33933-80-1Relevant articles and documents
Triflimide-catalysed sigmatropic rearrangement of N-allylhydrazones as an example of a traceless bond construction
Mundal, Devon A.,Avetta Jr., Christopher T.,Thomson, Regan J.
supporting information; experimental part, p. 294 - 297 (2010/09/12)
The recognition of structural elements (that is, retrons) that signal the application of specific chemical transformations is a key cognitive event in the design of synthetic routes to complex molecules. Reactions that produce compounds without an easily identifiable retron, by way of either substantial structural rearrangement or loss of the atoms required for the reaction to proceed, are significantly more difficult to apply during retrosynthetic planning, yet allow for non-traditional pathways that may facilitate efficient acquisition of the target molecule. We have developed a triflimide (Tf 2 NH)-catalysed rearrangement of N-allylhydrazones that allows for the generation of a sigma bond between two unfunctionalized sp 3 carbons in such a way that no clear retron for the reaction remains. This new traceless bond construction displays a broad substrate profile and should open avenues for synthesizing complex molecules using non-traditional disconnections.
SPECIFIC BRANCHED ALDEHYDES, ALCOHOLS, SURFACTANTS AND CONSUMER PRODUCTS BASED THEREON
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Page/Page column 14-16, (2010/04/25)
A process for preparing a detergent alcohol mixture comprising the steps of providing one or more poly-branched poly-olefins, wherein the poly-branched poly-olefins must contain one non-branched terminal olefin and one or more additional branched olefins in the molecule; hydroformylating said poly-branched poly-olefins to produce a poly-branched olefin containing aldehyde product with one or more olefins or mixture thereof; reducing the aldehyde product of step (b) in the presence of hydrogen and a hydrogenation catalyst to form a poly-branched detergent alcohol mixture; and removing said poly-branched alcohol mixture from said catalyst and branched aldehydes, alcohols and surfactants produced from the products of this process.
Insect Moulting Hormones. LV. Experiments Directed Towards the Synthesis of Non-steroidal Ecdysone Analogues
Bergamasco, Rinaldo,Horn, Denis H. S.,Nearn, Roland H.,Wilkie, John S.
, p. 475 - 483 (2007/10/02)
Exploratory studies aimed at the synthesis of the non-steroidal ecdysone analogue (4aR,7S,8aR,1'RS,4'R)-7-hydroxy-3-(1'-hydroxy-4',8'-dimethylnonyl)-4a-methyl-4a,5,6,7,8,8a-hexahydronaphthalen-1(4H)-one (3) have led to an efficient method of joining the c
