32795-52-1

Basic information

• Product Name: O-ETHYL-L-TYROSINE
• Synonyms: H-TYR(ET)-OH;O-ETHYL-L-TYROSINE;L-Tyrosine, O-ethyl-;(S)-2-AMino-3-(4-ethoxyphenyl)propanoic acid;NSC 44162;3-(p-Ethoxyphenyl)-L-alanine
• CAS NO: 32795-52-1
• Molecular Formula: C₁₁H₁₅NO₃
• Molecular Weight: 209.24
• Mol File: 32795-52-1.mol
• Article Data: 3

Chemical Properties

• Melting Point: 236 °C
• Boiling Point: 362.3±32.0 °C(Predicted)
• Appearance: /
• Density: 1.175±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 2.24±0.10(Predicted)
• CAS DataBase Reference: O-ETHYL-L-TYROSINE(CAS DataBase Reference)
• NIST Chemistry Reference: O-ETHYL-L-TYROSINE(32795-52-1)
• EPA Substance Registry System: O-ETHYL-L-TYROSINE(32795-52-1)

Safety Data

• Hazardous Substances Data: 32795-52-1(Hazardous Substances Data)

Usage

General Description

O-Ethyl-L-Tyrosine is an artificial compound derived from the naturally occurring amino acid, tyrosine. It is classified as a tyrosine derivative and is categorized under the broad group of organic compounds known as amino acids, peptides, and analogues. Ethyl esterification has been found to enhance the lipophilic property of tyrosine and thus may enhance its blood–brain barrier (BBB) penetration. This chemical compound can be encountered in different types of health supplements for it may show potential to increase mental performance, alertness, and overall cognition. However, despite these purported benefits, comprehensive research is yet to be conducted to fully elucidate its safety, efficacies, and possible side effects on the human body.

Upstream product

• 3799-87-9 methyl (2,2,2-trifluoroacetyl)-L-tyrosinate 
• 3417-91-2 L-tyrosine methyl ester HCl 
• 60-18-4 L-tyrosine 
• 76757-91-0 N-tert-butoxycarbonyl-O-ethyl-L-tyrosine 
• 64-67-5 diethyl sulfate 
• 537-55-3 N-acetyl-L-tyrosine 

Downstream Products

• 405237-92-5 (αS)-α-[(4-ethoxyphenyl)methyl]-1,3-dihydro-1,3-dioxo-2H-isoindole-2-acetic acid 
• 82057-54-3 o-nitrobenzenesulfenyl-O-ethyltyrosyl-isoleucyl-glutaminyl-asparaginyl-S-(β-carboxyethyl)homocysteinyl-prolyl-leucyl-glycine amide 
• 77730-81-5 <2-O-ethyltyrosine>deamino-6-carba-oxytocin 
• 85676-28-4 Boc-Tyr(Et)-Arg-OMe_.CH₃COOH 
• 85675-84-9 C.<-Tyr(Et)-Arg->.CH3COOH 
• 85676-06-8 C_.(-Tyr(Et)-Har-).CH₃COOH 
• 85676-40-0 H-Tyr(Et)-Har-OMe_.2HCl 
• 88718-86-9 Boc-Tyr(Et)-Har-OMe 
• 82057-60-1 (S)-3-(4-Ethoxy-phenyl)-2-(2-nitro-phenylsulfanylamino)-propionic acid 
• 76757-91-0 N-tert-butoxycarbonyl-O-ethyl-L-tyrosine 

Relevant articles and documents

Preparation method of L-tyrosine derivative

The invention discloses a preparation method of an L-tyrosine derivative. The L-tyrosine derivative is O-alkyl-N-[fluorenylmethoxycarbonyl]-L-tyrosine, L-tyrosine is used as a starting material, the O-alkyl-N-[fluorenylmethoxycarbonyl]-L-tyrosine is prepared through esterification, amidation, etherification/hydrolysis and amidation in sequence, the total yield of the target product can reach 61.5%, and the ee value can reach 99% or above. The preparation method disclosed by the invention has the advantages of cheap and easily available raw materials, lower cost and the like, for example, separation of triphenylphosphine oxide is avoided through etherification reaction. The method has the advantages of simple process, short route, mild reaction conditions and the like, for example, etherification and hydrolysis adopt a one-pot method; and the whole technological process generates few three wastes, the product yield and purity are high, and the method is suitable for industrial production.

Studies on analgesic oligopeptides. II. Structure-activity relationship among thirty analogs of a cyclic dipeptide, cyclo(-Tyr-Arg-)

Thirty diketopiperazines were synthesized as analogs of cyclo(-Tyr-Arg-). The analgesic activities of these analogs were evaluated after intracerebral administration in mice. In the cyclo(-X-Arg-) series of analogs, cyclo[-Tyr(Et)-Arg-] showed the most po