3258-84-2

Basic information

• Product Name: N-(1-PHENETHYL-PIPERIDIN-4-YL)-N-PHENYL-ACETAMIDE
• Synonyms: N-(1-PHENETHYL-PIPERIDIN-4-YL)-N-PHENYL-ACETAMIDE;Acetamide, N-phenyl-N-[1-(2-phenylethyl)-4-piperidinyl]-;Acetanilide, N-(1-phenethyl-4-piperidyl)-;Fentanyl acetyl analog;N-Phenyl-N-[1-(2-phenylethyl)-4-piperidinyl]acetamide;1-Phenethyl-4-(N-phenylacetamido)piperidin;Acetyl Fentanyl;N-(1-Phenethyl-4-piperidylacetanilide
• CAS NO: 3258-84-2
• Molecular Formula: C₂₁H₂₆N₂O
• Molecular Weight: 322.44
• EINECS: 200-659-6
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 3258-84-2.mol
• Article Data: 3

Chemical Properties

• Melting Point: 93-95?C
• Boiling Point: 453.8 °C at 760 mmHg
• Flash Point: 9℃
• Appearance: /
• Density: 1.1 g/cm³
• Vapor Pressure: 2.01E-08mmHg at 25°C
• Refractive Index: 1.591
• Storage Temp.: Controlled Substance, -20?C Freezer
• PKA: 8.92±0.10(Predicted)
• CAS DataBase Reference: N-(1-PHENETHYL-PIPERIDIN-4-YL)-N-PHENYL-ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(1-PHENETHYL-PIPERIDIN-4-YL)-N-PHENYL-ACETAMIDE(3258-84-2)
• EPA Substance Registry System: N-(1-PHENETHYL-PIPERIDIN-4-YL)-N-PHENYL-ACETAMIDE(3258-84-2)

Safety Data

• Hazard Codes: Xn,Xi,T,F
• Statements: 22-36/37/38-39/23/24/25-23/24/25-11
• Safety Statements: 26-45-36/37-16-7
• RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
• WGK Germany: 1
• Hazardous Substances Data: 3258-84-2(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Solid

Uses

A Fentanyl analog. Controlled Substance

General Description

A certified Snap-N-Spike? solution suitable for use as starting material in calibrators and controls for fentanyl LC/MS or GC/MS testing methods in clinical toxicology, urine drug testing, prescription monitoring, or forensic analysis applications. Acetyl fentanyl is a designer drug and fentanyl analog with a potency 40 times greater than heroin and 80 times greater than morphine. This Certified Spiking Solution? is supplied in a convenient, quantitative, US DEA-exempt solution format and with TK #s for Canadian customers.

InChI:InChI=1/C21H26N2O/c1-18(24)23(20-10-6-3-7-11-20)21-13-16-22(17-14-21)15-12-19-8-4-2-5-9-19/h2-11,21H,12-17H2,1H3

Upstream product

• 62-53-3 aniline 
• 21409-26-7 (1-Phenethyl-piperidin-4-yl)-phenyl-amine 
• 75-36-5 acetyl chloride 
• 57958-48-2 N-(1-phenethylpiperidin-4-ylidene)aniline 
• 103-63-9 1-phenyl-2-bromoethane 
• 41979-39-9 4-piperidone hydrochloride 
• 39742-60-4 1-(2-phenylethyl)-4-piperidinone 
• 108-24-7 acetic anhydride 

Downstream Products

• 117332-89-5 N-<1-(2-Phenylethyl)-4-piperidyl>-N-phenylacetamide Hydrochloride 

Relevant articles and documents

Evaluation of agonistic activity of fluorinated and nonfluorinated fentanyl analogs on μ-opioid receptor using a cell-based assay system

The agonistic activity of fluorinated and nonfluorinated fentanyl analogs on μ-opioid receptor was investigated using a cell-based assay system. Based on the activity, fentanyl analogs were ranked as follows: fentanyl>isobutyrylfentanyl≈butyrylfentanyl≈methoxyacetylfentanyl>acetylfentanyl. However, among the fentanyl analogs fluorinated on the Nphenyl ring, 2-fluoro analogs and 3-fluoro analogs showed the strongest and weakest activities, respectively. These results suggest that the 2-fluorinated isomers of fentanyl analogs are more likely to cause poisoning.

Carbon-13 nuclear magnetic resonance spectra of fentanyl analogs

Natural abundance carbon-13 chemical shifts are reported for the hydrochloride salts of fentanyl and fifteen analogs. The signals are assigned on the basis of chemical shift theory, SFORD multiplicities, signal intensities, comparisons with model compounds, and thiophene carbon-proton coupling constants. In addition to its forensic value, the data suggest that the solution conformations of the analogs are similar to that of fentanyl hydrochloride.