C(lit.)
• Vapor Pressure: 184mmHg at 25°C
• Refractive Index: n20/D 1.386(lit.)
• CAS DataBase Reference: (S)-(-)-1,2-Epoxybutane(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(-)-1,2-Epoxybutane(30608-62-9)
• EPA Substance Registry System: (S)-(-)-1,2-Epoxybutane(30608-62-9)

Safety Data

• Hazard Codes: F,T
• Statements: 20/21/22-34-40
• Safety Statements: 16-26-27-36/37/39-45
• RIDADR: UN 3022 3/PG 2
• WGK Germany: 3
• HazardClass: 3
• PackingGroup: II
• Hazardous Substances Data: 30608-62-9(Hazardous Substances Data)

Usage

Chemical Properties

Colorless liquid

Uses

Different sources of media describe the Uses of 30608-62-9 differently. You can refer to the following data:
1. (S)?-?(-?)?-?1,?2-?Epoxybutane is an epoxide reagent used in organic synthesis. Used in the synthesis of α-ethyltryptamines as dual dopamine-serotonin releasers.
2. (S)-(?)-1,2-Epoxybutane can be used:As a starting material to prepare (+)- and (?)-homononactic acids, which are used as intermediates in the total synthesis of a cyclic antibiotic tetranactin.To prepare a chiral phosphorus synthon, which is applicable in the synthesis of phytoprostane B1 type I.To prepare Eu3+-based precatalysts applicable in the Mukaiyama Aldol reaction in water.

InChI:InChI=1/C4H8O/c1-2-4-3-5-4/h4H,2-3H2,1H3/t4-/m0/s1

Upstream product

• 70379-72-5 (R)-2-acetoxy-1-bromobutane 
• 40348-66-1 (R)-1,2-butanediol 
• 72952-76-2 S-(-)-1-bromo-2-acetoxy-butane 
• 106-88-7 ethyloxirane 
• 917-61-3 sodium isocyanate 
• 93246-18-5 ((S)-2-Hydroxy-butyl)-trimethyl-ammonium; hydroxide 
• 124-38-9 carbon dioxide 
• 51-79-6 urethane 
• 56536-49-3 (2S)-2-chlorobutan-1-ol 
• 145021-04-1 (R)-1-tert-Butylsulfanyl-butan-2-ol 
• 136656-75-2 (R)-(-)-1-(benzenesulfanyl)-2-butanol 
• 93246-17-4 ((R)-2-Hydroxy-butyl)-trimethyl-ammonium; hydroxide 
• 143-33-9 sodium cyanide 
• 108269-46-1 (2R)-2-chlorobutan-1-ol 

Downstream Products

• 4476-77-1 (S)-3-tetradecanol 
• 1038436-21-3 (S)-(+)-1-[2-(benzyloxy)-5-tert-butylphenoxy]butan-2-ol 
• 198561-27-2 (R)-3-hydroxypentanenitrile 
• 67253-47-8 (R)-2-hydroxypropane-1-phenylsulfide 

Relevant articles and documents

Aromatic Donor-Acceptor Interaction-Based Co(III)-salen Self-Assemblies and Their Applications in Asymmetric Ring Opening of Epoxides

Aromatic donor-acceptor interaction as the driving force to assemble cooperative catalysts is described. Pyrene/naphthalenediimide functionalized Co(III)-salen complexes self-assembled into bimetallic catalysts through aromatic donor-acceptor interactions and showed high catalytic activity and selectivity in the asymmetric ring opening of various epoxides. Control experiments, nuclear magnetic resonance (NMR) spectroscopy titrations, mass spectrometry measurement, and X-ray crystal structure analysis confirmed that the catalysts assembled based on the aromatic donor-acceptor interaction, which can be a valuable noncovalent interaction in supramolecular catalyst development.

OXYSTEROLS AND METHODS OF USE THEREOF

Compounds are provided according to Formula (I): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein R2, R3, R4, R5, and and R6 are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.

Azidolysis of epoxides catalysed by the halohydrin dehalogenase from Arthrobacter sp. AD2 and a mutant with enhanced enantioselectivity: an (S)-selective HHDH

Halohydrin dehalogenase from Arthrobacter sp. AD2 catalysed azidolysis of epoxides with high regioselectivity and low to moderate (S)-enantioselectivity (E?=?1–16). Mutation of the asparagine 178 to alanine (N178A) showed increased enantioselectivity towards styrene oxide derivatives and glycidyl ethers. Conversion of aromatic epoxides was catalysed by HheA-N178A with complete enantioselectivity, however the regioselectivity was reduced. As a result of the enzyme-catalysed reaction, enantiomerically pure (S)-β-azido alcohols and (R)-α-azido alcohols (ee???99%) were obtained.