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34017-15-7

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34017-15-7 Usage

Chemical Properties

White Solid

Uses

Different sources of media describe the Uses of 34017-15-7 differently. You can refer to the following data:
1. The major metabolite of Probenecid (P755000).
2. The major metabolite of Probenecid.

Check Digit Verification of cas no

The CAS Registry Mumber 34017-15-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,4,0,1 and 7 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 34017-15:
(7*3)+(6*4)+(5*0)+(4*1)+(3*7)+(2*1)+(1*5)=77
77 % 10 = 7
So 34017-15-7 is a valid CAS Registry Number.
InChI:InChI=1/C19H27NO10S/c1-3-9-20(10-4-2)31(27,28)12-7-5-11(6-8-12)18(26)30-19-15(23)13(21)14(22)16(29-19)17(24)25/h5-8,13-16,19,21-23H,3-4,9-10H2,1-2H3,(H,24,25)/t13-,14-,15+,16-,19-/m0/s1

34017-15-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name Probenecid Acyl β-D-Glucuronide

1.2 Other means of identification

Product number -
Other names 1-[p-(Dipropylsulfamoyl)benzoate]-D-Glucopyranuronic Acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:34017-15-7 SDS

34017-15-7Upstream product

34017-15-7Relevant articles and documents

Rapid internal acyl migration and protein binding of synthetic probenecid glucuronides

Akira, Kazuki,Uchijima, Takafumi,Hashimoto, Takao

, p. 765 - 772 (2002)

Internal acyl migration reactions of drug 1-O-acyl-β-D-glucopyranuronates (1β-acyl glucuronides) are of interest because of their possible role in covalent binding to proteins and consequent adverse effects. The reactivity of the synthetic probenecid 1β-acyl glucuronide (PRG), the principal metabolite of probenecid (PR) in humans, has been investigated in terms of acyl migration, hydrolysis, and covalent binding to proteins in phosphate buffer (pH 7.4) and human plasma at 37 °C. PRG primarily degraded by acyl migration according to apparent first-order kinetics and the 2-, 3-, and 4-acyl isomers sequentially appeared as both α- and β-anomeric forms. In addition, small amounts of PRG and extremely labile 1α-acyl isomer existed in the equilibrated mixture favoring the 2α/β-acyl isomer, that provided significant information regarding the mechanism of acyl migration. All of the positional isomers and anomers were characterized using preparative HPLC and NMR spectroscopy. Acyl migration was observed to predominate over hydrolysis in both media although the extent of hydrolysis in plasma was larger than that in the buffer. The overall degradation half-lives (h) in the buffer and plasma were 0.27 ± 0.003 and 0.17 ± 0.007, respectively. The covalent binding rapidly proceeded mainly via the Schiff's base mechanism and reached a plateau after 2 h of incubation. The maximal binding was 146 ± 4.8 pmol/mg of protein, and ca. 10% of the initial concentration of PRG. These results indicated that PRG is most labile and susceptible to acyl migration of all the drug acyl glucuronides reported to date in the physiological conditions, and highly reactive to plasma proteins, that could provide a possible explanation for the immunologically based adverse effects of PR.

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