31828-68-9

Basic information

• Product Name: L-HOMOCYSTEINE THIOLACTONE HYDROCHLORIDE
• Synonyms: L-Homocysteine thiolactone hydrochloride,L-2-Amino-4-mercaptobutyric acid 1,4-thiolactone hydrochloride;CAindexname:2(3H)-Thiophenone,3-aminodihydro-,hydr;(S)-3-Aminodihydro-2(3H)-thiophenone hydrochloride;L-HOMOCYSTEINE THIOLACTONE HCL*CRYST;-3-Aminodihydrothiophen-2(3H);2(3H)-THIOPHENONE, 3-AMINODIHYDRO-, HYDROCHLORIDE, (3S)-;2(3H)-THIOPHENONE, 3-AMINODIHYDRO-, HYDROCHLORIDE, L-;2(3H)-THIOPHENONE, 3-AMINODIHYDRO-, HYDROCHLORIDE, (S)-
• CAS NO: 31828-68-9
• Molecular Formula: C₄H₇NOS*ClH
• Molecular Weight: 153.63
• EINECS: 250-824-1
• Mol File: 31828-68-9.mol
• Article Data: 2

Chemical Properties

• Melting Point: 185-191 °C
• Boiling Point: 253.8 °C at 760 mmHg
• Flash Point: 107.3 °C
• Appearance: /
• Vapor Pressure: 0.0179mmHg at 25°C
• Storage Temp.: 2-8°C
• Solubility: Aqueous Acid (Slightly), DMSO (Slightly), Water (Slightly)
• BRN: 3911455
• CAS DataBase Reference: L-HOMOCYSTEINE THIOLACTONE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: L-HOMOCYSTEINE THIOLACTONE HYDROCHLORIDE(31828-68-9)
• EPA Substance Registry System: L-HOMOCYSTEINE THIOLACTONE HYDROCHLORIDE(31828-68-9)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• F: 1-8-9
• Hazardous Substances Data: 31828-68-9(Hazardous Substances Data)

Usage

Chemical Properties

Colourless solid

Uses

L-Homocysteine Thiolactone Hydrochloride is used to prepare substituted homocysteine analogs as inhibitors of peptidylglycine α-amidating monooxygenase. It is also used to synthesize (mercaptoacyl)alanylprolines as metalloprotease inhibitors.

Biochem/physiol Actions

L-Homocysteine thiolactone, an amine reactive agent, is used to study post-translational modification of proteins, especially at lysine residues.

InChI:InChI=1/C4H7NOS.ClH/c5-3-1-2-7-4(3)6;/h3H,1-2,5H2;1H/t3-;/m0./s1

Upstream product

• 6038-19-3 3-aminodihydrothiophen-2(3H)-one hydrochloride 
• 1051970-97-8 S-HCT ditoluoyltartrate 
• 1051970-96-7 S-HCT madelate 

Downstream Products

• 89807-04-5 D-[S-methyl-11C]methionine 
• 60305-58-0 L-[S-methyl-11C]methionine 
• 944389-99-5 N-(p-nitrobenzylidene)-2-oxotetrahydro-3-thiophenine 
• 6038-19-3 3-aminodihydrothiophen-2(3H)-one hydrochloride 
• 1341220-51-6 (S)-2-amino-4-((((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3-(benzyloxy)-4-hydroxytetrahydrofuran-2-yl)methyl)thio)butanoic acid 
• 1341220-52-7 (S)-2-amino-4-((((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-(benzyloxy)-3-hydroxytetrahydrofuran-2-yl)methyl)thio)butanoic acid 
• 1341220-53-8 (S)-2-amino-4-((((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-bis(benzyloxy)tetrahydrofuran-2-yl)methyl)thio)butanoic acid 
• 56-88-2 L-cystathionine 
• 1595282-56-6 (S)-4-((3-((6-amino-9H-purin-9-yl)methyl)phenyl)methylthio)-2-aminobutanoic acid 
• 111109-99-0 (S)-2-amino-4-((((2S,3S,4R,5S)-5-(6-(benzylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)thio)butanoic acid 
• 202284-85-3 (S)-N-butyryl homocysteine thiolactone 
• 66608-10-4 N-6-chloronicotinoyl-d,l-homocysteine thiolactone 
• 6027-13-0 L-homocysteine 
• 38869-92-0 (3S,6S)-3,6-bis(2-sulfanylethyl)piperazine-2,5-dione 

Relevant articles and documents

COMPOSITIONS AND METHODS FOR CYCLOFRUCTANS AS SEPARATION AGENTS

The present invention relates to derivatized cyclofructan compounds, compositions comprising derivatized cyclofructan compounds, and methods of using compositions comprising derivatized cyclofructan compounds for chromatographic separations of chemical species, including enantiomers. Said compositions may comprise a solid support and/or polymers comprising derivatized cyclofructan compounds.