33630-99-8

Basic information

• Product Name: 3-Amino-2-pyridinol
• Synonyms: 2-HYDROXY-3-AMINO PYRIDINE;3-AMINO-PYRIDIN-2-OL;3-AMINO-2-HYDROXYPYRIDINE 99%;3-Amino-2(1H)-pyridinone;3-Amino-2-hydroxypyridine;3-Amino-2-pyridinol;3-Amino-2-hydroxypyridine ,98%;3-Amino-2-pyridinol,97%
• CAS NO: 33630-99-8
• Molecular Formula: C₅H₆N₂O
• Molecular Weight: 110.11
• Product Categories: Pyridine;Pyridine Series;pharmacetical;Amines;Pyridines
• Mol File: 33630-99-8.mol
• Article Data: 31

Chemical Properties

• Melting Point: 118-130 °C
• Boiling Point: 206.4°C (rough estimate)
• Flash Point: 170.7 °C
• Appearance: Dark brown to black/Powder
• Density: 1.2111 (rough estimate)
• Vapor Pressure: 2.5E-05mmHg at 25°C
• Refractive Index: 1.4800 (estimate)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 13.87±0.10(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 3-Amino-2-pyridinol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Amino-2-pyridinol(33630-99-8)
• EPA Substance Registry System: 3-Amino-2-pyridinol(33630-99-8)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 37/39-26-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 33630-99-8(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 33630-99-8 differently. You can refer to the following data:
1. 3-Amino-2-hydroxypyridine has been used as a reactant in the preparation of benzothiazolyl hydroxyindolinylphenyl ureas as potent P2Y1 antagonists.
2. It is used as pharmaceutical intermediate. It is involved in synthesis of functionalized pyrido[4,3-b][1,4]oxazine and imidazo[1,2-a]pyridine derivatives. The use of ethyl 2-chloro-3-oxopropanoate with 2-amino-3-hydroxypyridine or 3-amino-4-hydroxypyridine led, respectively, to imidazo[1,2-a]pyridine derivatives or ethyl pyrido[4,3-b][1,4] oxazine-2-carboxylate.

Chemical Properties

Brown to off-white crystalline powder.

InChI:InChI=1/C5H6N2O/c6-4-2-1-3-7-5(4)8/h1-3H,6H2,(H,7,8)

Upstream product

• 118767-92-3 oxazolo[5,4-b]pyridin-2(3H)-one 
• 4214-75-9 2-amino-3-nitropyridine 
• 92138-35-7 6-chloro-3-nitro-1H-pyridin-2-one 
• 56-40-6 glycine 
• 1462-86-8 3-amino-pyridine-2-carboxylic acid 
• 142-08-5 2-Pyridone 
• 6332-56-5 3-nitropyridone 
• 15010-23-8 3-acetamidopyridine N-oxide 
• 16867-04-2 dihydroxypyridine 
• 98786-86-8 5-bromo-2-hydroxy-3-aminopyridine 
• 142-08-5 2-hydroxypyridin 
• 165547-79-5 2-hydroxy-3-nitro-4-chloropyridine 
• 6332-56-5 2-hydroxy-3-nitropyridine 

Downstream Products

• 88972-92-3 2,6-Di-tert-butyl-4-oxazolo[5,4-b]pyridin-2-yl-phenol 
• 118767-92-3 oxazolo[5,4-b]pyridin-2(3H)-one 
• 131073-17-1 2-(2-methoxy-4-methylthiophenyl)oxazolo<5,4-b>pyridine 
• 67967-11-7 8-hydroxy-1,7-naphthyridine 
• 76349-07-0 N-(2-hydroxypyridin-3-yl)acetamide 
• 118487-95-9 5-hydroxy-4-[(3,5-dimethoxyphenyl)ureylene]-7-methylthieno[2,3-c]pyridine 
• 942589-77-7 4-bromo-N-(2-oxo-1,2-dihydro-3-pyridinyl)benzamide 
• 33631-21-9 3-amino-2H-pyridin-2-one hydrochloride 
• 136742-83-1 1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one 
• 52334-52-8 3-(2-fluoro-benzoylamino)-1H-pyridin-2-one 

Relevant articles and documents

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Synthesis and applications of 3-amino-2-hydroxypyridine

The invention discloses synthesis and applications of 3-amino-2-hydroxypyridine. The synthesis steps comprise: (1) dissolving 2-hydroxy-3-nitro-5-bromopyridine in a solvent, stirring, adding the mixture of iron powder and hydrochloric acid, carrying out a reaction for 0.5-1 h, and carrying out post-treatment to obtain 2-hydroxy-3-amino-5-bromopyridine; and (2) dissolving the 2-hydroxy-3-amino-5-bromopyridine obtained in the step (1) in an alkaline solution, adding strontium carbonate, introducing hydrogen into a reaction bottle, carrying out a reaction for a certain time, and carrying out conventional treatment to obtain 3-amino-2-hydroxypyridine. According to the present invention, the production cost is substantially reduced, and the obtained 3-amino-2-hydroxypyridine has the high purityand can be directly used in the next step.