31169-25-2

Basic information

• Product Name: 7-BROMOTHIENO[3,2-D]PYRIMIDIN-4(1H)-ONE
• Synonyms: 7-BROMOTHIENO[3,2-D]PYRIMIDIN-4(1H)-ONE;7-bromothieno[3,2-d]pyrimidin-4(3H)-one;7-bromothieno[3,2-d]pyrimidin-4-ol;7-BroMo-3H-thieno[3,2-d]pyriMidin-4-one;7-broMo-1H,4H-thieno[3,2-d]pyriMidin-4-one;7-bromo-3H,4H-thieno[3,2-d]pyrimidin-4-one
• CAS NO: 31169-25-2
• Molecular Formula: C₆H₃BrN₂OS
• Molecular Weight: 231.08
• EINECS: 1308068-626-2
• Mol File: 31169-25-2.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 452.733 °C at 760 mmHg
• Flash Point: 227.605 °C
• Appearance: /
• Density: 2.18
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.854
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 10.19±0.20(Predicted)
• CAS DataBase Reference: 7-BROMOTHIENO[3,2-D]PYRIMIDIN-4(1H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-BROMOTHIENO[3,2-D]PYRIMIDIN-4(1H)-ONE(31169-25-2)
• EPA Substance Registry System: 7-BROMOTHIENO[3,2-D]PYRIMIDIN-4(1H)-ONE(31169-25-2)

Safety Data

• Hazardous Substances Data: 31169-25-2(Hazardous Substances Data)

Usage

General Description

7-Bromothieno[3,2-d]pyrimidin-4(1h)-one is a chemical compound classified under the family of Thienopyrimidinones, which are organic heterotricyclic compounds. The molecular formula of this compound is C6H2BrNOS indicating it is composed of the elements carbon, hydrogen, bromine, nitrogen, oxygen and sulfur. It's an organobromine and organooxygen compound which means it is used as an intermediate reagent in pharmaceutical and organic synthesis. However, there is limited information available about its other specific characteristics or uses. As always, precautions should be taken while handling or using this chemical compound due to potential health and safety risks.

InChI:InChI=1/C6H3BrN2OS/c7-3-1-11-5-4(3)8-2-9-6(5)10/h1-2H,(H,8,9,10)

Upstream product

• 16234-10-9 3H-thieno[3,2-d]pyrimidin-4-one 
• 22288-78-4 Methyl 3-aminothiophene-2-carboxylate 
• 31169-26-3 7-nitro-3H-thieno[3,2-d]pyrimidin-4-one 
• 1383531-54-1 7-amino-3H-thieno[3,2-d]pyrimidin-4-one 
• 16285-69-1 3-(formylamino)-2-thiophenecarboxylic acid methyl ester 

Downstream Products

• 31169-27-4 7-bromo-4-chlorothieno[3,2-d]pyrimidine 
• 1421230-73-0 C₂₁H₁₇N₃O₂S 
• 1421230-06-9 2-(4-(4-(4-(3-phenylureido)phenyl)thieno[3,2-d]pyrimidin-7-yl)phenyl)acetic acid 
• 1421230-72-9 methyl 2-(4-(4-(4-(tert-butoxycarbonylamino)phenyl)thieno[3,2-d]pyrimidin-7-yl)phenyl)acetate 
• 1421230-68-3 3-(4-(4-(3-(3-chlorophenyl)ureido)thieno[3,2-d]pyrimidin-7-yl)phenyl)propanoic acid 
• 1421230-76-3 methyl 3-(4-(4-aminothieno[3,2-d]pyrimidin-7-yl)phenyl)propanoate 
• 1421230-75-2 methyl 3-(4-(4-chlorothieno[3,2-d]pyrimidin-7-yl)phenyl)propanoate 
• 1421230-74-1 methyl 3-(4-(4-(methylthio)thieno[3,2-d]pyrimidin-7-yl)phenyl)propanoate 
• 1421230-65-0 2-(4-(4-(4-(pyrimidin-2-ylamino)phenyl)thieno[3,2-d]pyrimidin-7-yl)phenyl)acetic acid 
• 1421230-37-6 2-(4-(4-(4-(3-pyridazin-3-ylureido)phenyl)thieno[3,2-d]pyrimidin-7-yl)phenyl)acetic acid 
• 1446111-26-7 4-amino-N-(1-((4-chlorophenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide 
• 1318242-98-6 4-amino-thieno[3,2-d]pyrimidine-7-carboxylic acid 
• 1446112-30-6 4-amino-N-(1-((4-chloro-3-(piperazin-1-ylmethyl)phenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide hydrochloride 
• 1446112-28-2 tert-butyl 4-(5-((5-(4-aminothieno[3,2-d]pyrimidine-7-carboxamido)-6-methylisoquinolin-1-yl)amino)-2-chlorobenzyl)piperazine-1-carboxylate 

Relevant articles and documents

An Efficient Second-Generation Manufacturing Process for the pan-RAF Inhibitor Belvarafenib

Herein, the development of a streamlined manufacturing process for the pan-RAF inhibitor belvarafenib (GDC-5573) is reported. The process to belvarafenib features a number of efficient key reactions, including a robust and scalable Pd-catalyzed carbonylation reaction to generate thienopyrimidine 2 and a highly chemoselective Pt/V/C-catalyzed nitro group reduction to access the penultimate intermediate 3. The final amide coupling was accomplished by a mild and safe protocol employing N,N,N′,N′-tetramethylchloroformamidinium hexafluorophosphate as the coupling reagent, which afforded belvarafenib on a multikilogram production scale after recrystallization.

THIENO[3,2-D]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES

Provided are a thieno[3,2-d]pyrimidine derivative of formula (I) or a pharmaceutically acceptable salt thereof having inhibitory activity for protein kinase, and a pharmaceutical composition comprising same for prevention and treatment of abnormal cell growth diseases.

NOVEL PYRIMIDINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION INCLUDING SAME AS AN ACTIVE INGREDIENT

The present invention relates to a compound represented by formula (I) for inhibiting the activity of diacylglycerol O-acyltransferase type 1 (DGAT1), and pharmaceutically acceptable salts thereof, and a pharmaceutical composition comprising same as an active ingredient. The compound of the present invention may be used effectively in the treatment or prevention of a disease or condition mediated by the activity of DGAT1 such as obesity, type II diabetes, dyslipidemia, metabolic syndrome, and the like, without any adverse effects: wherein A, B, X, and R5 to R7 are the same as defined in the specification.