31970-04-4

Basic information

• Product Name: BENZYL 3-PYRROLINE-1-CARBOXYLATE 90
• Synonyms: benzyl 2,5-dihydro-1H-pyrrole-1-carboxylate;N-(Benzyloxycarbonyl)3-pyrroline;2,5-Dihydropyrrole-1-Cbz;N-Cbz-2,5-dihydropyrrole;N-Cbz-3-pyrroline;3-pyrroline-1-benzylcarboxylate;N-Carbobenzoxy-3-pyrroline;benzyl 2H-pyrrole-1(5H)-carboxylate
• CAS NO: 31970-04-4
• Molecular Formula: C₁₂H₁₃NO₂
• Molecular Weight: 203.24
• Product Categories: Building Blocks;Heterocyclic Building Blocks;Pyrrolines
• Mol File: 31970-04-4.mol
• Article Data: 43

Chemical Properties

• Boiling Point: 133-137 °C0.6 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: Colorless to pale yellow/Liquid
• Density: 1.132 g/mL at 25 °C(lit.)
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: n20/D 1.544(lit.)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: -1.51±0.20(Predicted)
• CAS DataBase Reference: BENZYL 3-PYRROLINE-1-CARBOXYLATE 90(CAS DataBase Reference)
• NIST Chemistry Reference: BENZYL 3-PYRROLINE-1-CARBOXYLATE 90(31970-04-4)
• EPA Substance Registry System: BENZYL 3-PYRROLINE-1-CARBOXYLATE 90(31970-04-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 31970-04-4(Hazardous Substances Data)

Usage

Chemical Properties

Colorless liquid

Uses

Benzyl 3-Pyrroline-1-carboxylate is an heterocyclic building block used in the synthesis of pharmaceutical products including inhibitors. It is used in synthesis of novel series of pyrrolotriazine, acting as a pan-Aurora kinase inhibitors.

InChI:InChI=1/C12H13NO2/c14-12(13-8-4-5-9-13)15-10-11-6-2-1-3-7-11/h1-7H,8-10H2

Upstream product

• 109-96-6 3-Pyrroline 
• 501-53-1 benzyl chloroformate 
• 1885-14-9 phenyl chloroformate 
• 100858-33-1 (3R)-3-hydroxy-pyrrolidine-1-carboxylic acid benzyl ester 
• 98-88-4 benzoyl chloride 
• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 
• 75315-63-8 N-(benzyloxycarbonyl)succinimide 
• 6913-92-4 1-benzyl-2,5-dihydro-1H-pyrrole 
• 63468-63-3 2,5-dihydro-1H-pyrrole hydrochloride 
• 95656-88-5 benzyl 3-hydroxypyrrolidine-1-carboxylate 
• 25070-76-2 benzyl diallylcarbamate 

Downstream Products

• 163439-83-6 (+)-(3R,4R)-1-benzyloxycarbonyl-3,4-dihydroxypyrrolidine 
• 134575-38-5 3-benzyl 6-ethyl (1α,5α,6β)-3-azabicyclo[3.1.0]hexane-3,6-dicarboxylate 
• 146726-10-5 3-benzyl 6-ethyl (1α,5α,6α)-3-azabicyclo[3.1.0]hexane-3,6-dicarboxylate 
• 945634-17-3 C₂₁H₂₅NO₆ 
• 1269755-12-5 (3S,4S)-benzyl 3-fluoro-4-vinylpyrrolidine-1-carboxylate 
• 1269755-19-2 (3R,4S)-benzyl 3-hydroxy-4-vinylpyrrolidine-1-carboxylate 
• 1269755-18-1 (3S,4R)-benzyl 3-hydroxy-4-vinylpyrrolidine-1-carboxylate 
• 1269755-11-4 (3R,4S)-1-(benzyloxycarbonyl)-4-fluoropyrrolidine-3-carboxylic acid 
• 1269755-14-7 (3S,4S)-benzyl 3-(4-methoxybenzoyloxy)-4-vinylpyrrolidine-1-carboxylate 
• 1269755-15-8 (3S,4S)-benzyl 3-hydroxy-4-vinylpyrrolidine-1-carboxylate 
• 1269755-16-9 (3S,4S)-benzyl 3-(tert-butyldiphenylsilyloxy)-4-vinylpyrrolidine-1-carboxylate 
• 1269755-13-6 (3S,4S)-1-(benzyloxycarbonyl)-4-(tert-butyldiphenylsilyloxy)-pyrrolidine-3-carboxylic acid 
• 1269755-20-5 (3R,4S)-benzyl 3-(tert-butyldiphenylsilyloxy)-4-vinylpyrrolidine-1-carboxylate 
• 1269755-17-0 (3S,4R)-1-(benzyloxycarbonyl)-4-(tert-butyldiphenylsilyloxy)-pyrrolidine-3-carboxylic acid 

Relevant articles and documents

Completely Recyclable Monomers and Polycarbonate: Approach to Sustainable Polymers

It is of great significance to depolymerize used or waste polymers to recover the starting monomers suitable for repolymerization reactions that reform recycled materials no different from the virgin polymer. Herein, we report a novel recyclable plastic: degradable polycarbonate synthesized by dinuclear chromium-complex-mediated copolymerization of CO2 with 1-benzyloxycarbonyl-3,4-epoxy pyrrolidine, a meso-epoxide. Notably, the novel polycarbonate with more than 99 % carbonate linkages could be recycled back into the epoxide monomer in quantitative yield under mild reaction conditions. Remarkably, the copolymerization/depolymerization processes can be achieved by the ON/OFF reversible temperature switch, and recycled several times without any change in the epoxide monomer and copolymer. These characteristics accord well with the concept of perfectly sustainable polymers.

DEUTERATED HETEROCYCLIC COMPOUNDS AND THEIR USE AS IMAGING AGENTS

The present invention relates to deuterated and optionally detectably labeled compounds of formula (I): R1-A-R2 and formula (V) and salts thereof, wherein Rl, R2, A, and X10-X19 have any of

Tandem ring-closing metathesis/transfer hydrogenation: Practical chemoselective hydrogenation of alkenes

An operationally simple chemoselective transfer hydrogenation of alkenes using ruthenium metathesis catalysts is presented. Of great practicality, the transfer hydrogenation reagents can be added directly to a metathesis reaction and effect hydrogenation of the product alkene in a single pot at ambient temperature without the need to seal the vessel to prevent hydrogen gas escape. The reduction is applicable to a range of alkenes and can be performed in the presence of aryl halides and benzyl groups, a notable weakness of Pd-catalyzed hydrogenations. Scope and mechanistic considerations are presented.