3230-94-2

Basic information

• Product Name: L-Ornithine L-aspartate salt
• Synonyms: ormeta;ornithineaspartate;ornithylaspartate;orparan;L-ORNITHINE L-ASPARTATE;L-ORNITHINE L-ASPARTATE SALT;L-2,5-DIAMINOPENTANOIC ACID L-ASPARTATE SALT;(s)-2,5-diaminopentanoic acid l-aspartate salt
• CAS NO: 3230-94-2
• Molecular Formula: C₄H₇NO₄*C₅H₁₂N₂O₂
• Molecular Weight: 265.26
• EINECS: 221-772-7
• Product Categories: Nutritional Supplements;amino acid;Other APIs
• Mol File: 3230-94-2.mol

Chemical Properties

• Melting Point: 202.0 to 206.0 °C
• Boiling Point: 308.7 °C at 760 mmHg
• Flash Point: 140.5 °C
• Appearance: white/powder
• Storage Temp.: 2-8°C
• Solubility: Aqueous Acid (Sparingly)
• Merck: 14,6874
• CAS DataBase Reference: L-Ornithine L-aspartate salt(CAS DataBase Reference)
• NIST Chemistry Reference: L-Ornithine L-aspartate salt(3230-94-2)
• EPA Substance Registry System: L-Ornithine L-aspartate salt(3230-94-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39-24/25
• WGK Germany: 2
• RTECS: CI9463000
• Hazardous Substances Data: 3230-94-2(Hazardous Substances Data)

Usage

Chemical Properties

White powder

Uses

L-Ornithine L-Aspartate Salt is used as a therapeutic agent in the treatment of hepatic encephalopathy and hepatitis.

Biochem/physiol Actions

L-Ornithine L-aspartate is a metabolite of arginine degradation by arginase. It has been shown to reduce blood ammonia concentrations by increasing ammoniadetoxification in the muscle and reducing the severity of hepatic encephalopathy in cirrhosis.

InChI:InChI=1/C5H12N2O2.C4H7NO4/c6-3-1-2-4(7)5(8)9;5-2(4(8)9)1-3(6)7/h4H,1-3,6-7H2,(H,8,9);2H,1,5H2,(H,6,7)(H,8,9)/p-1/t4-;2-/m00/s1

Synthetic route

L-Aspartic acid (56-84-8) + L-ornithine acetate (60259-81-6) → L-ornithine-L-aspartate salt (3230-94-2)

Conditions	Yield
With ammonium carbonate In methanol; water at 70 - 80℃; for 4.16667h; pH=7 - 8; Solvent;	18.3 g
In methanol at 45℃; Solvent;	21.3 g

L-Aspartic acid (56-84-8) + L-arginine (74-79-3) → L-ornithine-L-aspartate salt (3230-94-2)

Conditions	Yield
With zinc(II) chloride at 35 - 40℃; for 1.5h; pH=8.3; Reagent/catalyst; Temperature; pH-value;	115 g

Upstream product

• 56-84-8 L-Aspartic acid 
• 60259-81-6 L-ornithine acetate 
• 74-79-3 L-arginine 

Relevant articles and documents

Industrial preparation method of ornithine aspartate (by machine translation)

The industrial preparation method of the ornithine ornithine aspartate according 8 - 10, pH to the present invention, has the advantages of: simplicity L - in preparation process, first high purity of the product, low content of impurities of, the product, high, safety, second and low cost, and is suitable pH for 6 - 8, industrial production, and the like. (by machine translation)

Preparation method of L-ornithine-L-asparate double salt compound

The invention provides a preparation method of an L-ornithine-L-asparate double salt compound. The preparation method includes: 1) dissolving L-ornithine in a proper amount of water, adding L-asparatefor salt forming reaction, adding a proper amount of alkali to neutralize after salt forming reaction is complete so as to obtain a reaction system containing the L-ornithine-L-asparate double salt compound, and cooling, wherein the mole ratio between the L-ornithine and the L-asparate is 1:1; 2) filtering after cooling, adding obtained filtrate into a proper amount of preheated hydrophilic solution, stirring at a constant temperature, cooling, filtering, washing and drying to obtain the L-ornithine-L-asparate double salt compound. The preparation method has few processing steps, the obtainedL-ornithine-L-asparate double salt compound is high in purity and stability and can be sterilized by a terminal excessive killing method, potential medication safety hazards are reduced greatly, andproduction cost is reduced remarkably.

Preparation method of ornithine aspartate

The invention relates to a preparation method of ornithine aspartate. The preparation method comprises the following steps: adding ammonium carbonate serving as an acid-binding agent into L-ornithine acetate and L-aspartate which serve as original raw materials to neutralize acetate of L-ornithine acetate, so as to obtain free L-ornithine; carrying out a reaction on L-ornithine and L-aspartate to generate salts of L-ornithine and L-aspartate, namely generating ornithine aspartate; and then removing ammonium acetate according to the dissolvability difference between ornithine aspartate and ammonium acetate in a crystallization solvent, and obtaining pure ornithine aspartate. According to the preparation method, ammonium carbonate replaces ammonia water, so that the shortcomings in a preparation process in the prior art are overcome; and the synthesis method is simple in process, safe, environmentally-friendly, high in efficiency, low in cost, high in product purity and convenient for industrial production.