3257-71-4

Basic information

• Product Name: 2'-O,3'-O-Benzylideneuridine
• Synonyms: 2'-O,3'-O-Benzylideneuridine
• CAS NO: 3257-71-4
• Molecular Formula: C₁₆H₁₆N₂O₆
• Molecular Weight: 332.31
• Mol File: 3257-71-4.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2'-O,3'-O-Benzylideneuridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-O,3'-O-Benzylideneuridine(3257-71-4)
• EPA Substance Registry System: 2'-O,3'-O-Benzylideneuridine(3257-71-4)

Safety Data

• Hazardous Substances Data: 3257-71-4(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 58-96-8 uridine 
• 87418-77-7 5'-O-(tert-butyldimethylsilyl)uridine 
• 820212-22-4 5'-O-tert-butyldimethylsilyl-2',3'-O-bis(benzyloxycarbonyl)uridine 
• 820212-19-9 2′,3′-O-bis-(benzyloxycarbonyl)uridine 
• 1125-88-8 benzaldehyde dimethyl acetal 
• 4222-25-7 3-bromo-3-phenyl-3H-diazirine 

Downstream Products

• 3257-85-0 3’-O-benzoyl-2,2’-anhydro-1-(β-D-arabinofuranosyl)uracil 
• 5627-05-4 5,6-dihydrouridine 
• 33001-07-9 O^3'-benzoyl-2'-bromo-2'-deoxy-uridine 
• 3736-77-4 2,2'-Anhydrouridine 
• 620168-79-8 2',3'-O-benzylidene-5'-C-(nitromethyl)uridine 
• 58-97-9 5'-Uridylic Acid 
• 26301-95-1 O^2'_,O3'-benzylidene-5'-oxo-5'-deoxy-uridine 

Relevant articles and documents

Facile deprotection of O-Cbz-protected nucleosides by hydrogenolysis: An alternative to O-benzyl ether-protected nucleosides

(Chemical Equation Presented) Because of side-reactions encountered during hydrogenolysis, benzyl ethers are usually not an effective protecting group for nucleosides. Benzyloxycarbamates provide an alternative to traditional benzyl ethers for protection of nucleoside hydroxyl groups, as they are much more labile to hydrogenolysis. Deprotection conditions using transfer hydrogenolysis are described that avoid the reduction of the pyrimidine nucleobase during deblocking of O-Cbz-protected nucleosides. Additionally, an experiment is described that suggests the nucleobase component of a nucleoside is responsible for the sluggish hydrogenolysis of nucleosides.