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Cas Database

33036-33-8

33036-33-8

Identification

  • Product Name:Estran-17-one,3-hydroxy-, (3a,5b)-

  • CAS Number: 33036-33-8

  • EINECS:

  • Molecular Weight:276.41

  • Molecular Formula: C18H28 O2

  • HS Code:

  • Mol File:33036-33-8.mol

Synonyms:5b-Estran-17-one, 3a-hydroxy- (8CI);19-Noretiocholan-3a-ol-17-one; 19-Noretiocholanolone; 3a-Hydroxy-5b-estran-17-one; 5b-Estran-3a-ol-17-one

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Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:Cayman Chemical
  • Product Description:19-Noretiocholanolone ≥98%
  • Packaging:25mg
  • Price:$ 134
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Cayman Chemical
  • Product Description:19-Noretiocholanolone ≥98%
  • Packaging:10mg
  • Price:$ 96
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Cayman Chemical
  • Product Description:19-Noretiocholanolone ≥98%
  • Packaging:5mg
  • Price:$ 54
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:AK Scientific
  • Product Description:19-Noretiocholanolone
  • Packaging:25mg
  • Price:$ 266
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:AK Scientific
  • Product Description:19-Noretiocholanolone
  • Packaging:10mg
  • Price:$ 218
  • Delivery:In stock
  • Buy Now

Relevant articles and documentsAll total 3 Articles be found

NEUROACTIVE STEROIDS AND COMPOSITIONS THEREOF

-

Paragraph 0627, (2020/12/11)

Provided herein is a compound of Formula (I) or a pharmaceutically acceptable salt thereof, wherein R1a, R1b, R2a, R2b, R3, R4a, R4b, R5, R6a, R6b, R7a, R7a, R11a, R11b, R12a, R12b, R16a, R16b, R19, R11a, R22, RX, RY and n are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) and methods of using the compounds, e.g., in the treatment of CNS-related disorders.

Preparation of neuroactive steroids of the androstane and pregnane series.

-

, (2008/06/13)

-

Microbiological Transformations. XVI. Transformation of 5α- and 5β-Dihydro, and 1- and 6-Dehydro Derivatives of Testosterone and Androstenedione by Means of Rhodotorula mucilaginosa Strain

Draczynska, Bozena,Tlomak, Elzbieta,Dmochowska-Gladysz, Jadwiga,Siewinski, Antoni

, p. 13 - 21 (2007/10/02)

The following transformation of 5α- and 5β-dihydro derivatives of testosterone and androstenedione by means of Rhodotorula mucilaginosa has been observed: reduction of the carbonyl group on C-3 to both possible alcohols in the 5α-series and only to one alcohol (3α) in the 5β-series.In the transformation of 1- and 6-dehydro derivatives of testosterone and androstenedione, reduction in ring A was completely inhibited.The carbonyl or hydroxy groups at C-17 in both series of substrates underwent interconversion.

Process route upstream and downstream products

Process route

17β-hydroxy-19-nor-5β-androstan-3-one
19468-31-6

17β-hydroxy-19-nor-5β-androstan-3-one

5β‐estrane‐3α,17β‐diol
10002-97-8

5β‐estrane‐3α,17β‐diol

3α-hydroxy-19-nor-5β-androstan-17-one
33036-33-8

3α-hydroxy-19-nor-5β-androstan-17-one

5β-estrane-3,17-dione
5696-51-5

5β-estrane-3,17-dione

Conditions
Conditions Yield
for 504h; Rhodotorula mucilaginosa;
3%
9%
80%
5β-estrane-3,17-dione
5696-51-5

5β-estrane-3,17-dione

3α-hydroxy-19-nor-5β-androstan-17-one
33036-33-8

3α-hydroxy-19-nor-5β-androstan-17-one

Conditions
Conditions Yield
With lithium tri-t-butoxyaluminum hydride; In tetrahydrofuran; at -40 ℃; for 2.5h; Inert atmosphere;
13.92 g
5β-estrane-3,17-dione
5696-51-5

5β-estrane-3,17-dione

lithium tri-(tert-butoxy)aluminum hydride

lithium tri-(tert-butoxy)aluminum hydride

3α-hydroxy-19-nor-5β-androstan-17-one
33036-33-8

3α-hydroxy-19-nor-5β-androstan-17-one

Conditions
Conditions Yield
In tetrahydrofuran;
Conditions
Conditions Yield
3β,17β-Dihydroxy-19-nor-5α-androstan, Digitonin/A., dann CrO3/HOAc; Py.;
Conditions
Conditions Yield
19-Nor-androstandion-(3,17), NaBH4/wss.i-PrOH/Me. (neben 19-Nor-androstandiol-(3β,17β));
5α-Oestrandion-(3,17)/A., Raney-Ni/Me.(Kochen), (neben 5α-Oestranol-(3α)-on-(17));
Conditions
Conditions Yield
entspr. 3β-Tosylat/DMF (80-85grad), dann wss.KOH/Me.<Δ> (neben 19-Nor-Δ2-androstenon-(17));
5α-Oestrandion-(3,17)/A., Raney-Ni/Me.(Kochen), (neben 5α-Oestranol-(3β)-on-(17));
Conditions
Conditions Yield
5β-Oestrandion-(3,17)/A., Raney-Ni (Kochen), (neben 5β-Oestranol-(3β)-on-(17));
Conditions
Conditions Yield
5β-Oestrandion-(3,17)/A., Raney-Ni (Kochen), (neben 5β-Oestranol-(3α)-on-(17));
Conditions
Conditions Yield
19-Nor-5α-androst-3-en-17-on-ethylenketal, B2H6/THF; KOH/Me./H2O2;
Conditions
Conditions Yield
5α,10α-Oestrandiol-(3α,17β)-acetat-(17), TosOH*H2O/Dihydropyran/Bzl.; Kochen m. NaOH/Me./W.; CrO3-Reagenz/Acn.; TosOH*H2O/Me.;

Global suppliers and manufacturers

Global( 1) Suppliers
  • Company Name
  • Business Type
  • Contact Tel
  • Emails
  • Main Products
  • Country
  • NovaChemistry
  • Business Type:Trading Company
  • Contact Tel:+44 (0)208 191 7890
  • Emails:info@novachemistry.com
  • Main Products:1
  • Country:United Kingdom
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