3339-11-5

Basic information

• Product Name: tolpropamine hydrochloride
• Synonyms: tolpropamine hydrochloride;Einecs 222-082-9;Tolpropamine HCl
• CAS NO: 3339-11-5
• Molecular Formula: C₁₈H₂₃N*ClH
• Molecular Weight: 0
• EINECS: 222-082-9
• Mol File: 3339-11-5.mol

Chemical Properties

• Boiling Point: 359.8°Cat760mmHg
• Flash Point: 154.7°C
• Appearance: /
• Density: 0.977g/cm³
• Vapor Pressure: 2.33E-05mmHg at 25°C
• CAS DataBase Reference: tolpropamine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: tolpropamine hydrochloride(3339-11-5)
• EPA Substance Registry System: tolpropamine hydrochloride(3339-11-5)

Safety Data

• Hazardous Substances Data: 3339-11-5(Hazardous Substances Data)

Usage

Originator

Tolpropamine,Hoechst (Aventis)

Manufacturing Process

The Grignard solution (prepared from 53 g bromtoluene and 7.2 g magnesium in 300 ml of ether) was added dropwise to a solution of 35 g β- dimethylaminopropiophenone in 50 ml ether. The mixture was refluxed for 3 hours. Then the liquid phase was added to 500 parts of ice and 100 parts concentrated hydrochloric acid. 1-Phenyl-1-p-tolyl-3-dimethylaminopropanol-1 was crystallized. M.P. of hydrochloride of 1-phenyl-1-p-tolyl-3- dimethylaminopropanol-1 185°C. 10 g of 1-phenyl-1-p-tolyl-3-dimethylaminopropanol-1 was dissolved in 30 ml of 85% phosphoric acid and the solution was heated at 130-135°C for 1 hour. After cooling to the mixture was added a water and an aqueous solution of sodium hydroxide. γ-Phenyl-γ-p-tolylallyldimethylamine was extracted with ether and extract was dried with sodium sulfate. γ-Phenyl-γ-p-tolylallyldimethylamine hydrochloride was hydrogenated with palladium catalyst. γ-Phenyl-γ-p-tolyl-3-dimethylaminopropan obtained has melting point 156°C.

InChI:InChI=1/C18H23N.ClH/c1-15-9-11-17(12-10-15)18(13-14-19(2)3)16-7-5-4-6-8-16;/h4-12,18H,13-14H2,1-3H3;1H