316364-45-1Relevant articles and documents
Design, synthesis, and biological evaluation of potent and selective amidino bicyclic factor Xa inhibitors
Han,Dominguez,Stouten,Park,Duffy,Galemmo Jr.,Rossi,Alexander,Smallwood,Wong,Wright,Luettgen,Knabb,Wexler
, p. 4398 - 4415 (2007/10/03)
Thrombotic diseases are a major cause of death and morbidity. Factor Xa (fXa) plays a vital role in the regulation of normal homeostasis and abnormal intravascular thrombus development in the blood coagulation cascade. A novel series of fXa inhibitors inc