3411-95-8Relevant articles and documents
Developing a novel ratiometric fluorescent probe based on ESIPT for the detection of pH changes in living cells
Song, Wenhui,Dong, Baoli,Lu, Yaru,Lin, Weiying
, p. 1696 - 1701 (2019)
As an important parameter of intracellular metabolism, pH plays important roles in maintaining normal physiological processes. The abnormal pH could cause disorder of cell function which may cause neurological diseases. Herein, we present two novel ratiometric fluorescent probes to detect pH changes. The probes employed 2-(2′-hydroxyphenyl)benzothiazole as fluorescent platform, and displayed desirable fluorescence response to pH on the basis of excited state intramolecular proton transfer (ESIPT) process. The probe BtyC-1 showed green fluorescence at 546 nm under acidic conditions, while it displayed strong blue fluorescence at 473 nm and weak green fluorescence at 546 nm under alkaline conditions. Biological experiments demonstrated that the probe BtyC-1 could be successfully applied for the ratiometric imaging of cellular pH and the NH4Cl-induced pH changes in living cells.
Observation of the generation of peroxynitrite in mouse liver after acetaminophen overdose with a boronate-based ratiometric fluorescence probe
Ma, Ying,Tian, Haigang,Jin, Zhengyu,Li, Xiaoyong,Li, Yiping
, p. 6510 - 6514 (2019)
A ratiometric fluorescent probe, BTPB, for the selective monitoring of hepatic peroxynitrite (ONOO-) in situ after acetaminophen (APAP) overdose has been developed. Our study provided direct evidence for supporting the generation of ONOO- in APAP-induced liver injury. This new probe will be a useful tool for studying the roles of ONOO-in vivo.
A water-soluble esipt fluorescent probe with high quantum yield and red emission for ratiometric detection of inorganic and organic palladium
Gao, Tang,Xu, Pengfei,Liu, Meihui,Bi, Anyao,Zeng, Wenbin,Hu, Pengzhi,Ye, Bin,Wang, Wei
, p. 1142 - 1145 (2015)
A novel fluorescent probe with a high quantum yield (0.41), large Stokes shifts (255 nm), and red emission (635 nm) was designed to detect all typical oxidation states of palladium species (0, +2, +4) by palladium-mediated terminal propargyl ethers cleavage reaction in water solution without any organic media. The probe showed a high selectivity and excellent sensitivity for palladium species, with a detection as low as 57 nM (6.2 μgL-1).
Fluorometric determination of Au3+ via hydrolysis of thiocarbonate with bromide as a masking agent
Park, So Young,Choi, Myung Gil,Lim, Dae Sung,Chang, Suk-Kyu
, p. 14 - 19 (2019)
Gold ions are very important in chemistry and materials science owing to their various uses in chemical reactions as well as industrial and biological applications. In this study, we developed a novel reaction-based probe (GP), which is a thiocarbonate derivative of the 2-(2-hydroxyphenyl)benzothiazole dye, for the selective and sensitive determination of Au3+. The probe GP showed turn-on fluorescence signaling behavior toward Au3+ ions triggered by the metal-induced hydrolysis of the thiocarbonate group. Interference from other thiophilic ions, Ag+ and Hg2+, was effectively eliminated by using bromide ions as a masking agent. Prominent off–on type fluorescent sensing of Au3+ over other coexisting metal ions was possible with a detection limit of 4.8 × 10?8 M (9.5 ppb). Fluorescence sensing of Au3+ by GP was fast and applicable over a wide pH range between 4.0 and 10.5. Application of the probe to the analysis of Au3+ in synthetic wastewater was conducted using an easily accessible smartphone.
A "turn-On" fluorescent probe for sensitive and selective detection of fluoride ions based on aggregation-induced emission
Du, Man,Huo, Baolong,Li, Mengwen,Shen, Ao,Bai, Xue,Lai, Yaru,Liu, Jiemin,Yang, Yunxu
, p. 32497 - 32505 (2018)
Based on the fluorophore of 2-(2′-hydroxyphenyl)benzothiazole (HBT) with aggregation-induced emission (AIE) properties, a highly selective and sensitive fluorescent probe PBT towards F- was investigated. "Turn-On" fluorescence type signaling was realized by employing fluoride-selective cleavage of the latent thiophosphinated probe in mixed aqueous media. The probe is designed in such a way that the excited state intramolecular proton transfer (ESIPT) of the HBT moiety becomes blocked. The chemodosimetric approach of F- to the probe results in the recovery of the ESIPT by removal of a free AIE-active HBT moiety through a subsequent hydrolysis process. The F- detection limit of the probe was 3.8 nM in the dynamic range of 0.5 μM to 10 μM. In addition, the proposed probe has been used to detect F- in water samples and toothpaste samples with satisfying results.
Mn(I)-based photoCORMs for trackable, visible light-induced CO release and photocytotoxicity to cancer cells
Musib, Dulal,Raza, Md Kausar,Martina, Kh.,Roy, Mithun
, p. 125 - 131 (2019)
Four new Mn(I)–carbonyl complexes of general formula, [Mn(L)(CO)3] (1–4) where L = 2-(benzo[d]thiazol-2-yl)phenol (L1), 2-(benzo[d]thiazol-2-yl)-4,6-di-tert-butylphenol (L2), 2-(2-hydroxyphenyl)-3H-anthra[1,2-d]imidazole-6
Simpler molecular structure as selective & sensitive ESIPT-based fluorescent probe for cysteine and Homocysteine detection with DFT studies
Kaushik, Rahul,Nehra, Nidhi,Tittal, Ram Kumar,Vikas D, Ghule
, (2020)
The undesired research results of triazole synthesis were successfully utilized as a simpler, sensitive and selective turn-on fluorescent probe 2 namely chloro-acetic acid 2-benzothiazol-2-yl-phenyl ester (HBT-AcCl) which was synthesized by simple chloroacylation of 2-hydroxyphenyl benzothiazole (HBT). Only one simple chloroacetate, a trigger unit as the reaction site of probe 2 makes it more simple, sensitive and selective for Cys and Hcy over other Amino Acids. The presented probe HBT-AcCl conserves simple structure, reduces the use of extra chloroacetate and improves %atom economy as compare to similar reported probes. Paper strip tests were carried out to explore the potential application for naked-eye detection of Cys under UV lamp. The selectivity of the HBT-AcCl probe for Cys and Hcy is supported by the results of absorbance and emission spectroscopy experiments and theoretical DFT calculations.
Green synthesis of a benzothiazole based 'turn-on' type fluorimetric probe and its use for the selective detection of thiophenols in environmental samples and living cells
Khandare, Dipratn G.,Banerjee, Mainak,Gupta, Rishabh,Kumar, Nupur,Ganguly, Anasuya,Singh, Deepak,Chatterjee, Amrita
, p. 52790 - 52797 (2016)
We have developed an efficient turn-on type fluorescent chemodosimeter for the detection of aromatic thiols in aqueous media. The probe was successfully synthesized by condensation of 2-aminothiophenol with salicylaldehyde followed by SNAr with
A Schiff base probe for competitively sensing Cu2+ and cysteine through hydrolysis, complexation, and cyclization
Chen, Li,Chen, Liang,Jiang, Yingxia,Ma, Tengchuang,Sun, Xiaodong,Yan, Fanyong,Zhang, Yan
, (2021)
The form of a single response to a single target analyte limits the development of fluorescent probes. Here, a probe (HBTA) based on HBT (2-(2-Hydroxyphenyl)-benzothiazole) was synthesized to achieve a concept about nested probe, completing continuous det
Ruthenium silicate (RS-1) zeolite: novel heterogeneous efficient catalyst for synthesis of 2-arylbenzothiazole derivatives
Gadekar, Sachin P.,Lande, Machhindra K.
, p. 1253 - 1267 (2021/01/06)
Abstract: Mesoporous silicate and transition metal (Ru+3) containing mesoporous silicate materials or ruthenium silicate Ru+3/Si+4 where synthesis by using hydrothermal process. Mesoporous ruthenium silicate (RS-1) and zeo
Pentafluorophenylammonium Triflate: A Mild, Efficient and Reusable Catalyst for the Synthesis of 2-Arylbenzothiazole and 2-Arylbenzothiazoline Derivatives in a Green Chemical Approach
Datta, Arup
, p. 95 - 102 (2021/03/29)
In this work, one pot, simple and environmentally benign effective synthesis of 2-substituted benzothiazole and benzothiazoline derivatives are described in presence of PFPAT (pentafluorophenylammonium triflate) catalyst in water successfully. A series of benzothiazole derivative were synthesized by the reaction between 2-aminothiophenol and various aldehydes in good yields. Recyclability of the catalyst is observed for four times without loss of its activity in aqueous medium.