312-85-6

Basic information

• Product Name: Sodium lactate
• Synonyms: PURASAL(R)S;PURASAL(R)S/HQ 60;PURASAL(R)S/PF 60;PURASAL(R)S/SP 60;SARCOLACTIC ACID SODIUM SALT;SODIUM-L-2-HYDROXY-PROPIONATE;SODIUM L-LACTATE;SODIUM L-LACTATE SOLUTION
• CAS NO: 312-85-6
• Molecular Formula: C₃H₅O₃*Na
• Molecular Weight: 112.06
• EINECS: 212-762-3
• Mol File: 312-85-6.mol
• Article Data: 20

Chemical Properties

• Melting Point: 163-165 °C(lit.)
• Boiling Point: 227.6oC at 760 mmHg
• Flash Point: 109.9oC
• Appearance: 50 APHA max./syrup
• Density: 1.33
• Refractive Index: 1.422-1.425
• Storage Temp.: 2-8°C
• Stability: Stable.
• CAS DataBase Reference: Sodium lactate(CAS DataBase Reference)
• NIST Chemistry Reference: Sodium lactate(312-85-6)
• EPA Substance Registry System: Sodium lactate(312-85-6)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 1
• RTECS: OD5680000
• F: 3-10
• Hazardous Substances Data: 312-85-6(Hazardous Substances Data)

Usage

Chemical Properties

liquid

Uses

Different sources of media describe the Uses of 312-85-6 differently. You can refer to the following data:
1. sodium lactate keeps a product’s pH from becoming too acidic. It is moisturizing and moisture binding, as well as being a keratolytic, helping exfoliate excess cells from the surface of the stratum corneum. It is also used as a substitute for glycerin. Sodium lactate is naturally occurring in the skin.
2. Sodium Lactate is a humectant that is the sodium salt of lactic acid which is low melting and hygroscopic with a mildly saline taste. it is used in sponge cake and swiss roll to produce a tender crumb and to reduce staling. it provides a protein plasticizing effect in bis- cuits. it is used in frankfurter-type sausages as a replacement for sodium chloride to extend shelf life and as a dehydrating salt or humectant in uncured hams. it can function as a flavoring agent and enhancer in some meat and poultry products.

InChI:InChI=1/C3H6O3.Na/c1-2(4)3(5)6;/h2,4H,1H3,(H,5,6);/q;+1

Synthetic route

sodium pyruvate (113-24-6) → sodium lactate (312-85-6)

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In methanol at 25℃;	100%
With [pentamethylcyclopentadienyl*Ir(N-phenyl-2-pyridinecarboxamidate)Cl]; sodium formate In methanol at 37℃; for 15h;	100 %Spectr.

glycerol (56-81-5) → sodium lactate (312-85-6)

Conditions	Yield
With water; C25H37IrN6(2+)*2F6P(1-); sodium hydroxide at 180℃; for 20h; Catalytic behavior; Reagent/catalyst; Autoclave;	73%
With sodium hydroxide In water at 179.84℃; for 4h; Catalytic behavior;
With carbonyl hydridoformate bis[2-(diisopropylphosphino)ethyl]amine iron(II); sodium hydroxide In 1-methyl-pyrrolidin-2-one; water at 140℃; for 3h; Catalytic behavior; Reagent/catalyst; Solvent; Temperature; Inert atmosphere;

Upstream product

• 142-10-9 DL-glyceraldehyde 3-phosphate 
• 492-62-6 alpha-D-glucopyranose 
• 40010-55-7 ¹³C-C₁-glucopyranose 
• 110-89-4 piperidine 
• 113-24-6 sodium pyruvate 
• 1310-73-2 sodium hydroxide 
• 57-55-6 propylene glycol 
• 116-09-6 hydroxy-2-propanone 
• 78-98-8 2-oxopropanal 
• 56-81-5 glycerol 
• 9004-34-6 cellulose 
• 849585-22-4 LACTIC ACID 
• 50-99-7 D-glucose 

Downstream Products

• 547-64-8 methyl lactate 
• 616-09-1 n-propyl lactate 
• 97-64-3 ethyl 2-hydroxypropionate 
• 19329-89-6 isopentyl lactate 
• 75-07-0 acetaldehyde 
• 15719-64-9 methylammonium carbonate 
• 2051-96-9 benzyl lactate 
• 535-17-1 2-acetoxypropionic acid 
• 30379-61-4 α-Propionyloxypropionaeure 
• 617-51-6 isopropyl lactate 
• 69028-44-0 lactic acid methallyl ester 
• 138-22-7 n-butyl lactate 
• 20279-51-0 n-hexyl lactate 
• 75-47-8 iodoform 

Relevant articles and documents

Selective conversion of glycerol to lactic acid with iron pincer precatalysts

A family of iron complexes of PNP pincer ligands are active catalysts for the conversion of glycerol to lactic acid with high activity and selectivity. These complexes also catalyse transfer hydrogenation reactions using glycerol as the hydrogen source.

Cannabichromene and Δ9-Tetrahydrocannabinolic Acid Identified as Lactate Dehydrogenase-A Inhibitors by in Silico and in Vitro Screening

Cannabis sativa contains >120 phytocannabinoids, but our understanding of these compounds is limited. Determining the molecular modes of action of the phytocannabinoids may assist in their therapeutic development. Ligand-based virtual screening was used to suggest novel protein targets for phytocannabinoids. The similarity ensemble approach, a virtual screening tool, was applied to target identification for the phytocannabinoids as a class and predicted a possible interaction with the lactate dehydrogenase (LDH) family of enzymes. In order to evaluate this in silico prediction, a panel of 18 phytocannabinoids was screened against two LDH isozymes (LDHA and LDHB) in vitro. Cannabichromene (CBC) and Δ9-tetrahydrocannabinolic acid (Δ9-THCA) inhibited LDHA via a noncompetitive mode of inhibition with respect to pyruvate, with Ki values of 8.5 and 6.5 μM, respectively. In silico modeling was then used to predict the binding site for CBC and Δ9-THCA. Both were proposed to bind within the nicotinamide pocket, overlapping the binding site of the cofactor NADH, which is consistent with the noncompetitive modes of inhibition. Stemming from our in silico screen, CBC and Δ9-THCA were identified as inhibitors of LDHA, a novel molecular target that may contribute to their therapeutic effects.

Efficient and Bio-inspired Conversion of Cellulose to Formic Acid Catalyzed by Metalloporphyrins in Alkaline Solution

A bio-inspired approach for efficient conversion of cellulose to formic acid (FA) was developed in an aqueous alkaline medium. Metalloporphyrins mimicking cytochrome P450 exhibit efficiently and selectively catalytic performance in catalytic conversion of cellulose. High yield of FA about 63.7% was obtained by using sulfonated iron(III) porphyrin as the catalyst and O2 as the oxidant. Iron(III)-peroxo species, TSPPFeIIIOO?, was involved to cleave the C-C bonds of gluconic acid to FA in this catalytic system. This approach used relatively high concentration of cellulose and ppm concentration of catalyst. This work may provide a bio-inspired route to efficient conversion of cellulose to FA.