33766-31-3

Basic information

• Product Name: NEOTHUJOL
• Synonyms: NEOTHUJOL;(+)-3-Isothujanol;(1R,5β)-4β-Methyl-1β-isopropylbicyclo[3.1.0]hexan-3α-ol
• CAS NO: 33766-31-3
• Molecular Formula: C₁₀H₁₈O
• Molecular Weight: 154.24932
• Mol File: 33766-31-3.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: NEOTHUJOL(CAS DataBase Reference)
• NIST Chemistry Reference: NEOTHUJOL(33766-31-3)
• EPA Substance Registry System: NEOTHUJOL(33766-31-3)

Safety Data

• Hazardous Substances Data: 33766-31-3(Hazardous Substances Data)

Upstream product

• 59503-88-7 (+/-)-3-Isothujanol-p-nitrobenzoat 
• 7788-93-4 (-)-Isothujanol-p-toluolsulfonat 

Relevant articles and documents

(-) 3 Isothujone, a small nonnitrogenous molecule with antinociceptive activity in mice

(-) 3 isothujone and (+) 3 thujone were examined for antinociceptive activity using the hot plate and Nilsen tests. In the hot plate test (-) 3 isothujone (ED50 = 6.5 mg/kg) was found to be codeine like and equipotent with (-) Δ9 tetrahydrocannabinol while the racemic material was essentially half as potent as the levorotatory isomer. (+) 3 Thyjone was inactive in both antinociceptive tests as were several structural analogues of the 3 thujones. As with the THC's less antinociceptive activity was observed in the Nilsen test than in the hot plate assay. Acute toxicities for the 3 thujones were determined and vastly improved synthetic procedures have been developed for two long known but difficultly accessible 3 thujanols.