312-73-2Relevant articles and documents
Reactions of epoxides derived from internal perfluoroolefins with o-phenylenediamine and 2-aminophenol
Saloutina,Zapevalov,Saloutin,Kodess,Kirichenko,Pervova,Chupakhin
, p. 558 - 566 (2007/10/03)
The reactions of epoxy derivatives of internal perfluoroolefins with o-phenylenediamine and 2-aminophenol in dioxane gave 23-67% of the corresponding 2,3-bis(perfluoroalkyl)quinoxalines and 2,3-bis-(perfluoroalkyl)-2H-1,4- benzoxazin-2-ols, respectively. When N,N-dimethylacetamide was used as a solvent, the main reaction pathway was anionic isomerization of epoxides into ketones which were then converted into 2-perfluoroalkylbenzimidazoles (in the reactions with o-phenylenediamine) or 2-hydroxy-N-perfluoroalkanoylanilines (in the reactions with 2-aminophenol). The reaction of 3,4-epoxydodecafluorohexane with 2-aminophenol in N,N-dimethylacetamide was accompanied by unusual cyclization to afford 2-pentafluoropropanoyl-2-pentafluoroethyl-1,3- benzoxazolidine. Pleiades Publishing, Inc., 2006.
A novel method for preparation of trifluoromethyl substituted 2,3- dihydro-1,4-diazepine and benzimidazole
Chu, Qianli,Wang, Yanli,Zhu, Shizheng
, p. 677 - 687 (2007/10/03)
Ethylenediamine reacted readily with 4-ethoxy-1,1,1-trifluoro-3-butene- 2-one to form 5-trifluoromethyl-2,3-dihydro-1,4-diazepine in good yield. Under the same reaction conditions o-phenylene diamine gave 2-trifluoromethyl benzimidazole and benzimidazole.
Photochemical Perfluoroalkylation of Imidazoles
Kimoto, Hiroshi,Fujii, Shozo,Cohen, Louis A.
, p. 2867 - 2872 (2007/10/02)
Imidazole and its derivatives undergo facile trifluoromethylation or perfluoroalkylation, in methanol solution at ambient temperature, following radical dissociation of RFI by γ or UV irradiation.In the case of imidazole, attack occurs preferen
