31600-42-7Relevant articles and documents
Discovery of novel 7-membered cyclic amide derivatives that inhibit 11beta-hydroxysteroid dehydrogenase type 1
Udagawa, Shuji,Sakami, Satoshi,Takemura, Takahiro,Sato, Mikiya,Arai, Takahiro,Nitta, Aiko,Aoki, Takumi,Kawai, Koji,Iwamura, Tomokatsu,Okazaki, Seiji,Takahashi, Takehiro,Kaino, Mie
supporting information, p. 1617 - 1621 (2013/04/10)
A series of novel 5-trans-hydroxyadamantan-2-yl-5,6,7,8- tetrahydropyrazolo[4,3-c]azepin-4(1H)-ones that inhibit 11beta-hydroxysteroid dehydrogenase type 1 are described. We discovered these 7-membered cyclic amide derivatives by introducing a distinctive linker through pharmacophore analysis of known ligands included in X-ray co-crystal structures. Further optimization using docking studies led to highly potent inhibitors 15b and 27, which furthermore showed the potent efficacy in in vivo studies.
Gold-catalyzed oxidative cleavage of aryl-substituted alkynyl ethers using molecular oxygen. Simultaneous degradation of C-H and single and triple carbon-carbon bonds under ambient conditions
Das, Arindam,Chaudhuri, Rupsha,Liu, Rai-Shung
scheme or table, p. 4046 - 4048 (2009/12/08)
We report the gold-catalyzed oxidative cleavage of aryl-substituted alkynyl ethers using molecular oxygen under ambient conditions; the transformation involves a remarkable cleavage of C-H, C-C and CC bonds simultaneously.
Peroxisome proliferator activated receptor alpha agonists
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, (2008/06/13)
The present invention is directed to compounds represented by the following structural formula, and pharmaceutically acceptable salts, solvates and hydrates thereof, R1 is a substituted or unsubstituted group selected from C1-C8 alky
