324-03-8

Basic information

• Product Name: 6-FLUOROISATIN
• Synonyms: 6-fluoroindoline-2,3-dione;6-fluoro-2,3-dihydro-1H-indole-2,3-dione;6-fluorolsatin;BUTTPARK 50\07-100;6-FLUOROISATIN;6-FLUORO-1H-INDOLE-2,3-DIONE;6-FLUOROISATIN, 98.5%;6-Fluoroisatine
• CAS NO: 324-03-8
• Molecular Formula: C₈H₄FNO₂
• Molecular Weight: 165.12
• EINECS: 1533716-785-6
• Mol File: 324-03-8.mol
• Article Data: 18

Chemical Properties

• Melting Point: 195-196 °C(Solv: acetic acid (64-19-7))
• Appearance: /
• Density: 1.477 g/cm³
• Refractive Index: 1.584
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 8.86±0.20(Predicted)
• CAS DataBase Reference: 6-FLUOROISATIN(CAS DataBase Reference)
• NIST Chemistry Reference: 6-FLUOROISATIN(324-03-8)
• EPA Substance Registry System: 6-FLUOROISATIN(324-03-8)

Safety Data

• Hazardous Substances Data: 324-03-8(Hazardous Substances Data)

Usage

General Description

6-Fluoroisatin is a chemical compound with the molecular formula C8H5FO2. It is a bright yellow solid with a melting point of 84-86 degrees Celsius. 6-Fluoroisatin is used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. It is also utilized in the production of dyes, pigments, and fluorescent materials. The compound exhibits potential therapeutic applications, including anti-microbial and anti-cancer properties, making it a subject of interest in the pharmaceutical industry. Additionally, 6-Fluoroisatin is known for its ability to undergo various chemical reactions, allowing for its incorporation into diverse synthetic pathways.

InChI:InChI=1/C8H4FNO2/c9-4-1-2-5-6(3-4)10-8(12)7(5)11/h1-3H,(H,10,11,12)

Upstream product

• 372-19-0 meta-fluoroaniline 
• 302-17-0 chloral hydrate 
• 350-78-7 3-fluoro-isonitrosoacetanilide 
• 399-51-9 6-fluoro-1H-indole 
• 350-78-7 (2E)-N-(3-fluorophenyl)-2-hydroxyiminoacetamide 

Downstream Products

• 120624-73-9 3-[2-(3-Chloro-4-fluoro-phenyl)-2-oxo-eth-(Z)-ylidene]-6-fluoro-1,3-dihydro-indol-2-one 
• 113333-95-2 C₁₇H₁₀ClF₂NO₂ 
• 124028-66-6 7-fluoro-3-(2-methoxyphenyl)-2(1H)-quinolinone 
• 41042-21-1 (1-ethoxycarbonylmethyl)isatin 
• 1391858-21-1 (2'S,3'R,4'S)-5',5'-diethyl 3',4'-dimethyl 1-benzyl-6-fluoro-2-oxospiro[indoline-3,2'-pyrrolidine]-3',4',5',5'-tetracarboxylate 
• 1431566-07-2 (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(6-morpholino-2,3-dioxoindolin-1-yl)acetoxy)ethyl)pyridine 1-oxide 
• 1431566-10-7 (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(6-fluoro-2,3-dioxoindolin-1-yl)acetoxy)-ethyl)pyridine 1-oxide 
• 1446679-48-6 C₂₂H₂₀FN₃O₅ 
• 1446679-49-7 C₂₂H₁₉ClFN₃O₄ 
• 1446679-50-0 C₂₇H₂₁F₃N₄O₄ 
• 871125-39-2 C₁₄H₁₀FN₃O 
• 1315268-71-3 5'-fluoro-1,3-diphenyl-1H-spiro[indeno[1,2-b]pyrazolo[4,3-e]pyridine-4,3'-indoline]-2',5(10H)-dione 

Relevant articles and documents

19F magnetic resonance probes for live-cell detection of peroxynitrite using an oxidative decarbonylation reaction

We report a newly discovered oxidative decarbonylation reaction of isatins that is selectively mediated by peroxynitrite (ONOO-) to provide anthranilic acid derivatives. We have harnessed this rapid and selective transformation to develop two reaction-based probes, 5-fluoroisatin and 6-fluoroisatin, for the low-background readout of ONOO- using 19F magnetic resonance spectroscopy. 5-fluoroisatin was used to non-invasively detect ONOO- formation in living lung epithelial cells stimulated with interferon-γ (IFN-γ). This journal is

Discovery of Novel Schizocommunin Derivatives as Telomeric G-Quadruplex Ligands That Trigger Telomere Dysfunction and the Deoxyribonucleic Acid (DNA) Damage Response

Telomeric G-quadruplex targeting and telomere maintenance interference are emerging as attractive strategies for anticancer therapies. Here, a novel molecular scaffold is explored for telomeric G-quadruplex targeting. A series of novel schizocommunin derivatives was designed and synthesized as potential telomeric G-quadruplex ligands. The interaction of telomeric G-quadruplex DNA with the derivatives was explored by biophysical assay. The cytotoxicity of the derivatives toward cancer cell lines was evaluated by the methyl thiazolyl tetrazolium (MTT) assay. Among the derivatives, compound 16 showed great stabilization ability toward telomeric G-quadruplex DNA and good cytotoxicity toward cancer cell lines. Further cellular experiments indicated that 16 could induce the formation of telomeric G-quadruplex in cells, triggering a DNA damage response at the telomere and causing telomere dysfunction. These effects ultimately provoked p53-mediated cell cycle arrest and apoptosis, and suppressed tumor growth in a mouse xenograft model. Our work provides a novel scaffold for the development of telomeric G-quadruplex ligands.

A NOVEL PROCESS FOR THE PREPARATION OF TRYPTAMINES AND DERIVATIVES THEREOF

The present invention relates to a novel process for the preparation of tryptamine, its substituted derivatives and intermediates for the preparation of them.