3245-49-6

Basic information

• Product Name: 1-(4-(3-bromopropoxy)- 3-methoxyphenyl)ethanone
• Synonyms: 1-(4-(3-bromopropoxy)- 3-methoxyphenyl)ethanone
• CAS NO: 3245-49-6
• Molecular Formula: C₁₂H₁₅BrO₃
• Molecular Weight: 287
• Mol File: 3245-49-6.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Density: 1.334
• CAS DataBase Reference: 1-(4-(3-bromopropoxy)- 3-methoxyphenyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-(3-bromopropoxy)- 3-methoxyphenyl)ethanone(3245-49-6)
• EPA Substance Registry System: 1-(4-(3-bromopropoxy)- 3-methoxyphenyl)ethanone(3245-49-6)

Safety Data

• Hazardous Substances Data: 3245-49-6(Hazardous Substances Data)

Usage

Uses

1-(4-(3-Bromopropoxy)-3-methoxyphenyl)ethanone is a reagent used for preparation of psychotropic agent iloperidone.

Upstream product

• 109-64-8 1,3-dibromo-propane 
• 498-02-2 1-(3-methoxy-4-hydroxyphenyl)ethanone 
• 109-70-6 1.3-chlorobromopropane 

Downstream Products

• 47553-92-4 N-<2-(2-Methoxy-phenoxy)-aethyl>-3-<4-acetyl-2-methoxy-phenoxy>-propylamin 
• 198133-52-7 1-[4-[3-(7-fluoro-1,4-dihydrospiro[cyclopent[b]indole-3(2H),4'-piperidine]-1'-yl)propoxy]-3-methoxyphenyl]ethanone 
• 1446339-55-4 (S)-3-{1-[3-(4-acetyl-2-methoxyphenoxy)propyl]piperidin-2-yl}pyridine oxalate 
• 133454-47-4 iloperidone 
• 1184831-17-1 1-[5-methoxy-4-(3-bromo-propoxy)-2-nitro-phenyl]-ethanone 
• 152808-10-1 1-[4-[3-[4-(6-fluorobenzo[b]thiophen-3-yl)-1-piperazinyl]propoxy]-3-methoxyphenyl]ethanone 
• 1160707-44-7 1-[4-(3-chloropropoxy)-5-methoxy-2-nitrophenyl]ethan-1-one 

Relevant articles and documents

Iron-catalyzed domino decarboxylation-oxidation of α,β-unsaturated carboxylic acids enabled aldehyde C-H methylation

A practical and general iron-catalyzed domino decarboxylation-oxidation of α,β-unsaturated carboxylic acids enabling aldehyde C-H methylation for the synthesis of methyl ketones has been developed. This mild, operationally simple method uses ambient air as the sole oxidant and tolerates sensitive functional groups for the late-stage functionalization of complex natural-product-derived and polyfunctionalized molecules.

Synthesis of N-aryloxyalkylanabasine derivatives

N-Aryloxyalkylanabasine derivatives were prepared via the reaction of anabasine hydrochloride with various aryloxyhaloalkanes in the presence of potash in DMF. The reaction occurred with retention of the chiral center C-(2) of the piperidine group. Side products of bis(aryloxy)ethanes were characterized.

PROCESS FOR THE PREPARATION OF ILOPERIDONE

The present invention relates to a novel process for the preparation of iloperidone (I) that comprises reaction of 1-[4-(3-halopropoxy)-3-methoxyphenyl] ethanone (IIIa / IIIb) with 6- fluoro-3-(piperidine-4-yl)-1,2-benzisoxazole hydrochloride (II) under pressure in an autoclave.