31383-67-2

Basic information

• Product Name: Benzene, [[2-(chloromethoxy)ethoxy]methyl]-
• Synonyms: benzyloxyethoxymethylchloride;1-benzyloxy-2-chloromethoxy ethane
• CAS NO: 31383-67-2
• Molecular Formula: C10H13ClO2
• Molecular Weight: 200.665
• Mol File: 31383-67-2.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Benzene, [[2-(chloromethoxy)ethoxy]methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, [[2-(chloromethoxy)ethoxy]methyl]-(31383-67-2)
• EPA Substance Registry System: Benzene, [[2-(chloromethoxy)ethoxy]methyl]-(31383-67-2)

Safety Data

• Hazardous Substances Data: 31383-67-2(Hazardous Substances Data)

Upstream product

• 110-88-3 1,3,5-Trioxan 
• 622-08-2 2-Benzyloxyethanol 
• 50-00-0 formaldehyd 

Downstream Products

• 371973-40-9 dimethyl 1-(2-benzyloxyethoxymethyl)-4,5-imidazoledicarboxylate 
• 1062134-09-1 N-{2-[2-(2-benzyloxyethoxy)ethyl]-4-methoxy-pyridin-3-yl}-acetamide 
• 1062134-12-6 3-[3-(2-benzyloxyethoxy)-1-oxopropanamine]-4-methoxy-2-methylpyridine 
• 1062134-55-7 3-tert-butyl-N-[5-acetamido-4-{2-(2-benzyloxyethoxy)ethylpyridin-2-yl}] carbamate 
• 1062134-30-8 tert-butyl-N-[5-acetamido-6-{2-(2-benzyloxyethoxy)ethylpyridin-2-yl}] carbamate 
• 1062134-18-2 N-{4-[2-(2-benzyloxyethoxy)ethyl]-2-methoxypyridin-3-yl}-acetamide 
• 1303528-46-2 1-[(2-benzyloxyethoxy)methyl]-3-aminocarbonylpyridinium chloride 
• 132119-67-6 1-(2-Benzyloxy-ethoxymethyl)-4,5-bis-(4-chloro-phenyl)-1H-[1,2,3]triazole 
• 132119-58-5 1-<2-(benzyloxy)ethoxy>methyl-4,5-diphenyl-1,2,3-triazole 
• 132119-62-1 1-<2-(benzyloxy)ethoxy>methyl-4,5-dimethoxycarbonyl-1,2,3-triazole 
• 132119-68-7 1-<2-(benzyloxy)ethoxy>methyl-4,5-dicarboxamide-1,2,3-triazole 
• 132119-48-3 1-<2-(benzyloxy)ethoxy>methyl-5-phenyl-1,2,3-triazole 
• 132119-49-4 1-<2-(benzyloxy)ethoxy>methyl-4-phenyl-1,2,3-triazole 
• 132119-43-8 N-<2-(benzyloxy)ethoxy>methyl-3-azatricyclo<3.2.1.0^2,4-exo>octane 

Relevant articles and documents

Design, synthesis and biological characterization of novel inhibitors of CD38

Human CD38 is a novel multi-functional protein that acts not only as an antigen for B-lymphocyte activation, but also as an enzyme catalyzing the synthesis of a Ca2+ messenger molecule, cyclic ADP-ribose, from NAD+. It is well established that this novel Ca2+ signaling enzyme is responsible for regulating a wide range of physiological functions. Based on the crystal structure of the CD38/NAD+ complex, we synthesized a series of simplified N-substituted nicotinamide derivatives (Compound1-14). A number of these compounds exhibited moderate inhibition of the NAD+ utilizing activity of CD38, with Compound4 showing the highest potency. The crystal structure of CD38/Compound4 complex and computer simulation of Compound7 docking to CD38 show a significant role of the nicotinamide moiety and the distal aromatic group of the compounds for substrate recognition by the active site of CD38. Biologically, we showed that both Compounds4 and 7 effectively relaxed the agonist-induced contraction of muscle preparations from rats and guinea pigs. This study is a rational design of inhibitors for CD38 that exhibit important physiological effects, and can serve as a model for future drug development.

SYNTHESIS AND ANTIVIRAL ACTIVITY OF 1,2,3-TRIAZOLE AND 8-AZAPURINE DERIVATIVES BEARING ACYCLIC SUGARS

A variety of 1,2,3-triazole and 8-azapurine derivatives bearing acyclic sugar moieties were synthesized by the reaction of acyclic sugar azides with α-cyanoacetamide, norbornadiene, and acetylene derivatives, respectively.Antiviral tests of these compound

Synthesis of 1,2,3-triazolines and 8-azapurines bearing ring-openend sugar

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