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33527-94-5

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33527-94-5 Usage

General Description

4-Iodophenylacetate is a chemical compound that consists of a phenyl ring with an iodine substitution at the para position and an acetate group attached to the benzene ring. It is commonly used as an intermediate in the synthesis of pharmaceuticals and organic compounds. This chemical has various applications in organic chemistry, such as in the preparation of esters, amides, and other organic compounds. It is an important building block for the synthesis of biologically active molecules and has been studied for its potential pharmacological properties. Its structure and reactivity make it a versatile compound for use in organic synthesis and drug development.

Check Digit Verification of cas no

The CAS Registry Mumber 33527-94-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,3,5,2 and 7 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 33527-94:
(7*3)+(6*3)+(5*5)+(4*2)+(3*7)+(2*9)+(1*4)=115
115 % 10 = 5
So 33527-94-5 is a valid CAS Registry Number.
InChI:InChI=1/C8H7IO2/c1-6(10)11-8-4-2-7(9)3-5-8/h2-5H,1H3

33527-94-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-iodo-Phenol, acetate

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:33527-94-5 SDS

33527-94-5Relevant articles and documents

Steric effect of NHC ligands in Pd(II)–NHC-catalyzed non-directed C–H acetoxylation of simple arenes

Mandal, Tanmoy,Yadav, Sudha,Choudhury, Joyanta

, (2021/09/06)

Although there has been a lot of progress in oxidative arene C–H functionalization reactions catalyzed by Pd(II/IV) system, the non-directed, site-selective functionalization of arene molecules is still challenging. It has been established that ligands play a pivotal role in controlling rate- as well as selectivity-determining step in a catalytic cycle involving well-defined metal-ligand bonding. N-heterocyclic carbene (NHC) ligands have had a tremendous contribution in the recent extraordinary success of achieving high reactivity and excellent selectivity in many catalytic processes including cross-coupling and olefin-metathesis reactions. However, the immense potential of these NHC ligands in improving site-selectivity of non-directed catalytic C–H functionalization reactions of simple arenes is yet to be realized, where overriding the electronic bias on deciding selectivity is a burdensome task. The presented work demonstrated an initiative step in this regard. Herein, a series of well-defined discrete [Pd(NHCR′R)(py)I2] complexes with systematically varied degree of spatial congestion at the Pd centre, exerted through the R and R’ substituents on the NHC ligand, were explored in controlling the activity as well as the site-selectivity of non-directed acetoxylation of representative monosubstituted and disubstituted simple arenes (such as toluene, iodobenzene and bromobenzene, naphthalene and 1,2-dichlorobenzene). The resulting best yields were found to be 75% for toluene and 65% for bromobenzene with [Pd(NHCMePh)(py)I2], 75% for iodobenzene and 79% for naphthalene with [Pd(NHCMeMe)(py)I2], and 41% for 1,2-dichlorobenzene with [Pd(NHCCyCy)(py)I2]. Most importantly, with increasing the bulkiness of the NHC ligand in the complexes, the selectivity of the distal C-acetoxylated products in comparison to the proximal ones, was enhanced to a great extent in all cases. Considering the vast library of NHC ligands, this study underscores the future opportunity to develop more strategies to improve the activity and the crucial site-selectivity of C–H functionalization reactions in simple as well as complex organic molecules.

Development of an Enzyme-Inhibitor Reaction Using Cellular Retinoic Acid Binding Protein II for One-Pot Megamolecule Assembly

Kimmel, Blaise R.,Mrksich, Milan

supporting information, p. 17843 - 17848 (2021/11/22)

This paper presents an enzyme building block for the assembly of megamolecules. The system is based on the inhibition of the human-derived cellular retinoic acid binding protein II (CRABP2) domain. We synthesized a synthetic retinoid bearing an arylfluoro

Acyl-based donor molecules

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Paragraph 0077, (2021/12/07)

Problem: To provide acyl-based donor molecules that enable acylization of the target molecule at high efficiency and acylizing agents using the molecule as an active ingredient.Solution: Compounds having the following structure and acylated agents using the compound as an active ingredient.【Chemical 1】(R indicates acyl group, X indicates hydrophilic group)【Selection diagram】 None

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