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4-(4-Bromo-2-fluorobenzyl)morpholine is a chemical compound characterized by a morpholine ring with a 4-(4-bromo-2-fluorophenyl) group attached to it. It is known for its versatile reactivity and potential biological activity, making it a valuable component in the synthesis of pharmaceutical and agrochemical products.

338454-98-1

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338454-98-1 Usage

Uses

Used in Pharmaceutical Industry:
4-(4-Bromo-2-fluorobenzyl)morpholine is used as a building block for the synthesis of various pharmaceutical products due to its potential antiviral, antifungal, and antibacterial properties. Its unique structure allows it to be incorporated into the development of new drugs with enhanced therapeutic effects.
Used in Agrochemical Industry:
In the agrochemical industry, 4-(4-Bromo-2-fluorobenzyl)morpholine is utilized as a key component in the creation of agrochemical products. Its potential biological activity contributes to the development of effective pesticides and other agricultural chemicals.
Used in Metal-Catalyzed Reactions:
4-(4-Bromo-2-fluorobenzyl)morpholine is employed as a ligand in metal-catalyzed reactions. Its presence can enhance the efficiency and selectivity of these reactions, leading to improved synthetic routes and the production of desired compounds.
Used in Organic Synthesis:
As a precursor in organic synthesis, 4-(4-Bromo-2-fluorobenzyl)morpholine plays a crucial role in the formation of complex organic molecules. Its reactivity and structural features enable the synthesis of a wide range of compounds with diverse applications in various industries.

Check Digit Verification of cas no

The CAS Registry Mumber 338454-98-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,3,8,4,5 and 4 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 338454-98:
(8*3)+(7*3)+(6*8)+(5*4)+(4*5)+(3*4)+(2*9)+(1*8)=171
171 % 10 = 1
So 338454-98-1 is a valid CAS Registry Number.

338454-98-1 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
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  • Detail
  • Alfa Aesar

  • (H62716)  4-(4-Bromo-2-fluorobenzyl)morpholine, 96%   

  • 338454-98-1

  • 250mg

  • 504.0CNY

  • Detail
  • Alfa Aesar

  • (H62716)  4-(4-Bromo-2-fluorobenzyl)morpholine, 96%   

  • 338454-98-1

  • 1g

  • 1511.0CNY

  • Detail
  • Alfa Aesar

  • (H62716)  4-(4-Bromo-2-fluorobenzyl)morpholine, 96%   

  • 338454-98-1

  • 5g

  • 6036.0CNY

  • Detail

338454-98-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-[(4-bromo-2-fluorophenyl)methyl]morpholine

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:338454-98-1 SDS

338454-98-1Relevant articles and documents

TRICYCLIC DEGRADERS OF IKAROS AND AIOLOS

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Page/Page column 656-657, (2020/10/21)

Tricyclic cereblon binders for the degradation of Ikaros or Aiolos by the ubiquitin proteasome pathway for therapeutic applications are described.

Novel Triazolopyrazine Derivatives and Use Thereof

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, (2017/07/31)

The present invention relates to novel triazolopyrazine derivatives or a pharmaceutically acceptable salt, and a pharmaceutical composition for inhibiting c-Met tyrosine kinase activity and a pharmaceutical composition for preventing or treating hyperproliferative disorders, containing the same as active ingredients. The present invention effectively inhibits c-Met tyrosine kinase activity, thereby being able to be useful as a drug for various hyperproliferative disorders such as cancers, psoriasis, rheumatoid arthritis, diabetic retinitis, etc. related to excessive cell proliferation and growth by abnormal kinase activation.

Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy

Baragana, Beatriz,Norcross, Neil R.,Wilson, Caroline,Porzelle, Achim,Hallyburton, Irene,Grimaldi, Raffaella,Osuna-Cabello, Maria,Norval, Suzanne,Riley, Jennifer,Stojanovski, Laste,Simeons, Frederick R. C.,Wyatt, Paul G.,Delves, Michael J.,Meister, Stephan,Duffy, Sandra,Avery, Vicky M.,Winzeler, Elizabeth A.,Sinden, Robert E.,Wittlin, Sergio,Frearson, Julie A.,Gray, David W.,Fairlamb, Alan H.,Waterson, David,Campbell, Simon F.,Willis, Paul,Read, Kevin D.,Gilbert, Ian H.

supporting information, p. 9672 - 9685 (2016/11/19)

The antiplasmodial activity, DMPK properties, and efficacy of a series of quinoline-4-carboxamides are described. This series was identified from a phenotypic screen against the blood stage of Plasmodium falciparum (3D7) and displayed moderate potency but with suboptimal physicochemical properties and poor microsomal stability. The screening hit (1, EC50 = 120 nM) was optimized to lead molecules with low nanomolar in vitro potency. Improvement of the pharmacokinetic profile led to several compounds showing excellent oral efficacy in the P. berghei malaria mouse model with ED90 values below 1 mg/kg when dosed orally for 4 days. The favorable potency, selectivity, DMPK properties, and efficacy coupled with a novel mechanism of action, inhibition of translation elongation factor 2 (PfEF2), led to progression of 2 (DDD107498) to preclinical development.

NOVEL TRIAZOLOPYRAZINE DERIVATIVE AND USE THEREOF

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, (2015/10/06)

The present invention relates to a novel triazolopyrazine derivative or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the same as an active ingredient for preventing or treating hyper proliferative disorder. The present invention can be useful as a therapeutic agent for various hyper proliferative disorders associated with excessive cell proliferation and growth caused by abnormal kinase activity, such as cancer, psoriasis, rheumatoid arthritis, and diabetic retinopathy, by efficiently inhibiting c-Met tyrosine kinase activity.

Anti-Malarial Agents

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Paragraph 0332-0335, (2015/02/25)

The present invention relates to a novel class of quinolone-4-carboxamide Pf3D7 inhibitors of general formula (I) (Formula (I)) wherein R1, R2, R3, R4, R5, R6, R7, R8 and X are as defined herein, to their use in medicine, and in the treatment of malaria in particular, to compositions containing them, to processes for their preparation and to intermediates used in such processes.

ANTI-MALARIAL AGENTS

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Page/Page column 54; 55, (2013/11/05)

The present invention relates to a novel class of quinolone-4-carboxamide Pf3D7 inhibitors of general formula (I) (Formula (I)) wherein R1, R2, R3, R4, R5, R6, R7, R8 and X are as defined herein, to their use in medicine, and in the treatment of malaria in particular, to compositions containing them, to processes for their preparation and to intermediates used in such processes.

[1, 2, 4] TRIAZOLO [1, 5-A] PYRIDINES AS JAK INHIBITORS

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Page/Page column 64, (2010/04/03)

Novel [1,2,4]triazolo[1,5-a]pyridine compounds are disclosed that have a Formula represented by the following: (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, joint disease, inflammation, and others.

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