3367-48-4

Basic information

• Product Name: 1,4-bis(4-methylphenyl)piperazine
• CAS NO: 3367-48-4
• Molecular Formula: C₁₈H₂₂N₂
• Molecular Weight: 266.3807
• Mol File: 3367-48-4.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 441.6°C at 760 mmHg
• Flash Point: 201.4°C
• Density: 1.067g/cm³
• Vapor Pressure: 5.39E-08mmHg at 25°C
• Refractive Index: 1.589
• CAS DataBase Reference: 1,4-bis(4-methylphenyl)piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-bis(4-methylphenyl)piperazine(3367-48-4)
• EPA Substance Registry System: 1,4-bis(4-methylphenyl)piperazine(3367-48-4)

Safety Data

• Hazardous Substances Data: 3367-48-4(Hazardous Substances Data)

Usage

General Description

1,4-bis(4-methylphenyl)piperazine, also known as BPP, is a chemical compound that belongs to the piperazine class of chemicals. It is a derivative of piperazine and consists of a piperazine ring with two 4-methylphenyl groups attached to it. BPP has been studied for its potential use in pharmaceuticals, particularly as a central nervous system stimulant. It has also been investigated for its potential use as a drug precursor. BPP has been found to have stimulant effects on the central nervous system, and its potential use in pharmaceuticals and as a precursor to other chemicals makes it an important compound for further research and exploration.

Upstream product

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Relevant articles and documents

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β-Amino alcohols from anilines and ethylene glycol through heterogeneous Borrowing Hydrogen reaction

Borrowing Hydrogen (BH), also called Hydrogen Autotransfer (HA), reaction with neat ethylene glycol represents a key step in the preparation of β-amino alcohols. However, due to the stability of ethylene glycol, mono-activation has rarely been achieved. Herein, a combination of Pd/C and ZnO is reported as heterogeneous catalyst for this BH/HA reaction. This system results in an extremely air and moisture stable, and economic catalyst able to mono-functionalize ethylene glycol in water, without further activation of the diol. In this work, different diols and aromatic amines have been explored affording a new approach towards amino alcohols. This study reveals how the combination of two solid species can afford interesting catalytic properties in heterogeneous phase. ZnO activates ethylene glycol while Pd/C is the responsible of the BH/HA cycle. This catalytic system has also been found useful to dehydrogenate indoles affording indolines that undergo in situ BH/HA cycle prior to re-aromatization, representing a tandem heterogeneous process.

Microwave-promoted mono-N-alkylation of aromatic amines in water: A new efficient and green method for an old and problematic reaction

A greener improvement to direct mono-N-alkylation of aromatic amines by alkyl halides was achieved using microwave irradiation in water without any catalyst.