31540-74-6Relevant articles and documents
Controlled α-mono- and α,α-di-halogenation of alkyl sulfones using reagent-solvent halogen bonding
Poteat, Christopher M.,Lindsay, Vincent N. G.
supporting information, p. 2912 - 2915 (2019/03/17)
The direct and selective α-mono-bromination of alkyl sulfones was achieved through base-mediated electrophilic halogenation. The appropriate combination of solvent and electrophilic bromine source was found to be critical to control the nature of the products formed, where reagent-solvent halogen bonding is proposed to control the selectivity via alteration of the effective size of the electrophilic bromine source. Conversely, the α,α-di-brominated sulfones were selectively obtained in good yields following polyhalogenation followed by selective de-halogenation during workup. Both procedures can be applied on gram scale, and the mono-halogenation was successfully extended to the fully selective α-chlorination, α-iodination and α-fluorination of alkyl sulfones.
A Regiospecific Reaction of Pyridazines with Vicarious Nucleophilic Substitution via Their Dicyanomethylide Derivatives
Itoh, Takashi,Matsuya, Yuji,Nagata, Kazuhiro,Okada, Mamiko,Ohsawa, Akio
, p. 2067 - 2068 (2007/10/02)
The phenyl(or p-tolyl)sulfonylmethyl group is introduced with complete regiospecificity to the C-4 position of 3-substituted pyridazines using vicarious nucleophilic substitution of pyridazinium dicyanomethylides.
Base-Induced Disproportionation of Halomethyl Phenyl sulfones to Methyl and Dihalomethyl Phenyl Sulfones
Galvagni, Marco,Kelleher, Fintan,Paradisi, Cristina,Scorrano, Gianfranco
, p. 4454 - 4456 (2007/10/02)
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