329195-68-8

Basic information

• Product Name: 2-[4-(methylsulfanyl)phenyl]-2,3-dihydro-4(1H)-quinazolinone
• Synonyms: 2-[4-(methylsulfanyl)phenyl]-2,3-dihydro-4(1H)-quinazolinone
• CAS NO: 329195-68-8
• Molecular Formula: C₁₅H₁₄N₂OS
• Molecular Weight: 270.34946
• Mol File: 329195-68-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-[4-(methylsulfanyl)phenyl]-2,3-dihydro-4(1H)-quinazolinone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[4-(methylsulfanyl)phenyl]-2,3-dihydro-4(1H)-quinazolinone(329195-68-8)
• EPA Substance Registry System: 2-[4-(methylsulfanyl)phenyl]-2,3-dihydro-4(1H)-quinazolinone(329195-68-8)

Safety Data

• Hazardous Substances Data: 329195-68-8(Hazardous Substances Data)

Upstream product

• 28144-70-9 anthranilic acid amide 
• 3446-89-7 4-(Methylthio)benzaldehyde 

Relevant articles and documents

Organocatalysis by p-sulfonic acid calix[4]arene: A convenient and efficient route to 2,3-dihydroquinazolin-4(1H)-ones in water

An efficient and eco-friendly method is reported for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones from the direct cyclocondensation of anthranilamide with aldehydes using p-sulfonic acid calix[4]arene (p-SAC) as a recyclable organocatalyst in excellent yields in water at room temperature. The catalyst was reusable without significant loss of catalytic efficiency. Operational simplicity, the compatibility with various functional groups, non-chromatographic purification technique, high yields and mild reaction conditions are the notable advantages of this procedure. Large scale reaction demonstrated the practical applicability of this methodology.

Cyanuric chloride catalyzed mild protocol for synthesis of biologically active dihydro/spiro quinazolinones and quinazolinone-glycoconjugates

We have developed an efficient cyanuric chloride (2,4,6-trichloro-1,3,5- triazine, TCT) catalyzed approach for the synthesis of 2,3-dihydroquinazolin- 4(1H)-one (3a-3x), 2-spiroquinazolinone (5, 7), and glycoconjugates of 2,3-dihydroquinazolin-4(1H)-one (10a, 10b) derivatives. The reaction allows rapid cyclization (8-20 min) with 10 mol % cyanuric chloride to give skeletal complexity in good to excellent yield. We believe that this novel procedure may open the door for the easy generation of new and bioactive quinazolinones.